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    Insecticidal toxin complex fusion protiens
    1.
    发明授权
    Insecticidal toxin complex fusion protiens 有权
    杀虫毒素复合融合蛋白

    公开(公告)号：US08106159B2

    公开(公告)日：2012-01-31

    申请号：US12581449

    申请日：2009-10-19

    申请人： Timothy D. Hey ,  Thomas Meade ,  Stephanie L. Burton ,  Donald Joseph Merlo ,  Qihua Cai ,  Haley Jo Moon ,  Joel Jay Sheets ,  Aaron Todd Woosley

    发明人： Timothy D. Hey ,  Thomas Meade ,  Stephanie L. Burton ,  Donald Joseph Merlo ,  Qihua Cai ,  Haley Jo Moon ,  Joel Jay Sheets ,  Aaron Todd Woosley

    IPC分类号： C07K14/00 ,  C07K17/00 ,  A01N25/00 ,  A61K38/43

    CPC分类号： C12N15/8286 ,  C07K14/195 ,  C07K14/24 ,  C07K14/32 ,  C07K2319/00 ,  C07K2319/55 ,  C12N15/62 ,  Y02A40/162

    摘要： The subject invention relates to insecticidal toxin complex (“TC”) fusion proteins and to polynucleotides that encode these fusion proteins. In some embodiments, the invention provides a fusion protein comprising a Class A protein, a Class B protein, and a Class C TC protein fused together to form a single protein. In some other embodiments, the invention provides a fusion protein comprising a Class B and a Class C TC proteins fused together. In the latter embodiments, the BC or CB fusion protein can be used to enhance or potentiate the anti-insect activity of a “Toxin A” or Class A protein. The subject invention also includes plants, cells (bacterial and plant cells for example), and seeds that comprise the polynucleotides. The subject invention also includes methods of controlling pests (preferably insects and other plant pests) with fusion proteins of the subject invention.

    摘要翻译： 本发明涉及杀虫毒素复合物（“TC”）融合蛋白和编码这些融合蛋白的多核苷酸。 在一些实施方案中，本发明提供了融合蛋白，其包含一起融合以形成单一蛋白质的A类蛋白质，B类蛋白质和C类TC蛋白质。 在一些其他实施方案中，本发明提供了融合蛋白，其包含融合在一起的B类和C类TC蛋白。 在后一个实施方案中，BC或CB融合蛋白可用于增强或增强“毒素A”或A类蛋白的抗昆虫活性。 本发明还包括植物，细胞（例如细菌和植物细胞）和包含多核苷酸的种子。 本发明还包括用本发明的融合蛋白控制害虫（优选昆虫和其它植物害虫）的方法。

    INSECTICIDAL TOXIN COMPLEX FUSION PROTIENS
    2.
    发明申请
    INSECTICIDAL TOXIN COMPLEX FUSION PROTIENS 有权
    杀虫毒素复合融合蛋白

    公开(公告)号：US20100041610A1

    公开(公告)日：2010-02-18

    申请号：US12581449

    申请日：2009-10-19

    申请人： Timothy Denver Hey ,  Thomas Meade ,  Stephanie Love Burton ,  Donald Joseph Merlo ,  Qihua Cai ,  Haley Jo Moon ,  Joel Jay Sheets ,  Aaron Todd Woosley

    发明人： Timothy Denver Hey ,  Thomas Meade ,  Stephanie Love Burton ,  Donald Joseph Merlo ,  Qihua Cai ,  Haley Jo Moon ,  Joel Jay Sheets ,  Aaron Todd Woosley

    IPC分类号： A61K38/16 ,  C07K14/32 ,  A01H5/00 ,  C12N15/11 ,  C12N1/21 ,  C12N5/04

    CPC分类号： C12N15/8286 ,  C07K14/195 ,  C07K14/24 ,  C07K14/32 ,  C07K2319/00 ,  C07K2319/55 ,  C12N15/62 ,  Y02A40/162

    摘要： The subject invention relates to insecticidal toxin complex (“TC”) fusion proteins and to polynucleotides that encode these fusion proteins. In some embodiments, the invention provides a fusion protein comprising a Class A protein, a Class B protein, and a Class C TC protein fused together to form a single protein. In some other embodiments, the invention provides a fusion protein comprising a Class B and a Class C TC proteins fused together. In the latter embodiments, the BC or CB fusion protein can be used to enhance or potentiate the anti-insect activity of a “Toxin A” or Class A protein. The subject invention also includes plants, cells (bacterial and plant cells for example), and seeds that comprise the polynucleotides. The subject invention also includes methods of controlling pests (preferably insects and other plant pests) with fusion proteins of the subject invention.

    摘要翻译： 本发明涉及杀虫毒素复合物（“TC”）融合蛋白和编码这些融合蛋白的多核苷酸。 在一些实施方案中，本发明提供了融合蛋白，其包含一起融合以形成单一蛋白质的A类蛋白质，B类蛋白质和C类TC蛋白质。 在一些其他实施方案中，本发明提供了融合蛋白，其包含融合在一起的B类和C类TC蛋白。 在后一个实施方案中，BC或CB融合蛋白可用于增强或增强“毒素A”或A类蛋白的抗昆虫活性。 本发明还包括植物，细胞（例如细菌和植物细胞）和包含多核苷酸的种子。 本发明还包括用本发明的融合蛋白控制害虫（优选昆虫和其它植物害虫）的方法。

    Insecticidal toxin complex fusion proteins
    3.
    发明授权
    Insecticidal toxin complex fusion proteins 有权
    杀虫毒素复合融合蛋白

    公开(公告)号：US07605228B2

    公开(公告)日：2009-10-20

    申请号：US11070573

    申请日：2005-03-02

    申请人： Timothy Denver Hey ,  Thomas Meade ,  Stephanie Love Burton ,  Donald Joseph Merlo ,  Qihua Cai ,  Haley Jo Moon ,  Joel Jay Sheets ,  Aaron Todd Woosley

    发明人： Timothy Denver Hey ,  Thomas Meade ,  Stephanie Love Burton ,  Donald Joseph Merlo ,  Qihua Cai ,  Haley Jo Moon ,  Joel Jay Sheets ,  Aaron Todd Woosley

    IPC分类号： C07K14/00 ,  C07K17/00 ,  A61K38/43 ,  A01N25/00

    CPC分类号： C12N15/8286 ,  C07K14/195 ,  C07K14/24 ,  C07K14/32 ,  C07K2319/00 ,  C07K2319/55 ,  C12N15/62 ,  Y02A40/162

    摘要： The subject invention relates to insecticidal toxin complex (“TC”) fusion proteins and to polynucleotides that encode these fusion proteins. In some embodiments, the invention provide a fusion protein comprising a Class A protein, a Class B protein, and a Class C TC protein fused together to form a single protein. In some other embodiments, the invention provides a fusion protein compromising a Class B and a Class C TC proteins fused together. In the latter embodiments, the BC and CB fusion protein can be used to enhance or potentate the anti-insect activity of a “Toxin A” or Class A protein. The subject invention also includes plants, cells (bacterial and plant cells for example) and seeds that comprise the polynueleotides. The subject invention also includes methods of controlling pests (preferably insects and other plant pests) with fusion proteins of the subject invention.

    摘要翻译： 本发明涉及杀虫毒素复合物（“TC”）融合蛋白和编码这些融合蛋白的多核苷酸。 在一些实施方案中，本发明提供了包含A类蛋白，B类蛋白和C类TC蛋白的融合蛋白，其融合在一起以形成单一蛋白。 在一些其它实施方案中，本发明提供了融合蛋白质，并融合在一起的B类和C类TC蛋白质。 在后一个实施方案中，BC和CB融合蛋白可用于增强或增强“毒素A”或A类蛋白的抗昆虫活性。 本发明还包括植物，细胞（例如细菌和植物细胞）和包含多核苷酸的种子。 本发明还包括用本发明的融合蛋白控制害虫（优选昆虫和其它植物害虫）的方法。

    Insecticidal toxin complex fusion proteins
    9.
    发明申请
    Insecticidal toxin complex fusion proteins 有权
    杀虫毒素复合融合蛋白

    公开(公告)号：US20060168683A1

    公开(公告)日：2006-07-27

    申请号：US11070573

    申请日：2005-03-02

    申请人： Timothy Hey ,  Thomas Meade ,  Stephanie Burton ,  Donald Merlo ,  Qihua Cai ,  Haley Moon ,  Joel Sheets ,  Aaron Woosley

    发明人： Timothy Hey ,  Thomas Meade ,  Stephanie Burton ,  Donald Merlo ,  Qihua Cai ,  Haley Moon ,  Joel Sheets ,  Aaron Woosley

    IPC分类号： A01H1/00 ,  C07K14/415 ,  C12N15/82 ,  C12N5/04

    CPC分类号： C12N15/8286 ,  C07K14/195 ,  C07K14/24 ,  C07K14/32 ,  C07K2319/00 ,  C07K2319/55 ,  C12N15/62 ,  Y02A40/162

    摘要： The subject invention relates to insecticidal toxin complex (“TC”) fusion proteins and to polynucleotides that encode these fusion proteins. The subject invention also includes polynucleotides that encode the subject TC fusion proteins, and vectors comprising said polynucleotides. In some embodiments, the invention provides a fusion protein comprising a Class A protein, a Class B protein, and a Class C TC protein fused together to form a single protein. In some other embodiments, the invention provides a fusion protein comprising a Class B and a Class C TC proteins fused together. In the latter embodiments, the BC or CB fusion protein can be used to enhance or potentiate the anti-insect activity of a “Toxin A” or Class A protein. Heretofore, there was no expectation that such fusion proteins would properly function and retain their activity when fused together. The subject invention advantageously reduces the number of genes needed to transform plants. Thus, the subject invention also includes plants, cells (bacterial and plant cells for example), and seeds that comprise said polynucleotides. Said plants can produce fusion proteins of the subject invention, which convey insect resistance to said plants. The subject invention also includes methods of controlling pests (preferably insects and other plant pests) with fusion proteins of the subject invention.

    摘要翻译： 本发明涉及杀虫毒素复合物（“TC”）融合蛋白和编码这些融合蛋白的多核苷酸。 本发明还包括编码受试者TC融合蛋白的多核苷酸和包含所述多核苷酸的载体。 在一些实施方案中，本发明提供了融合蛋白，其包含一起融合以形成单一蛋白质的A类蛋白质，B类蛋白质和C类TC蛋白质。 在一些其他实施方案中，本发明提供了融合蛋白，其包含融合在一起的B类和C类TC蛋白。 在后一个实施方案中，BC或CB融合蛋白可用于增强或增强“毒素A”或A类蛋白的抗昆虫活性。 迄今为止，没有任何期望，当融合在一起时，这种融合蛋白将适当地起作用并保持其活性。 本发明有利地减少转化植物所需的基因数量。 因此，本发明还包括植物，细胞（例如细菌和植物细胞）和包含所述多核苷酸的种子。 所述植物可产生本发明的融合蛋白，其向所述植物传递昆虫抗性。 本发明还包括用本发明的融合蛋白控制害虫（优选昆虫和其它植物害虫）的方法。

    Mixing and matching TC proteins for pest control
    10.
    发明授权
    Mixing and matching TC proteins for pest control 有权
    混合和匹配TC蛋白用于病虫害防治

    公开(公告)号：US07491698B2

    公开(公告)日：2009-02-17

    申请号：US10754115

    申请日：2004-01-07

    申请人： Timothy D. Hey ,  Amanda D. Schleper ,  Scott A. Bevan ,  Scott B. Bintrim ,  Jon C. Mitchell ,  Ze Sheng Li ,  Weiting Ni ,  Baolong Zhu ,  Donald J. Merlo ,  Patricia C. Apel-Birkhold ,  Thomas Meade

    发明人： Timothy D. Hey ,  Amanda D. Schleper ,  Scott A. Bevan ,  Scott B. Bintrim ,  Jon C. Mitchell ,  Ze Sheng Li ,  Weiting Ni ,  Baolong Zhu ,  Donald J. Merlo ,  Patricia C. Apel-Birkhold ,  Thomas Meade

    IPC分类号： A61K38/16 ,  A01N33/04 ,  C07K14/195

    CPC分类号： C07K14/195 ,  A01N37/46 ,  A01N63/02 ,  C07K14/24 ,  C12N15/8286 ,  Y02A40/162

    摘要： The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdus, and Paenibacillus, can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a “stand-alone” TC protein (from Photorhabdus, Xenorhabdus, or Paenibacillus, for example) is enhanced by one or more TC protein “potentiators” derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will now be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone Xenorhabdus protein toxin as well as a stand-alone Photorhabdus protein toxin. (As one skilled in the art knows, Xenorhabdus toxin proteins tend to be more desirable for controlling lepidopterans while Photorhabdus toxin proteins tend to be more desirable for controlling coleopterans.) This reduces the number of genes, and transformation events, needed to be expressed by a transgenic plant to achieve effective control of a wider spectrum of target pests. Certain preferred combinations of heterologous TC proteins are also disclosed herein. Other objects, advantages, and features of the subject invention will be apparent to one skilled in the art having the benefit of the subject disclosure.

    摘要翻译： 本发明涉及令​​人惊奇的发现，可以从Xenorhabdus，Photorhabdus和Paenibacillus获得的毒素复合物（TC）蛋白质彼此互换使用。 在本发明的特别优选的实施方案中，“独立”TC蛋白（例如，来自Photorhabdus，Xenorhabdus或Paenibacillus的例如）的毒性由一种或多种衍生自以下的源生物体的TC蛋白“增强剂”增强 来源于毒素的不同属。 本领域技术人员将会认识到本公开的益处，这具有广泛的含义并扩大了现在将认识到各种类型的TC蛋白质具有的效用范围。 最重要的优点之一是，本领域技术人员现在将能够使用单一增强剂来增强独立的Xenorhabdus蛋白毒素的活性以及独立的Photorhabdus蛋白毒素。 （如本领域技术人员所知，Xenorhabdus毒素蛋白质倾向于更好地控制鳞翅目，而Photorhabdus毒素蛋白质倾向于更有利于控制鞘翅目）。这减少了需要表达的基因数量和转化事件 一个转基因植物，以实现更广泛的目标害虫的有效控制。 异源TC蛋白的某些优选组合也在本文中公开。 受益于本发明的本发明的其它目的，优点和特征对本领域技术人员而言是显而易见的。