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20 条记录 (耗时 0.022 秒)

    7-Substituted methyl cephalosporins derivatives and analogues thereof
    1.
    发明授权
    7-Substituted methyl cephalosporins derivatives and analogues thereof 失效
    7-取代的甲基头孢菌素衍生物及其类似物

    公开(公告)号：US4296111A

    公开(公告)日：1981-10-20

    申请号：US48551

    申请日：1979-06-14

    申请人： Thomas R. Beattie ,  Burton G. Christensen ,  Frank P. Dininno

    发明人： Thomas R. Beattie ,  Burton G. Christensen ,  Frank P. Dininno

    IPC分类号： C07D501/00

    CPC分类号： C07D501/00

    摘要： Disclosed are antibiotic 7-(substituted methyl) cephalosporins, derivatives and nuclear analogues thereof; wherein the methyl substituent is, inter alia, hydroxyl, ketonic oxygen, imino nitrogen, amino or thio. Also disclosed are processes for the preparation of such compounds and their pharmaceutically acceptable salt, ester and amide derivatives; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

    摘要翻译： 公开了抗生素7-（取代的甲基）头孢菌素，其衍生物和核类似物; 其中甲基取代基尤其是羟基，酮氧，亚氨基氮，氨基或硫代。 还公开了制备这些化合物及其药学上可接受的盐，酯和酰胺衍生物的方法; 包含这些化合物的药物组合物; 和治疗方法，包括当指出抗生素效应时施用这些化合物和组合物。

    6-Substituted methyl penicillins, derivatives and analogues thereof
    2.
    发明授权
    6-Substituted methyl penicillins, derivatives and analogues thereof 失效
    6-取代的甲基青霉素，其衍生物和类似物

    公开(公告)号：US4207323A

    公开(公告)日：1980-06-10

    申请号：US901867

    申请日：1978-05-01

    申请人： Thomas R. Beattie ,  Frank P. Dininno ,  Burton G. Christensen

    发明人： Thomas R. Beattie ,  Frank P. Dininno ,  Burton G. Christensen

    IPC分类号： C07D477/14 ,  C07D487/04 ,  C07D499/00 ,  C07D503/00 ,  A61K31/38

    CPC分类号： C07D477/14 ,  C07D487/04 ,  C07D499/00 ,  C07D503/00

    摘要： Disclosed are antibiotic 6-(substituted methyl) penicillins, derivatives and nuclear analogues thereof; wherein the methyl substituent is, inter alia, hydroxyl, ketonic oxygen, imino nitrogen, amino or thio. Also disclosed are processes for the preparation of such compounds and their pharmaceutically acceptable salt, ester and amide derivatives; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

    摘要翻译： 公开了抗生素6-（取代甲基）青霉素，其衍生物和核类似物; 其中甲基取代基尤其是羟基，酮氧，亚氨基氮，氨基或硫代。 还公开了制备这些化合物及其药学上可接受的盐，酯和酰胺衍生物的方法; 包含这些化合物的药物组合物; 和治疗方法，包括当指出抗生素效应时施用这些化合物和组合物。

    7-(Substituted methyl)-3-(substituted thio)-cephalosporins, derivatives and pharmaceutical compositions containing them
    3.
    发明授权
    7-(Substituted methyl)-3-(substituted thio)-cephalosporins, derivatives and pharmaceutical compositions containing them 失效
    7-（取代的甲基）-3-（取代的硫代） - 头孢菌素，含有它们的衍生物和药物组合物

    公开(公告)号：US4150156A

    公开(公告)日：1979-04-17

    申请号：US903455

    申请日：1978-05-08

    申请人： Thomas R. Beattie ,  Lovji D. Cama ,  Burton G. Christensen ,  Frank P. Dininno

    发明人： Thomas R. Beattie ,  Lovji D. Cama ,  Burton G. Christensen ,  Frank P. Dininno

    IPC分类号： C07D501/00 ,  A61K31/545

    CPC分类号： C07D501/00

    摘要： Disclosed are antibiotic 3-(substituted thio)-7-(substituted methyl) cephalosporins, derivatives and analogues thereof; wherein the methyl substituent is, inter alia, hydroxyl, ketonic oxygen, imino nitrogen, amino or mercapto. Also disclosed are processes for the preparation of such compounds and their pharmaceutically acceptable salt, ester and amide derivatives; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

    摘要翻译： 公开了抗生素3-（取代的硫代）-7-（取代的甲基）头孢菌素，其衍生物和类似物; 其中甲基取代基尤其是羟基，酮氧，亚氨基氮，氨基或巯基。 还公开了制备这些化合物及其药学上可接受的盐，酯和酰胺衍生物的方法; 包含这些化合物的药物组合物; 和治疗方法，包括当指出抗生素效应时施用这些化合物和组合物。

    Cephalosporin compounds
    9.
    发明授权
    Cephalosporin compounds 失效
    头孢菌素化合物

    公开(公告)号：US4255423A

    公开(公告)日：1981-03-10

    申请号：US819511

    申请日：1977-07-27

    申请人： Thomas R. Beattie ,  John Hannah ,  David B. R. Johnston

    发明人： Thomas R. Beattie ,  John Hannah ,  David B. R. Johnston

    IPC分类号： C07D501/20

    CPC分类号： C07D501/20 ,  C07D501/57

    摘要： Novel cephalosporin compounds having a substituted or unsubstituted vinyl group at the 3-position are prepared by the reaction of a phosphoranylidene compound with a compound containing a carbonyl group. The novel cephalosporin compounds are active against a range of gram-negative and gram-positive microorganisms and are of value in human and veterinary medicine.

    摘要翻译： 通过亚正膦基化合物与含有羰基的化合物的反应制备了在3位上具有取代或未取代的乙烯基的新型头孢菌素化合物。 新型头孢菌素化合物对一系列革兰氏阴性和革兰氏阳性微生物具有活性，在人类和兽医学方面具有重要价值。

    Aminomacrolides and derivatives having immunosuppressive activity
    10.
    发明授权
    Aminomacrolides and derivatives having immunosuppressive activity 失效
    具有免疫抑制活性的氨基马来酰胆碱和衍生物

    公开(公告)号：US5208228A

    公开(公告)日：1993-05-04

    申请号：US698888

    申请日：1991-05-13

    申请人： Hyun O. Ok ,  Thomas R. Beattie ,  Michael H. Fisher ,  Matthew J. Wyvratt ,  Mark Goulet

    发明人： Hyun O. Ok ,  Thomas R. Beattie ,  Michael H. Fisher ,  Matthew J. Wyvratt ,  Mark Goulet

    IPC分类号： C07H19/01

    CPC分类号： C07H19/01

    摘要： Aminomacrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by incorporation of a nitrogen substituent at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses. Also, these macrolides are useful in the treatment of reversible obstructive airways disease, particularly asthma.

    摘要翻译： 通过在环己基环的C-3“和/或C-4”处引入氮取代基，由合适的前体制备了通式结构式I的氨基马来酰氯：。 这些大环内酯类免疫抑制剂可用于哺乳动物宿主用于治疗自身免疫性疾病，感染性疾病和/或预防外来器官移植排斥反应。 此外，这些大环内酯类免疫抑制剂可用于局部治疗炎性和过度增生性皮肤病以及免疫介导疾病的皮肤表现。 此外，这些大环内酯可用于治疗可逆性阻塞性气道疾病，特别是哮喘。