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公开(公告)号:US5643871A
公开(公告)日:1997-07-01
申请号:US156479
申请日:1993-11-23
申请人: Thomas T. Dabrah , James A. Matson , Kin Sing Lam , Donald R. Gustavson , Grace A. Hesler , Ronald L. Berry
发明人: Thomas T. Dabrah , James A. Matson , Kin Sing Lam , Donald R. Gustavson , Grace A. Hesler , Ronald L. Berry
IPC分类号: C12P21/02 , A61K38/00 , A61P35/00 , C07K5/083 , C07K7/06 , C07K14/195 , C07K14/41 , C12P21/04 , C12R1/29 , A61K38/15 , C07K11/02
摘要: The present invention relates to novel antitumor depsipeptides produced by Micromonospora strain 39500, ATCC 55011, and having the structural formula ##STR1## wherein R.sub.1 is 2-methylpropanoyl, and R.sub.2 is 2-methylppropanoyl, propanoyl or acetyl; or R.sub.1 is 3-methylbutanoyl, and R.sub.2 is 2-methylpropanoyl or 3-methylbutanoyl; or R.sub.1 is propanoyl, and R.sub.2 is acetyl or propanoyl.
摘要翻译: 本发明涉及由小单孢菌菌株39500,ATCC 55011生产并具有结构式为罗帕酰基的R2和R2为2-甲基丙酰基,丙酰基或乙酰基的新型抗肿瘤depsipeptides; 或R 1为3-甲基丁酰基,R 2为2-甲基丙酰基或3-甲基丁酰基; 或R1是丙酰基,R2是乙酰基或丙酰基。
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公开(公告)号:US5270186A
公开(公告)日:1993-12-14
申请号:US776526
申请日:1991-10-10
申请人: Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
发明人: Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
CPC分类号: C07H17/08
摘要: An antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.
摘要翻译: 名称为BMY-42448的抗生素是通过发酵小孢子虫(Necomonospora narashinoensis)菌株C39217-R109-7(ATCC-53791)产生的。 BMY-42448具有体外和体内抗肿瘤活性。
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公开(公告)号:US5082933A
公开(公告)日:1992-01-21
申请号:US463220
申请日:1990-01-10
申请人: Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
发明人: Daniel R. Schroeder , Kin S. Lam , Grace A. Hesler , Donald R. Gustavson , Koji Tomita , Ronald L. Berry
IPC分类号: C07H17/08
CPC分类号: C07H17/08
摘要: A new antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.
摘要翻译: 一种名为BMY-42448的新型抗生素是通过发酵小孢子虫(Necomonospora narashinoensis)菌株C39217-R109-7(ATCC-53791)产生的。 BMY-42448具有体外和体内抗肿瘤活性。
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公开(公告)号:US4807563A
公开(公告)日:1989-02-28
申请号:US73465
申请日:1987-07-15
CPC分类号: A01K1/0125
摘要: A pet litter box, including a device for locking the box after it has been used and re-closed, is formed from a single foldable blank. When the box is closed or re-closed it has inter-laying first and second halves, each having bottom and sidewall portions. The halves are connected to one another by a joining portion, and joining sidewalls. Each of the sidewalls of the first half carries a tab. The sidewall portions of the second half each define a diagonal crease, and the pair of joining side-wall portions each define a diagonal crease and a pair of vertical creases. When the box is fully open its first, second and joining portions define an open tray. After the system has been used the box can be re-closed and locked. During re-closing the joining sidewall portions and the two sidewalls of the second half all fold inwardly at their creases, thereby forming a pair of slots between the pairs of creases on each side. Then, by inserting the tabs carried by the first half sidewalls into the slots which are formed between the creases, re-closing and locking of the box is completed. The box blank may include a flap for securing the box closed before it is utilized, and a handle, and may also include all items which are necessary for pet toiletry, such as a bag of litter, and a liner sized to fit over the open tray.
摘要翻译: 一种宠物垃圾箱,包括用于在使用和重新关闭之后锁定盒的装置,由单个可折叠坯料形成。 当箱子关闭或重新关闭时,它具有互连的第一和第二半部,每个具有底部和侧壁部分。 一半通过连接部分彼此连接,并且连接侧壁。 前半部分的每个侧壁都带有一个舌片。 第二半部的侧壁部分限定对角折痕,并且该对连接侧壁部分各自限定对角线折痕和一对垂直折痕。 当盒子完全打开时,其第一,第二和连接部分限定打开的托盘。 系统使用完成后,可重新关闭并锁定。 在重新关闭期间,连接侧壁部分和第二半部分的两个侧壁全部在其折痕处向内折叠,从而在每侧上的折痕对之间形成一对槽。 然后,通过将由第一半侧壁承载的突片插入形成在折痕之间的槽中,完成箱的重新闭合和锁定。 盒子坯件可以包括用于在使用盒子之前将盒子固定在其上的挡板以及手柄,并且还可以包括宠物化妆品所需的所有物品,例如垃圾袋,以及尺寸适合于开放 托盘。
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