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公开(公告)号：US5270186A
公开(公告)日：1993-12-14
申请号：US776526
申请日：1991-10-10
申请人： Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
发明人： Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
CPC分类号： C07H17/08
摘要： An antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.
摘要翻译： 名称为BMY-42448的抗生素是通过发酵小孢子虫（Necomonospora narashinoensis）菌株C39217-R109-7（ATCC-53791）产生的。 BMY-42448具有体外和体内抗肿瘤活性。
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公开(公告)号：US5082933A
公开(公告)日：1992-01-21
申请号：US463220
申请日：1990-01-10
申请人： Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
发明人： Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： A new antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.
摘要翻译： 一种名为BMY-42448的新型抗生素是通过发酵小孢子虫（Necomonospora narashinoensis）菌株C39217-R109-7（ATCC-53791）产生的。 BMY-42448具有体外和体内抗肿瘤活性。
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公开(公告)号：US5087567A
公开(公告)日：1992-02-11
申请号：US464046
申请日：1990-01-12
申请人： Thomas T. Dabrah , Grace A. Hesler , Sandra J. Hofstead , Kin S. Lam , Jacqueline M. Mattei , Daniel R. Schroeder , Koji Tomita
发明人： Thomas T. Dabrah , Grace A. Hesler , Sandra J. Hofstead , Kin S. Lam , Jacqueline M. Mattei , Daniel R. Schroeder , Koji Tomita
IPC分类号： C12P1/04
CPC分类号： C12P1/04 , Y10S435/825
摘要： An antitumor antibiotic designated BMY-42428 is produced by fermentation of Actinomadura madurae ATCC-53806. The BMY-42428 antibiotic exhibits both antimicrobial and antitumor activities.
摘要翻译： 命名为BMY-42428的抗肿瘤抗生素是通过发炎马鞭草ATCC-53806产生的。 BMY-42428抗生素具有抗菌和抗肿瘤活性。
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公开(公告)号：US5643871A
公开(公告)日：1997-07-01
申请号：US156479
申请日：1993-11-23
申请人： Thomas T. Dabrah , James A. Matson , Kin Sing Lam , Donald R. Gustavson , Grace A. Hesler , Ronald L. Berry
发明人： Thomas T. Dabrah , James A. Matson , Kin Sing Lam , Donald R. Gustavson , Grace A. Hesler , Ronald L. Berry
IPC分类号： C12P21/02 , A61K38/00 , A61P35/00 , C07K5/083 , C07K7/06 , C07K14/195 , C07K14/41 , C12P21/04 , C12R1/29 , A61K38/15 , C07K11/02
摘要： The present invention relates to novel antitumor depsipeptides produced by Micromonospora strain 39500, ATCC 55011, and having the structural formula ##STR1## wherein R.sub.1 is 2-methylpropanoyl, and R.sub.2 is 2-methylppropanoyl, propanoyl or acetyl; or R.sub.1 is 3-methylbutanoyl, and R.sub.2 is 2-methylpropanoyl or 3-methylbutanoyl; or R.sub.1 is propanoyl, and R.sub.2 is acetyl or propanoyl.
摘要翻译： 本发明涉及由小单孢菌菌株39500，ATCC 55011生产并具有结构式为罗帕酰基的R2和R2为2-甲基丙酰基，丙酰基或乙酰基的新型抗肿瘤depsipeptides; 或R 1为3-甲基丁酰基，R 2为2-甲基丙酰基或3-甲基丁酰基; 或R1是丙酰基，R2是乙酰基或丙酰基。
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公开(公告)号：US4973552A
公开(公告)日：1990-11-27
申请号：US482390
申请日：1990-02-20
CPC分类号： C12R1/55 , C12P17/188 , Y10S435/898
摘要： A fermentation process for preparing staurosporine, a known antibiotic, employing a heretofore unknown micrrorganism is described, said microorganism being classified as a novel strain of Streptomyces hygroscopicus being and herein designated Streptomyces hygroscopicus strain C39280-450-9 (ATCC 53730).
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公开(公告)号：US5015578A
公开(公告)日：1991-05-14
申请号：US482364
申请日：1990-02-20
IPC分类号： C12P17/18 , A61K31/55 , A61K31/70 , A61P31/04 , A61P35/00 , C07D498/22 , C07H19/04 , C07H19/044 , C12N1/20 , C12R1/465 , C12R1/55
CPC分类号： C07H19/04 , Y10S435/898
摘要： A new antitumor antibiotic designated BMY-41950 is produced by fermentation of Streptomyces staurosporeus ATCC 55006 or Streptomyces hygroscopicus ATCC 53730. The BMY-41950 antibiotic exhibits both antimicrobial and antitumor activities.
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公开(公告)号：US5073633A
公开(公告)日：1991-12-17
申请号：US608773
申请日：1990-11-05
IPC分类号： C07H19/04
CPC分类号： C07H19/04
摘要： An antitumor antibiotic designated BMY-41950 is produced by fermentation of Streptomyces staurosporeus ATCC 55006 or Streptomyces hygroscopicus ATCC 53730. The BMY-41950 antibiotic exhibits both antimicrobial and antitumor activities.
摘要翻译： 名称为BMY-41950的抗肿瘤抗生素通过Stautomyces staurosporeus ATCC 55006或吸水链霉菌ATCC 53730的发酵产生。BMY-41950抗生素具有抗微生物和抗肿瘤活性。
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