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公开(公告)号：US20120225882A1
公开(公告)日：2012-09-06
申请号：US13469427
申请日：2012-05-11
IPC分类号： C07C311/37 , A61P11/00 , A61P19/02 , A61P9/10 , A61P35/00 , A61P1/16 , A61P13/12 , A61P29/00 , A61P9/04 , A61P25/00 , A61K31/4453 , A61K31/5375 , A61K31/495 , A61K31/4462 , A61P35/04 , A61P11/06
CPC分类号： C07C311/19 , C07B2200/09 , C07C311/29 , C07C311/42 , C07C311/46 , C07C311/47 , C07D213/42 , C07D295/13
摘要： The present invention provides a compound of formula (I): said compound is inhibitor of MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-9, and/or MMP-12 and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译： 本发明提供式（I）化合物：所述化合物是MMP-9和/或MMP-12和/或MMP-13的抑制剂，因此可用于治疗以异常为特征的病症或疾病 MMP-9和/或MMP-12和/或MMP-13的活性。 因此，式（I）化合物可用于治疗由MMP-9和/或MMP-12和/或MMP-13介导的疾病或疾病。 最后，本发明还提供药物组合物。
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公开(公告)号：US20090318511A1
公开(公告)日：2009-12-24
申请号：US12295170
申请日：2007-03-27
IPC分类号： A61K31/44 , C07C311/15 , C07D213/56 , A61K31/18 , A61P35/00
CPC分类号： C07C311/19 , C07B2200/09 , C07C311/29 , C07C311/42 , C07C311/46 , C07C311/47 , C07D213/42 , C07D295/13
摘要： The present invention provides a compound of formula (I): said compound is inhibitor of MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-9, and/or MMP-12 and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译： 本发明提供式（I）化合物：所述化合物是MMP-9和/或MMP-12和/或MMP-13的抑制剂，因此可用于治疗以异常为特征的病症或疾病 MMP-9和/或MMP-12和/或MMP-13的活性。 因此，式（I）化合物可用于治疗由MMP-9和/或MMP-12和/或MMP-13介导的疾病或疾病。 最后，本发明还提供药物组合物。
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公开(公告)号：US08314148B2
公开(公告)日：2012-11-20
申请号：US13469427
申请日：2012-05-11
IPC分类号： A01N41/06 , C07C303/00 , C07D211/70
CPC分类号： C07C311/19 , C07B2200/09 , C07C311/29 , C07C311/42 , C07C311/46 , C07C311/47 , C07D213/42 , C07D295/13
摘要： The present invention provides a compound of formula (I): said compound is inhibitor of MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-9, and/or MMP-12 and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译： 本发明提供式（I）化合物：所述化合物是MMP-9和/或MMP-12和/或MMP-13的抑制剂，因此可用于治疗以异常为特征的病症或疾病 MMP-9，和/或MMP-12和/或MMP-13的活性。 因此，式（I）化合物可用于治疗由MMP-9和/或MMP-12和/或MMP-13介导的疾病或疾病。 最后，本发明还提供药物组合物。
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公开(公告)号：US20080255149A1
公开(公告)日：2008-10-16
申请号：US12088367
申请日：2006-09-25
申请人： Markus Rolf Dobler , Jonathan E. Grob , Arup Patnaik , Branko Radetich , Micheal Shultz , Yanyi Zhu
发明人： Markus Rolf Dobler , Jonathan E. Grob , Arup Patnaik , Branko Radetich , Micheal Shultz , Yanyi Zhu
IPC分类号： A61K31/4035 , C07D209/44 , C07C271/06 , C07D211/70 , A61K31/435 , A61K31/445 , A61K31/496 , A61P35/02 , A61P17/06 , A61P19/02 , A61P35/00 , A61K31/438 , A61K31/44 , A61K31/235 , C07D211/10 , C07D241/04
CPC分类号： C07D209/44 , C07D211/44 , C07D211/70 , C07D221/20 , C07D295/185 , C07D295/192 , C07D401/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/10
摘要： The invention relates to the use of carboxyamine compounds and salts thereof in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.
摘要翻译： 本发明涉及羧胺化合物及其盐在治疗HDAC依赖性疾病中的用途以及用于制备用于治疗所述疾病的药物制剂。
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公开(公告)号：US09452990B2
公开(公告)日：2016-09-27
申请号：US14408216
申请日：2013-06-19
申请人： Michael Dechantsreiter , Jonathan E. Grob , Aengus Macsweeney , Wolfgang Miltz , Stefan Andreas Randl , Richard Sedrani , Holger Sellner , Finton Sirockin , Eric Valeur
发明人： Michael Dechantsreiter , Jonathan E. Grob , Aengus Macsweeney , Wolfgang Miltz , Stefan Andreas Randl , Richard Sedrani , Holger Sellner , Finton Sirockin , Eric Valeur
IPC分类号： C07D239/95 , C07D403/12 , C07D401/14 , C07D413/14 , C07D401/12 , C07D403/04 , C07D403/14 , C07D405/12 , C07D409/12 , A61K31/517 , A61K31/5377
CPC分类号： C07D239/95 , A61K31/517 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/14
摘要： The present invention provides a compound of formula I a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitor of the complement alternative pathway and particularly as inhibitor of Factor B for the treatment of e.g. age-related macular degeneration and diabetic retinopathy. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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