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公开(公告)号：US5087567A
公开(公告)日：1992-02-11
申请号：US464046
申请日：1990-01-12
申请人： Thomas T. Dabrah , Grace A. Hesler , Sandra J. Hofstead , Kin S. Lam , Jacqueline M. Mattei , Daniel R. Schroeder , Koji Tomita
发明人： Thomas T. Dabrah , Grace A. Hesler , Sandra J. Hofstead , Kin S. Lam , Jacqueline M. Mattei , Daniel R. Schroeder , Koji Tomita
IPC分类号： C12P1/04
CPC分类号： C12P1/04 , Y10S435/825
摘要： An antitumor antibiotic designated BMY-42428 is produced by fermentation of Actinomadura madurae ATCC-53806. The BMY-42428 antibiotic exhibits both antimicrobial and antitumor activities.
摘要翻译： 命名为BMY-42428的抗肿瘤抗生素是通过发炎马鞭草ATCC-53806产生的。 BMY-42428抗生素具有抗菌和抗肿瘤活性。
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公开(公告)号：US4973552A
公开(公告)日：1990-11-27
申请号：US482390
申请日：1990-02-20
CPC分类号： C12R1/55 , C12P17/188 , Y10S435/898
摘要： A fermentation process for preparing staurosporine, a known antibiotic, employing a heretofore unknown micrrorganism is described, said microorganism being classified as a novel strain of Streptomyces hygroscopicus being and herein designated Streptomyces hygroscopicus strain C39280-450-9 (ATCC 53730).
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公开(公告)号：US5270186A
公开(公告)日：1993-12-14
申请号：US776526
申请日：1991-10-10
申请人： Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
发明人： Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
CPC分类号： C07H17/08
摘要： An antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.
摘要翻译： 名称为BMY-42448的抗生素是通过发酵小孢子虫（Necomonospora narashinoensis）菌株C39217-R109-7（ATCC-53791）产生的。 BMY-42448具有体外和体内抗肿瘤活性。
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公开(公告)号：US5082933A
公开(公告)日：1992-01-21
申请号：US463220
申请日：1990-01-10
申请人： Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
发明人： Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： A new antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.
摘要翻译： 一种名为BMY-42448的新型抗生素是通过发酵小孢子虫（Necomonospora narashinoensis）菌株C39217-R109-7（ATCC-53791）产生的。 BMY-42448具有体外和体内抗肿瘤活性。
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公开(公告)号：US5304373A
公开(公告)日：1994-04-19
申请号：US780516
申请日：1991-10-22
IPC分类号： A61K35/74 , A61P35/00 , C07G11/00 , C12N1/20 , C12P1/06 , C12R1/03 , C12R21/04 , C12R1/06 , C12P1/03
CPC分类号： C12P1/06 , C07G17/00 , Y10S435/825
摘要： A certain fermentation product of Actinomadura strain Q473-8 yields, when suitably treated, a novel compound having both antibiotic and antitumor activities.
摘要翻译： 当适当处理时，放线菌素Q473-8的某些发酵产物产生具有抗生素和抗肿瘤活性的新型化合物。
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6.发明授权Antitumor process employing novel fermentate of an Actinomadura strain 失效使用Actinomadura菌株的新型发酵物的抗肿瘤方法
公开(公告)号：US5281417A
公开(公告)日：1994-01-25
申请号：US17223
申请日：1993-02-12
CPC分类号： C12P1/06 , C07G17/00 , Y10S435/825
摘要： A certain fermentation product of Actinomadura strain Q473-8 yields, when suitably treated, a novel compound having both antibiotic and antitumor activities.
摘要翻译： 当适当处理时，放线菌素Q473-8的某些发酵产物产生具有抗生素和抗肿瘤活性的新型化合物。
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公开(公告)号：US5468849A
公开(公告)日：1995-11-21
申请号：US216075
申请日：1994-03-21
IPC分类号： C07H17/00 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61P35/00 , C07H19/044 , C07H19/23 , C12P19/28 , C12P19/44 , C12R1/01 , C12R1/645 , C07G3/00 , C07H11/00 , C07H17/02
CPC分类号： C07H19/044 , C12P19/28
摘要： Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin analogs having advantageous antitumor properties.
摘要翻译： 在产生克雷霉素生产菌株的发酵过程中向培养基中加入某些色氨酸类似物导致产生具有有利抗肿瘤性质的新的雷贝卡霉素类似物。
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公开(公告)号：US5158938A
公开(公告)日：1992-10-27
申请号：US764116
申请日：1991-09-23
IPC分类号： C07H19/044 , C12P19/28
CPC分类号： C12P19/28 , C07H19/044
摘要： Addition of bromine to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of a new rebeccamycin derivative having advantageous antineoplastic properties.
摘要翻译： 在克雷霉素生产菌株的发酵过程中向培养基中加入溴导致产生具有有利抗肿瘤性质的新的雷贝卡霉素衍生物。
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公开(公告)号：US5378463A
公开(公告)日：1995-01-03
申请号：US142559
申请日：1993-10-25
CPC分类号： C12P1/06 , C07G17/00 , Y10S435/825
摘要： A certain fermentation product of Actinomadura strain Q473-8 yield, when suitably treated, a novel compound having both antibiotic and antitumor activities.
摘要翻译： 当适当处理时，放线菌素Q473-8的某些发酵产物产生具有抗生素和抗肿瘤活性的新型化合物。
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公开(公告)号：US06752657B2
公开(公告)日：2004-06-22
申请号：US10266782
申请日：2002-10-08
IPC分类号： G05B644
CPC分类号： G02B6/4416 , G02B6/4293 , H01R4/2404
摘要： A connection system for providing multiple modes of electromagnetic connection to a device. This system includes a ribbon cable with a plurality of multi-mode electromagnetic conductors arranged in a serial array, one alongside the other including a central optical conductor disposed between a pair of electrical conductors. The system also includes a multi-mode electromagnetic connector, that includes a housing, and optical transducers disposed between a pair of electrical terminals that have insulation piercing free ends. A cover that latchingly engages the housing applies pressure to the ribbon cable, forcing the ribbon cable to be pierced by the upper ends of the terminals and pressing the optical conductor into optical communication with said transducers. The electrical conductors carry electrical power comprising alternating current, at a frequency ranging between 10 and 30 kHz.
摘要翻译： 一种用于向设备提供多种电磁连接模式的连接系统。 该系统包括具有布置成串联阵列的多个多模式电磁导体的带状电缆，一个并排的另外包括设置在一对电导体之间的中心光导体。 该系统还包括多模式电磁连接器，其包括壳体和设置在具有绝缘穿透自由端的一对电端子之间的光学换能器。 与壳体闩锁接合的盖子对带状电缆施加压力，迫使带状电缆被端子的上端刺穿，并且将光导体压迫与所述换能器进行光通信。 电导体承载10至30 kHz频率范围内的交流电。
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