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公开(公告)号：US20090142328A1
公开(公告)日：2009-06-04
申请号：US11906596
申请日：2007-10-03
IPC分类号： A61K38/48
CPC分类号： A61K38/57 , C12Q1/37 , G01N33/57449
摘要： The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
摘要翻译： 本发明提供了通过测定抗白蛋白酶水平来检测/监测组织中肿瘤生长和进展的方法。 还提供了通过施用抗白蛋白酶来抑制角质层糜蛋白酶的活性来治疗患有肿瘤的个体的方法。 具体来说，肿瘤是卵巢癌。
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公开(公告)号：US06602674B1
公开(公告)日：2003-08-05
申请号：US09692820
申请日：2000-10-18
IPC分类号： G01N33574
CPC分类号： A61K38/57 , C12Q1/37 , G01N33/57449
摘要： The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
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3.发明申请公开(公告)号：US20090274618A1
公开(公告)日：2009-11-05
申请号：US11978259
申请日：2007-10-29
IPC分类号： A61K51/00 , C12N15/00 , C12N1/21 , C12N5/06 , C12N5/04 , C12N15/87 , C12N15/82 , C12N15/11 , A61K31/7088 , A61K39/395 , A61K39/00 , C12Q1/37
CPC分类号： C12N9/6424 , A61K39/00 , C12Q1/6851 , C12Q1/6886 , C12Q2600/136 , Y10T436/25
摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
摘要翻译： 本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。 还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。 本发明还提供了抑制TADG-15表达和/或蛋白酶活性的方法，检测TADG-15mRNA和/或蛋白质的方法以及筛选TADG-15抑制剂的方法。 另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。 所描述的方法可用于诊断，治疗和预防癌症，特别是乳腺癌和卵巢癌。
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4.发明授权公开(公告)号：US07939321B2
公开(公告)日：2011-05-10
申请号：US11978259
申请日：2007-10-29
IPC分类号： C12N5/00 , C12N5/02 , C12N5/06 , C12N5/07 , C12N5/071 , C12N5/078 , C12N5/0781 , C12N5/0783 , C12N5/0784 , C12N5/08 , C12N5/10 , G01N1/00
CPC分类号： C12N9/6424 , A61K39/00 , C12Q1/6851 , C12Q1/6886 , C12Q2600/136 , Y10T436/25
摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
摘要翻译： 本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。 还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。 本发明还提供了抑制TADG-15表达和/或蛋白酶活性的方法，检测TADG-15mRNA和/或蛋白质的方法以及筛选TADG-15抑制剂的方法。 另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。 所描述的方法可用于诊断，治疗和预防癌症，特别是乳腺癌和卵巢癌。
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公开(公告)号：US07022821B1
公开(公告)日：2006-04-04
申请号：US09421213
申请日：1999-10-20
CPC分类号： C12N9/6424 , A61K39/00 , C12Q1/6851 , C12Q1/6886 , C12Q2600/136 , Y10T436/25
摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The instant invention also includes a kit containing antibodies for the detection of TADG-15 protein. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
摘要翻译： 本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。 还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。 本发明还提供了抑制TADG-15表达和/或蛋白酶活性的方法，检测TADG-15mRNA和/或蛋白质的方法以及筛选TADG-15抑制剂的方法。 另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。 本发明还包括含有用于检测TADG-15蛋白的抗体的试剂盒。 所描述的方法可用于诊断，治疗和预防癌症，特别是乳腺癌和卵巢癌。
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6.发明授权公开(公告)号：US06649741B1
公开(公告)日：2003-11-18
申请号：US09654600
申请日：2000-09-01
IPC分类号： C07K1600
CPC分类号： C12N9/6424 , A61K39/00 , C12Q1/6851 , C12Q1/6886 , C12Q2600/136 , Y10T436/25
摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis. treatment and prevention of cancer particularly breast and ovarian cancer.
摘要翻译： 本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。 还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。 本发明还提供了抑制TADG-15 mRNA和/或蛋白质的TADG-15表达和/或蛋白酶活性检测方法以及筛选TADG-15抑制剂的方法。 另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。 所述方法在诊断中是有用的。 治疗和预防癌症，特别是乳腺癌和卵巢癌。
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7.发明申请公开(公告)号：US20110212023A1
公开(公告)日：2011-09-01
申请号：US13068264
申请日：2011-05-06
IPC分类号： A61K51/10 , C12N15/63 , C12N5/10 , C12N1/21 , C12N5/07 , C12N5/04 , C12Q1/37 , C07H21/00 , A61K31/7088 , A61K39/395 , A61K39/00 , A61P37/04 , A61P35/00
CPC分类号： C12N9/6424 , A61K39/00 , C12Q1/6851 , C12Q1/6886 , C12Q2600/136 , Y10T436/25
摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
摘要翻译： 本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。 还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。 本发明还提供了抑制TADG-15表达和/或蛋白酶活性的方法，检测TADG-15mRNA和/或蛋白质的方法以及筛选TADG-15抑制剂的方法。 另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。 所描述的方法可用于诊断，治疗和预防癌症，特别是乳腺癌和卵巢癌。
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8.发明授权公开(公告)号：US07291462B2
公开(公告)日：2007-11-06
申请号：US10600187
申请日：2003-06-20
IPC分类号： C12Q1/68 , C12Q1/00 , G01N33/53 , G01N33/574 , G01N33/48 , G01N21/00 , G01N21/75 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , A61K38/00 , C07K14/00
CPC分类号： C12N9/6424 , A61K39/00 , C12Q1/6851 , C12Q1/6886 , C12Q2600/136 , Y10T436/25
摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
摘要翻译： 本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。 还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。 本发明还提供了抑制TADG-15表达和/或蛋白酶活性的方法，检测TADG-15mRNA和/或蛋白质的方法以及筛选TADG-15抑制剂的方法。 另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。 所描述的方法可用于诊断，治疗和预防癌症，特别是乳腺癌和卵巢癌。
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9.发明授权TADG-15: an extracellular serine protease overexpressed in breast and ovarian carcinomas 失效TADG-15：在乳腺和卵巢癌中过表达的细胞外丝氨酸蛋白酶
公开(公告)号：US5972616A
公开(公告)日：1999-10-26
申请号：US27337
申请日：1998-02-20
CPC分类号： C12N9/6424
摘要： The present invention provides a DNA encoding a TADG-15 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-15 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-15 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
摘要翻译： 本发明提供编码TADG-15蛋白质的DNA，其选自：（a）编码TADG-15蛋白质的分离的DNA; （b）与上述（a）的分离的DNA杂交并编码TADG-15蛋白的分离的DNA; 和（c）由于遗传密码的简并性而编码TADG-15蛋白质，密码子序列中与（a）和（b）分离的DNA不同的分离的DNA。 还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。
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公开(公告)号：US08502440B2
公开(公告)日：2013-08-06
申请号：US12989196
申请日：2009-04-10
申请人： Hiroyasu Inoue , Hirotoshi Tanimoto
发明人： Hiroyasu Inoue , Hirotoshi Tanimoto
IPC分类号： H01L51/50
CPC分类号： H01L51/5268 , H01L51/524 , H01L51/5271
摘要： An organic electroluminescent light source device includes, in the following order from a light-emitting surface side, a first transparent electrode layer, a luminescent layer, a second transparent electrode layer, and a reflecting layer, wherein the reflecting layer includes a concavo-convex structure with an average inclination angle of 12 to 45°. An organic electroluminescent light source device includes, in the following order, a first transparent electrode layer, a luminescent layer, a second transparent electrode layer, a diffusing layer, and a reflecting-scattering layer, wherein the diffusing layer has a concavo-convex surface including a concavo-convex structure with an average inclination angle of 17 to 45°.
摘要翻译： 一种有机电致发光光源装置，从发光面侧依次包括第一透明电极层，发光层，第二透明电极层和反射层，其中反射层包括凹凸 平均倾角为12〜45°的结构。 有机电致发光光源装置按照以下顺序包括第一透明电极层，发光层，第二透明电极层，漫射层和反射散射层，其中漫射层具有凹凸表面 包括平均倾斜角为17°〜45°的凹凸结构。
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