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    Consumable for laser capture microdissection
    1.
    发明授权
    Consumable for laser capture microdissection 失效
    可用于激光捕获显微切割

    公开(公告)号：US07075640B2

    公开(公告)日：2006-07-11

    申请号：US08984979

    申请日：1997-12-04

    申请人： Thomas M. Baer ,  David F. Head ,  John Toeppen

    发明人： Thomas M. Baer ,  David F. Head ,  John Toeppen

    IPC分类号： G01N21/01

    CPC分类号： G01N1/2813 ,  G01N2001/028 ,  G01N2001/2833 ,  G01N2001/284

    摘要： Systems and methods for acquiring laser capture microdissection samples are disclosed. An integral portion of a biological reaction vessel includes a transfer film carrier having a substrate surface; and a laser capture microdissection transfer film coupled to the substrate surface of the transfer film carrier. The systems and methods facilitate quick and accurate laser capture microdissection while simultaneously minimizing contamination.

    摘要翻译： 公开了用于获取激光捕获显微解剖样品的系统和方法。 生物反应容器的整体部分包括具有基底表面的转移膜载体; 以及耦合到转印膜载体的基板表面的激光捕获显微切割转印膜。 系统和方法有助于快速准确的激光捕获显微切割，同时最大限度地减少污染。

    Consumable for laser capture microdissection
    2.
    发明授权
    Consumable for laser capture microdissection 有权
    可用于激光捕获显微切割

    公开(公告)号：US07221447B2

    公开(公告)日：2007-05-22

    申请号：US11276887

    申请日：2006-03-17

    申请人： Thomas M. Baer ,  David F. Head ,  John Toeppen

    发明人： Thomas M. Baer ,  David F. Head ,  John Toeppen

    IPC分类号： G01N21/01

    CPC分类号： G01N1/2813 ,  G01N2001/028 ,  G01N2001/2833 ,  G01N2001/284

    摘要： Systems and methods for acquiring laser capture microdissection samples are disclosed. A scattering media is located within a beam path defined by the laser capture microdissection microscope and the sample is imaged through the scattering media. A transfer film carrier includes a substrate surface and a laser capture microdissection transfer film coupled to the substrate surface of the transfer film carrier. The scattering media is optically coupled to a laser capture microdissection transfer film being located in or attached to the laser capture microdissection transfer film or transfer film carrier. The systems and methods provide improved sample imaging and facilitate quick and accurate laser capture microdissection while simultaneously minimizing contamination.

    摘要翻译： 公开了用于获取激光捕获显微解剖样品的系统和方法。 散射介质位于由激光捕获显微切割显微镜限定的光束路径内，并且样品通过散射介质成像。 转印膜载体包括与转印膜载体的基板表面耦合的基板表面和激光捕获显微解剖转印膜。 散射介质光学耦合到位于激光捕获显微解剖转移膜或转移膜载体中或附着于激光捕获显微解剖转移膜或转移膜载体的激光捕获显微解剖转移膜。 这些系统和方法提供了改进的样品成像，并促进了快速准确的激光捕获显微解剖，同时最大限度地减少了污染。

    Method of manufacturing consumable for laser capture microdissection
    3.
    发明授权
    Method of manufacturing consumable for laser capture microdissection 失效
    激光捕获显微切割消耗品的制造方法

    公开(公告)号：US5985085A

    公开(公告)日：1999-11-16

    申请号：US984983

    申请日：1997-12-04

    申请人： Thomas M. Baer ,  David F. Head ,  John Toeppen

    发明人： Thomas M. Baer ,  David F. Head ,  John Toeppen

    IPC分类号： G01N1/02 ,  G01N1/28 ,  B32B31/26 ,  C12Q1/00

    CPC分类号： G01N1/2813 ,  G01N2001/028 ,  G01N2001/2833 ,  G01N2001/284 ,  Y10T436/25375

    摘要： Systems and methods for acquiring laser capture microdissection samples are disclosed. A method of making a laser capture microdissection consumable includes providing a transfer film carrier having a substrate surface; and fabricating a laser capture microdissection transfer film on said substrate surface, wherein forming includes hot vacuum baking said laser capture microdissection transfer film. The systems and methods facilitate quick and accurate laser capture microdissection while simultaneously minimizing contamination.

    摘要翻译： 公开了用于获取激光捕获显微解剖样品的系统和方法。 制造激光捕获显微解剖消耗品的方法包括提供具有基底表面的转移膜载体; 以及在所述衬底表面上制造激光捕获显微切割转移膜，其中形成包括热真空烘烤所述激光捕获显微切割转移膜。 系统和方法有助于快速准确的激光捕获显微切割，同时最大限度地减少污染。

    Laser capture microdissection analysis vessel
    6.
    发明授权
    Laser capture microdissection analysis vessel 失效
    激光捕获显微解剖分析容器

    公开(公告)号：US5859699A

    公开(公告)日：1999-01-12

    申请号：US797026

    申请日：1997-02-07

    申请人： Thomas M. Baer ,  David F. Head

    发明人： Thomas M. Baer ,  David F. Head

    IPC分类号： G01N33/48 ,  B01L3/00 ,  B01L3/14 ,  G01N1/00 ,  G01N1/02 ,  G01N1/28 ,  G02B21/34 ,  G01N1/10

    CPC分类号： B01L3/50853 ,  B01L3/50825 ,  G01N1/2813 ,  G02B21/34 ,  B01L2300/021 ,  B01L2300/047 ,  G01N2001/284

    摘要： A laser capture microdissection lift-off substrate comprising a transparent thermoplastic film is incorporated into substrate which may take the form of a cap or other structure associated with an analysis vessel or which may be used with a holder or other element of a LCM tissue sample transfer apparatus. The thermoplastic lift-off substrate film is held in a fixed position on the substrate which may be relative to a feature of a biological analysis vessel. The film may be affixed to a substrate which is a structure which goes into the vessel such that the sample is held in a fixed position relative to an observation port on the vessel.

    摘要翻译： 将包含透明热塑性薄膜的激光捕获显微切割剥离基底结合到基底中，基底可以采取与分析容器相关联的帽或其它结构的形式，或者可以与LCM组织样品转移的保持器或其他元件一起使用 仪器。 热塑性剥离基材膜保持在基板上的固定位置，其可以相对于生物分析容器的特征。 该膜可以固定到基底上，该基底是进入血管的结构，使得样品相对于血管上的观察孔保持在固定位置。

    Dispersion compensated fiber Raman oscillator
    7.
    发明授权
    Dispersion compensated fiber Raman oscillator 失效
    色散补偿光纤拉曼振荡器

    公开(公告)号：US4685107A

    公开(公告)日：1987-08-04

    申请号：US872295

    申请日：1986-06-09

    申请人： James D. Kafka ,  Thomas M. Baer ,  David F. Head

    发明人： James D. Kafka ,  Thomas M. Baer ,  David F. Head

    IPC分类号： H01S3/083 ,  H01S3/108 ,  H01S3/30

    CPC分类号： H01S3/083 ,  H01S3/1086 ,  H01S3/302

    摘要： A dispersion compensation delay line is added to a synchronously pumped fiber Raman ring oscillator to generate subpicosecond pulses. A pair of spaced gratings form the delay line. An interference filter is used as a bandwidth limiting tuning element to provide a good quality short pulse. An integrated design eliminates the discrete optical elements by using only an optical fiber and an optical fiber coupler.

    摘要翻译： 将色散补偿延迟线添加到同步泵浦光纤拉曼环形振荡器以产生亚秒脉冲。 一对隔开的光栅形成延迟线。 干扰滤波器被用作带宽限制调谐元件，以提供良好质量的短脉冲。 集成设计通过仅使用光纤和光纤耦合器消除了分立的光学元件。

    High-efficiency mode-matched transversely-pumped solid state laser amplifier
    9.
    发明授权
    High-efficiency mode-matched transversely-pumped solid state laser amplifier 失效
    高效模式匹配横向泵浦固态激光放大器

    公开(公告)号：US5181223A

    公开(公告)日：1993-01-19

    申请号：US714790

    申请日：1991-06-12

    申请人： Thomas M. Baer ,  David F. Head

    发明人： Thomas M. Baer ,  David F. Head

    IPC分类号： H01S3/02 ,  H01S3/08 ,  H01S3/0941 ,  H01S3/098 ,  H01S3/109 ,  H01S3/23

    CPC分类号： H01S3/08036 ,  H01S3/08095 ,  H01S3/0941 ,  H01S3/109 ,  H01S3/2316 ,  H01S3/02 ,  H01S3/0621 ,  H01S3/0623

    摘要： In a laser amplifier a high efficiency pumping scheme mode matches the TEMOO laser mode volume with a plurality of linearly spaced laser diode pumping sources positioned along a lateral side of a block of laser material. The optical path within the block is configured in a tightly folded zig-zag configuration. Pump radiation from the diode pumping sources is collimated by an optical fiber end the fold angle is selected to mode match the pump radiation to the mode volume.A laser oscillator is followed by one or more cascaded amplifier stages including a block of laser material arranged in a tightly folded zig-zag configuration. Pump radiation from the diode pumping sources is collimated by an optical fiber and the fold angle is selected to mode match the pump radiation to the mode volume.

    摘要翻译： 在激光放大器中，高效泵浦方案模式将TEM00激光模式体积与沿着激光材料块的侧面定位的多个线性间隔激光二极管泵浦源匹配。 块内的光路被配置成紧密折叠的之字形配置。 来自二极管泵浦源的泵浦辐射通过光纤端被准直，折叠角被选择为将泵浦辐射与模式体积匹配。 激光振荡器之后是一个或多个级联放大器级，其包括以紧凑折叠的之字形配置布置的激光材料块。 来自二极管泵浦源的泵浦辐射由光纤校准，并且折叠角度被选择为将泵辐射与模式体积匹配。