公开(公告)号：US06350890B1

公开(公告)日：2002-02-26

申请号：US09744142

申请日：2001-02-16

申请人： Thomas Kiy ,  Christoph Siffrin ,  Heinz Engelhardt ,  Dirk Fabritius

发明人： Thomas Kiy ,  Christoph Siffrin ,  Heinz Engelhardt ,  Dirk Fabritius

IPC分类号： C11C100

CPC分类号： C11C3/003 ,  A23L33/12 ,  A61K31/23 ,  B01D15/08 ,  C11B1/104 ,  C11B7/005 ,  C11C3/10

摘要： The invention relates to a method for obtaining fatty acid esters and fatty acids, preferably unsaturated fatty acid ethyl esters, from biological sources by continuous, combined in-situ extraction, reaction and chromatography. The invention is characterized in that simultaneously and in the same location, in the presence of a compressed gas and an 0.5-5 % stream of lower alcohols as modifiers and in the presence of an inert catalyst, the fatty acids are fully transesterified from their native fatty acid sources, which are selectively desorbed and eluated in the conditions specified above.

摘要翻译： 本发明涉及一种通过连续的原位萃取，反应和层析法从生物来源获得脂肪酸酯和脂肪酸，优选不饱和脂肪酸乙酯的方法。 本发明的特征在于，在压缩气体和0.5-5％的低级醇流作为改性剂的同时和在相同的位置，在惰性催化剂的存在下，脂肪酸从它们的天然物完全酯交换 脂肪酸源，其在上述条件下被选择性地解吸和洗脱。

公开(公告)号：US5888366A

公开(公告)日：1999-03-30

申请号：US914124

申请日：1997-08-19

申请人： Heinz Engelhardt ,  Thomas Schmitt ,  Konstantin Shoiket

发明人： Heinz Engelhardt ,  Thomas Schmitt ,  Konstantin Shoiket

IPC分类号： G01N27/447 ,  C25B7/00 ,  C25B9/00 ,  C25B15/00 ,  C25D1/12

CPC分类号： G01N27/44704

摘要： A capillary made of plastics material that is suited for use in capillary electrophoresis. The capillary has its inner surface chemically modified for the generation of properties different from those of the original plastic capillary material. In the process of producing such capillaries, a premanufactured capillary is treated with a chemical reagent which generates functional groups directly on the capillary surface or generates attachment sites, on the capillary surface to which functional groups are later bonded.

摘要翻译： 由塑料材料制成的毛细管，适用于毛细管电泳。 毛细管的内表面被化学改性，用于产生与原始塑料毛细管材料不同的性能。 在制造这样的毛细管的过程中，使用化学试剂处理预制毛细管，所述化学试剂在毛细管表面上直接产生功能基团，或者在随后结合官能团的毛细管表面上产生附着位点。

公开(公告)号：US5362895A

公开(公告)日：1994-11-08

申请号：US25041

申请日：1993-03-01

申请人： Heinz Engelhardt ,  Rudolf Krumbholz ,  Peter Lembke

发明人： Heinz Engelhardt ,  Rudolf Krumbholz ,  Peter Lembke

IPC分类号： C07C69/587 ,  B01D15/08 ,  C07C51/47 ,  C07C57/03 ,  C07C57/12 ,  C07C67/56 ,  C11B3/10 ,  C11C1/00 ,  C11C1/08

CPC分类号： C11C1/005 ,  B01D15/40 ,  C07C51/47 ,  C07C67/56 ,  Y02P20/544

摘要： A method for recovering at least one unsaturated fatty acid having sixteen or more carbon atoms and/or at least one compound of such a fatty acid from a mixture derived from vegetable, animal or marine sources is provided. Fatty acids and/or fatty acid compounds of the mixture, in free acid or esterified form, are passed into a mobile phase of liquid carbon dioxide in a column over a stationary phase. The stationary phase contains a support and a material bound to the support which contains at least one free electron pair and/or multiple bond. After eluting any saturated fatty acid or fatty acid compound of the same number of carbon atoms from the column, the unsaturated fatty acid and/or fatty acid compound is recovered in pure chemical form or as an enriched mixture.

摘要翻译： 提供了一种从植物，动物或海洋来源的混合物中回收至少一种具有十六个或更多个碳原子的不饱和脂肪酸和/或至少一种这样的脂肪酸化合物的方法。 混合物中的游离酸或酯化形式的脂肪酸和/或脂肪酸化合物在固定相中通入柱中液体二氧化碳的流动相。 固定相包含载体和与载体结合的材料，其含有至少一个自由电子对和/或多个键。 在从柱中洗脱相同数目的碳原子的饱和脂肪酸或脂肪酸化合物后，以纯化学形式或富集的混合物回收不饱和脂肪酸和/或脂肪酸化合物。

公开(公告)号：US5750679A

公开(公告)日：1998-05-12

申请号：US294803

申请日：1994-08-25

申请人： Peter Haas ,  Heinz Engelhardt ,  Stefan Mullner

发明人： Peter Haas ,  Heinz Engelhardt ,  Stefan Mullner

IPC分类号： A61K45/00 ,  B01D11/00 ,  B01D11/02 ,  C07B63/02 ,  C07C29/88 ,  C07C51/48 ,  C07C67/58 ,  G01N30/06 ,  C07H1/00 ,  B01D11/04 ,  C07C27/10 ,  C07D305/00

CPC分类号： C07C51/48 ,  C07B63/02 ,  C12C11/02 ,  Y02P20/544

摘要： A process for obtaining pharmacologically active compounds from complex mixtures of substances Free organic acids, hydroxy acids, fatty alcohols, sugars and hydroxy-substituted steroids are obtained from complex mixtures of substances by mixing the material to be extracted with a polar solvent, drying the resulting mixture, subsequently silylating, esterifying or acylating, and extracting the resulting material with a supercritical fluid under a pressure of more than 200 bar.

摘要翻译： 从物质的复杂混合物获得药理活性化合物的方法游离有机酸，羟基酸，脂肪醇，糖和羟基取代的类固醇通过将待萃取的材料与极性溶剂混合，从物质的复杂混合物中获得，干燥所得 混合物，随后进行甲硅烷基化，酯化或酰化，并在超过200巴的压力下用超临界流体萃取所得材料。