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1.发明申请METHOD OF EVALUATING THE INTEGRITY OF THE PLASMA MEMBRANE OF CELLS BY DETECTING GLYCANS FOUND ONLY INTRACELLULARLY 审中-公开通过检测仅在细胞内发现的糖蛋白来评估细胞等离子体膜的完整性的方法公开(公告)号：US20110143373A1
公开(公告)日：2011-06-16
申请号：US13054632
申请日：2009-07-16
申请人： Tia Hirvonen , Annika Kotovuori , Virve Pitkanen , Suvi Natunen , Johanna Nystedt , Sari Tiitinen , Leena Valmu , Jari Natunen
发明人： Tia Hirvonen , Annika Kotovuori , Virve Pitkanen , Suvi Natunen , Johanna Nystedt , Sari Tiitinen , Leena Valmu , Jari Natunen
IPC分类号： G01N33/68 , C12N5/071 , C12N5/0775
CPC分类号： G01N33/5308 , G01N33/56966 , G01N2400/12 , G01N2400/38
摘要： The invention describes novel reagents that can be applied for analysis of the quality of human cells. The method evaluates the integrity of the plasma membrane of the cells by detecting novel glyco structures found only intracellularly. The method can be applied, for example, to demonstrate exposure of therapeutic cell preparation to potentially harmful conditions. It can also be used as a quality control tool in methods in which intact cell membrane is essential and it can be applied in separation of damaged cells from non- damaged.
摘要翻译： 本发明描述了可用于分析人细胞质量的新型试剂。 该方法通过检测仅在细胞内发现的新型糖结构来评价细胞质膜的完整性。 该方法可以例如用于证明治疗细胞制剂暴露于潜在有害的条件。 它也可以用作质量控制工具，其中完整的细胞膜是必需的，并且可以应用于损坏的细胞与未损坏的分离。
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2.发明申请NOVEL CARBOHYDRATE PROFILE COMPOSITIONS FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开新型碳水化合物人体细胞组成及其分析及其改良方法公开(公告)号：US20100145032A1
公开(公告)日：2010-06-10
申请号：US12523628
申请日：2008-01-18
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinin , Sari Tiitinen , Ulla Impola , Milla Mikkola , Hanna Salo , Olli Aitio , Leena Valmu , Suvi Natunen , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen , Minna Tiitanen , Tia Hirvonen
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinin , Sari Tiitinen , Ulla Impola , Milla Mikkola , Hanna Salo , Olli Aitio , Leena Valmu , Suvi Natunen , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen , Minna Tiitanen , Tia Hirvonen
IPC分类号： C12Q1/02 , C12N5/074 , C12P21/00 , C07K14/435
CPC分类号： G01N33/5308 , C12N5/0606 , C12N5/0647 , C12N2500/34 , G01N2400/38
摘要： The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
摘要翻译： 本发明描述了干细胞聚糖结构的特异性结合剂的试剂和方法。 此外，本发明涉及筛选针对干细胞表面上的特定聚糖表位的另外的结合试剂。 聚糖结构的优选粘合剂包括蛋白质，例如酶，凝集素和抗体。
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公开(公告)号：US20100292095A1
公开(公告)日：2010-11-18
申请号：US12741987
申请日：2008-11-10
申请人： Marja-Leena Laukkanen , Kristiina Takkinen , Jari Natunen , Tero Satomaa , Jaakko Parkkinen , Leena Valmu , Sari Tiitinen , Suvi Natunen
发明人： Marja-Leena Laukkanen , Kristiina Takkinen , Jari Natunen , Tero Satomaa , Jaakko Parkkinen , Leena Valmu , Sari Tiitinen , Suvi Natunen
CPC分类号： C07K16/3076 , C07K2317/21 , C07K2317/622 , G01N33/56966 , G01N2400/10
摘要： This invention relates to antibody engineering technology. More particularly, the present invention relates to human IgM antibodies and derivatives thereof, which have novel binding specificity with regard to several oligosaccharide sequences and/or xenoantigenic sialic acid residue. The present invention also relates to processes for making and engineering such novel saccharide and/or NeuGc-binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics, enabling qualitative and quantitative determination of xenoantigenic NeuGc in biological and raw material samples, as well as in immunotherapy, enabling blocking of xenoantigenic NeuGc in patients.
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公开(公告)号：US20090148839A1
公开(公告)日：2009-06-11
申请号：US11988418
申请日：2006-07-07
申请人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
发明人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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公开(公告)号：US09382512B2
公开(公告)日：2016-07-05
申请号：US13352269
申请日：2012-01-17
申请人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
发明人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
IPC分类号： C12N5/00 , G01N33/50 , G01N33/569 , C12N5/0775
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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公开(公告)号：US20120190058A1
公开(公告)日：2012-07-26
申请号：US13352269
申请日：2012-01-17
申请人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
发明人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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