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    Drive system with a multiturn rotary stop
    1.
    发明授权
    Drive system with a multiturn rotary stop 失效
    带多圈旋转停止的驱动系统

    公开(公告)号：US5479929A

    公开(公告)日：1996-01-02

    申请号：US267594

    申请日：1994-06-27

    申请人： Thomas G. Cooper ,  David V. Adams ,  John W. Eaton

    发明人： Thomas G. Cooper ,  David V. Adams ,  John W. Eaton

    IPC分类号： A61B8/12 ,  A61B8/00

    CPC分类号： A61B8/12 ,  A61B8/445 ,  A61B8/4461

    摘要： A drive system with a rotary stop for driving a rotatable load is provided having a motor, a rotary stop and a spring stop assembly for coupling the motor to the rotary stop. The spring stop assembly has a motor-driven gear coupled to a hub by a torsional spring. A position encoder may be attached to the motor. In addition, a drive shaft may be coupled to the motor and the multiturn rotary stop through the spring stop assembly.

    摘要翻译： 提供具有用于驱动可旋转负载的旋转止动件的驱动系统，其具有电动机，旋转止动器和用于将电动机联接到旋转止动件的弹簧止动组件。 弹簧止动组件具有通过扭转弹簧联接到轮毂的电机驱动齿轮。 位置编码器可以附接到电动机。 此外，驱动轴可以通过弹簧止动组件联接到马达和多圈旋转止动件。

    Ultrasonic transducer probe with axisymmetric lens
    2.
    发明授权
    Ultrasonic transducer probe with axisymmetric lens 失效
    超声波换能器探头带有轴对称镜头

    公开(公告)号：US5626138A

    公开(公告)日：1997-05-06

    申请号：US482922

    申请日：1995-06-07

    申请人： John A. Hossack ,  John W. Eaton ,  Thomas G. Cooper

    发明人： John A. Hossack ,  John W. Eaton ,  Thomas G. Cooper

    IPC分类号： A61B8/12 ,  G10K11/00 ,  G10K11/02 ,  G10K11/30 ,  H04R1/34

    CPC分类号： A61B8/12 ,  A61B8/445 ,  A61B8/4461 ,  G10K11/004 ,  G10K11/02 ,  G10K11/30

    摘要： According to the present invention, an ultrasonic transducer probe is provided having an array of ultrasonic transducers rotatably mounted about an axis within the ultrasonic transducer probe, a lens mounted to the array, and a housing encasing the array and the lens. The lens is symmetric about the axis of rotation of the array. In addition, the housing has a continuous upper surface that is formed, in a region adjacent to the symmetric lens, to mate with the symmetric lens.

    摘要翻译： 根据本发明，提供一种超声波换能器探头，其具有围绕超声波换能器探针中的轴线可旋转地安装的超声波换能器阵列，安装到阵列的透镜以及包围阵列和透镜的壳体。 透镜相对于阵列的旋转轴线是对称的。 此外，壳体具有在与对称透镜相邻的区域中形成的连续上表面，以与对称透镜配合。

    Flexible ultrasonic transducers and related systems
    4.
    发明授权
    Flexible ultrasonic transducers and related systems 失效
    灵活的超声换能器及相关系统

    公开(公告)号：US5680863A

    公开(公告)日：1997-10-28

    申请号：US657646

    申请日：1996-05-30

    申请人： John A. Hossack ,  John W. Eaton ,  Thomas G. Cooper ,  Michael H. Ikeda ,  David J. Rosa

    发明人： John A. Hossack ,  John W. Eaton ,  Thomas G. Cooper ,  Michael H. Ikeda ,  David J. Rosa

    IPC分类号： A61B8/00 ,  A61B8/12 ,  G01S15/89 ,  G10K11/32 ,  G10K11/34

    CPC分类号： A61B8/4281 ,  A61B8/12 ,  G10K11/32 ,  G10K11/341 ,  A61B8/445 ,  G01S15/892

    摘要： A phased array transducer for an ultrasonic imaging system includes a flexible support element which supports an array of piezoelectric transducer elements. Shape transducers such as strain gauges or capacitive transducers are coupled to the support element to generate a signal indicative of the instantaneously prevailing curvature of the array. A user-controlled actuator is coupled to the support element to flex the support element between at least first and second configurations, wherein the support element has separate curvatures along the axis of the transducer in each of the first and second configurations. In some applications the transducer elements are positioned for separate scan formats in the first and second configurations. The support element can be provided with first and second alternating regions which differ in flexibility, in order to concentrate flexing of the support element in the second regions. In some applications the support element may have a cross-sectional dimension of less than about ten millimeters to facilitate insertion of the transducer into a tortuous vessel of a living subject.

    摘要翻译： 用于超声成像系统的相控阵转换器包括支撑压电换能器元件阵列的柔性支撑元件。 诸如应变仪或电容式换能器的形状换能器耦合到支撑元件以产生指示阵列瞬时占据的曲率的信号。 用户控制的致动器联接到支撑元件以在至少第一和第二配置之间弯曲支撑元件，其中支撑元件在第一和第二构造中的每一个中沿着换能器的轴线具有单独的曲率。 在一些应用中，换能器元件被定位成在第一和第二配置中分开的扫描格式。 支撑元件可以设置有不同柔性的第一和第二交替区域，以便集中在第二区域中的支撑元件的弯曲。 在一些应用中，支撑元件可以具有小于约十毫米的横截面尺寸，以便于将换能器插入活体的曲折血管。

    Ultrasonic transducer assembly controller
    5.
    发明授权
    Ultrasonic transducer assembly controller 有权
    超声波换能器组装控制器

    公开(公告)号：US06464645B1

    公开(公告)日：2002-10-15

    申请号：US09434594

    申请日：1999-11-05

    申请人： William J. Park ,  Douglas B. Dull ,  John W. Eaton ,  Robert A Howard ,  Stephen L. Ijams

    发明人： William J. Park ,  Douglas B. Dull ,  John W. Eaton ,  Robert A Howard ,  Stephen L. Ijams

    IPC分类号： A61B812

    CPC分类号： A61M25/0147 ,  A61B1/0052 ,  A61B8/12 ,  A61B8/4466 ,  A61B8/4488 ,  A61B2018/00916 ,  A61M25/0136

    摘要： A controller for an ultrasonic transducer assembly includes a housing having a longitudinal axis that extends generally parallel to the proximal end of a conduit, such as a catheter. A steering actuator is mounted to the housing for rotation about the longitudinal axis, and a steering hub is mounted for rotation in the housing and coupled to the steering actuator such that rotation of the steering ring with respect to the housing causes rotation of the steering hub. A steering line is secured adjacent the steering hub and extends to the distal end of the conduit such that rotation of the steering hub alters the effective length of the steering line to steer the distal end. The steering line is wrapped at least partially around a stator to avoid threading the steering line through multiple holes and slots prior to termination to the steering hub. The steering line is preferably formed of a liquid crystal polymer, and the housing of the steering mechanism preferably contains an extension portion to ensure that the portion of the housing that the user grips to manipulate the steering mechanism is sufficiently far away from the cable to ensure that the cable will remain sterile and thus reusable. In an additional preferred embodiment, the controller is contoured to a human hand to provide a comfortable, efficient, and enjoyable one-handed operation.

    摘要翻译： 用于超声换能器组件的控制器包括壳体，该壳体具有大致平行于诸如导管的导管的近端延伸的纵向轴线。 转向致动器安装到壳体上以围绕纵向轴线旋转，并且转向轮毂安装成用于在壳体中旋转并联接到转向致动器，使得转向环相对于壳体的旋转引起转向轮毂的旋转 。 转向线固定在转向轮毂附近并且延伸到导管的远端，使得转向轮毂的旋转改变转向线的有效长度以转向远端。 转向线至少部分地围绕定子包裹，以避免在终止到转向轮毂之前将转向线穿过多个孔和槽。 转向线优选地由液晶聚合物形成，并且转向机构的壳体优选地包含延伸部分，以确保用户抓住操纵转向机构的壳体部分足够远离电缆以确保 电缆将保持无菌并因此可重复使用。 在另外的优选实施例中，控制器被轮廓化为人的手，以提供舒适，有效和愉快的单手操作。

    Method for manufacturing an end portion surrounding a catheter-mounted phased-array ultrasound transducer
    6.
    发明授权
    Method for manufacturing an end portion surrounding a catheter-mounted phased-array ultrasound transducer 有权
    用于制造围绕导管安装的相控阵超声换能器的端部的方法

    公开(公告)号：US6149599A

    公开(公告)日：2000-11-21

    申请号：US206680

    申请日：1998-12-07

    申请人： Randall L. Schlesinger ,  Michael G. Curley ,  John W. Eaton

    发明人： Randall L. Schlesinger ,  Michael G. Curley ,  John W. Eaton

    IPC分类号： A61B1/005 ,  A61B8/12 ,  A61M25/01 ,  A61B8/00

    CPC分类号： A61B8/12 ,  A61B1/0052 ,  A61B8/4488 ,  A61M25/0133 ,  A61M25/0136 ,  A61B2018/00916 ,  A61B8/445

    摘要： The preferred embodiments include a method for manufacturing an end portion surrounding a catheter-mounted phased-array ultrasound transducer. The material used for the end portion can be altered to give the end portion focusing, defocusing, or non-focusing characteristics. In one preferred embodiment, a thermoplastic material is injection molded or insert molded around a phased-array ultrasound transducer carried at a distal end of a catheter. In another preferred embodiment, a thermoset material is used to form the end portion using a casting or transfer molding technique. In yet another preferred embodiment, the phased-array ultrasound transducer is placed into a pre-formed end portion. The pre-formed end portion can be adhesively-attached to the phased-array transducer and catheter. If the pre-formed end portion is made from a thermoplastic material, the end portion can be thermally melted to attach the end portion to the phased-array transducer and catheter.

    摘要翻译： 优选实施例包括用于制造围绕导管安装的相控阵超声换能器的端部的方法。 用于端部的材料可以改变以给出端部聚焦，散焦或非聚焦特性。 在一个优选实施例中，将热塑性材料注射模制或插入模制在围绕导管远端承载的相控阵超声换能器周围。 在另一个优选实施例中，使用热固性材料来使用铸造或传递模塑技术形成端部。 在另一优选实施例中，将相控阵超声波换能器放置在预先形成的端部。 预成形的端部可以粘附到相控阵换能器和导管上。 如果预先形成的端部由热塑性材料制成，则端部可以被热熔化以将端部附接到相控阵换能器和导管。

    Biocompatible materials comprising albumin-binding dyes
    8.
    发明授权
    Biocompatible materials comprising albumin-binding dyes 失效
    包含ALBUMIN-BINDING DYES的生物成分材料

    公开(公告)号：US5073171A

    公开(公告)日：1991-12-17

    申请号：US296496

    申请日：1989-01-12

    申请人： John W. Eaton

    发明人： John W. Eaton

    IPC分类号： A61L33/12

    CPC分类号： A61L33/128 ,  Y10S623/92 ,  Y10S623/921

    摘要： A biocompatible prosthetic device is provided which comprises a solid polymeric body incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a physiological fluid containing albumin. A method of increasing the albumin-binding ability of a prosthetic device is also provided.

    摘要翻译： 提供了一种生物相容性假体装置，其包括固体聚合物体，当该装置与含有白蛋白的生理液体接触时，该固体聚合物体结合了一定量的能够在所述装置上形成内源白蛋白涂层的白蛋白结合染料。 还提供了增加假体装置的白蛋白结合能力的方法。

    Method for the early diagnosis of bordetella diseases and kit therefor
    9.
    发明授权
    Method for the early diagnosis of bordetella diseases and kit therefor 失效
    波尔多氏病早期诊断方法及其试剂盒

    公开(公告)号：US4652521A

    公开(公告)日：1987-03-24

    申请号：US707806

    申请日：1985-03-04

    申请人： Dennis L. Confer ,  John W. Eaton

    发明人： Dennis L. Confer ,  John W. Eaton

    IPC分类号： G01N33/50 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/04 ,  C12Q1/16 ,  C12Q1/527 ,  G01N33/566 ,  C12M1/24 ,  C12M1/30 ,  C12M1/40 ,  C12Q1/06

    CPC分类号： G01N33/566 ,  C12Q1/04 ,  C12Q1/527 ,  G01N2333/235 ,  Y10S435/803 ,  Y10S436/81

    摘要： A method for the early diagnosis of Bordetella diseases based on the detection of Bordetella adenylate cyclase and the ability of this enzyme to catalyze the formation of cyclic adenosine monophosphate (cAMP). A sample secretion is taken from a suspected victim of a Bordetella disease (the most common of which in humans is whooping cough) and incubated under conditions to promote the formation of cAMP, which may then be measured as evidence of the presence of the disease. A sample of nasopharyngeal secretions is maintained in a nutrient medium pending assay. An adenylate cyclase assay is made by incubating the sample with adenosine triphosphate (ATP) and the calcium binding protein calmodulin to generate cAMP. The cAMP is measured by any of several known available methods. To facilitate diagnosis, a kit is provided containing the materials necessary for collection of secretion specimens, for storage of specimens pending assay, and transport of specimens to the assay laboratory, and for performing the assay and determining the result.

    摘要翻译： 一种基于伯氏杆菌腺苷酸环化酶的检测和该酶催化环磷酸腺苷（cAMP）形成的能力，早期诊断博德氏病的方法。 样品分泌物是从疑似Bordetella病患者（其中最常见的是百日咳）中取出，并在促进cAMP形成的条件下培养，然后可以将其作为该疾病存在的证据进行测量。 将待分析的鼻咽分泌物样品保持在营养培养基中。 通过将样品与三磷酸腺苷（ATP）和钙结合蛋白钙调素一起孵育以产生cAMP来制备腺苷酸环化酶测定。 cAMP通过几种已知的可用方法中的任何一种来测量。 为了便于诊断，提供了一个试剂盒，其中包含收集分泌标本所需的材料，用于储存待测试的样品，并将样品运送到测定实验室，以及进行测定和确定结果。

    Method and agents for raising animal tolerance to oxidant stress-inducing antibiotics
    10.
    发明授权
    Method and agents for raising animal tolerance to oxidant stress-inducing antibiotics 失效
    提高动物对氧化应激诱导抗生素的耐受性的方法和试剂

    公开(公告)号：US4548927A

    公开(公告)日：1985-10-22

    申请号：US497786

    申请日：1983-05-25

    申请人： John W. Eaton

    发明人： John W. Eaton

    IPC分类号： C07D279/18 ,  A61K31/54 ,  A61K31/70 ,  C07H15/252 ,  C07H15/26 ,  A61K31/71

    CPC分类号： C07H15/26 ,  A61K31/54 ,  A61K31/70 ,  C07H15/252

    摘要： A method and agents are disclosed for raising the tolerance of animal tissue to antibiotic compounds that induce oxidant stress. The method comprises administering one or more nontoxic redox compounds to the locus of administration of the antibiotic in an amount sufficient to diminish the production of the potentially toxic oxidants. The redox compounds may be administered by various parenteral techniques. The agents comprise redox compounds and include redox dyes such as those of the thiazine group. Of this group methylene blue is preferred. A method for treating cancer in animals is also disclosed.

    摘要翻译： 公开了用于提高动物组织对诱导氧化应激的抗生素化合物的耐受性的方法和试剂。 该方法包括将一种或多种无毒的氧化还原化合物施用至足以减少潜在有毒氧化剂产生量的抗生素施用场所。 氧化还原化合物可以通过各种肠胃外技术施用。 这些试剂包括氧化还原化合物，并且包括氧化还原染料，例如噻嗪基的那些。 在该组中，优选亚甲基蓝。 还公开了一种治疗动物癌症的方法。