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1.发明授权
公开(公告)号：US5217952A
公开(公告)日：1993-06-08
申请号：US794698
申请日：1991-11-20
申请人： Tohru Kino , Motoaki Nishikawa , Masami Ezaki , Sumio Kiyoto , Masakuni Okuhara , Shigehiro Takase , Satoshi Okada , Nobuharu Shigematsu
发明人： Tohru Kino , Motoaki Nishikawa , Masami Ezaki , Sumio Kiyoto , Masakuni Okuhara , Shigehiro Takase , Satoshi Okada , Nobuharu Shigematsu
CPC分类号： C07K7/06 , C12P1/06 , C12R1/465 , A61K38/00 , Y10S514/826
摘要： This invention relates to the novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof which have pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain.
摘要翻译： 本发明涉及具有药理活性，特别是治疗和/或预防哮喘和/或疼痛的新型肽WS-9326A，WS-9326B及其衍生物和药学上可接受的盐。
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公开(公告)号：US5436140A
公开(公告)日：1995-07-25
申请号：US225915
申请日：1994-04-11
申请人： Tohru Kino , Motoaki Nishikawa , Masami Ezaki , Sumio Kiyoto , Masakuni Okuhara , Shigehiro Takase , Satoshi Okada , Nobuharu Shigematsu
发明人： Tohru Kino , Motoaki Nishikawa , Masami Ezaki , Sumio Kiyoto , Masakuni Okuhara , Shigehiro Takase , Satoshi Okada , Nobuharu Shigematsu
摘要： The novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof have useful pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain. A method for the production of the peptides WS-9326A and WS-9326B and derivatives thereof using Streptomyces violaceoniger No. 9326 in a biologically pure form is described herein.
摘要翻译： 新型肽WS-9326A，WS-9326B及其衍生物和药学上可接受的盐具有有用的药理活性，特别是用于治疗和/或预防哮喘和/或疼痛。 本文描述了以生物纯的形式生产肽WS-9326A和WS-9326B及其衍生物的方法。
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公开(公告)号：US5187195A
公开(公告)日：1993-02-16
申请号：US543437
申请日：1990-06-26
申请人： Nobutaka Oohata , Motoaki Nishikawa , Sumio Kiyoto , Shigehiro Takase , Keiji Hemmi , Hidetsugu Murai , Masakuni Okuhara
发明人： Nobutaka Oohata , Motoaki Nishikawa , Sumio Kiyoto , Shigehiro Takase , Keiji Hemmi , Hidetsugu Murai , Masakuni Okuhara
IPC分类号： C12P13/02 , A61K31/16 , A61K31/195 , A61K31/215 , A61K38/00 , A61P9/00 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , C07C323/25 , C07C323/41 , C07C323/59 , C07C323/60 , C07D209/20 , C07K5/06 , C07K5/083 , C12N1/20 , C12P13/00 , C12R1/38 , C12R1/465
CPC分类号： C12P13/001 , C07C323/59 , C07C323/60 , C07K5/0606 , C07K5/081 , A61K38/00 , C07C2103/42 , Y10S514/929
摘要： Anthraquinone compounds of the formula: ##STR1## wherein: R.sup.1 is hydrogen, hydroxy or acyloxy,R.sup.2 is hydrogen or acyl,R.sup.3 is acyl,R.sup.4 is hydrogen or acyl,R.sup.5 is hydrogen or acyl,R.sup.6 is hydrogen or acyl, andR.sup.7 is hydrogen or acylhave been found to possess endothelin antagonistic properties and are producible by various synthetic and fermentation processes.
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公开(公告)号：US4680178A
公开(公告)日：1987-07-14
申请号：US631244
申请日：1984-07-16
申请人： Sumio Kiyoto , Masakuni Okuhara , Eiko Kino , Hirokazu Tanaka , Hatsuo Aoki , Masanobu Kohsaka , Hiroshi Imanaka
发明人： Sumio Kiyoto , Masakuni Okuhara , Eiko Kino , Hirokazu Tanaka , Hatsuo Aoki , Masanobu Kohsaka , Hiroshi Imanaka
IPC分类号： C07D493/22 , C12P1/02 , A61K35/70 , A61K35/72 , A61K31/42
CPC分类号： C07D493/22 , C12P1/02 , C12R1/845
摘要： The invention relates to a pharmaceutical composition for treating lymphocytic leukemia, melanoma or mammary carcinoma comprising an effective amount of FR-900216.
摘要翻译： 本发明涉及用于治疗淋巴细胞白血病，黑素瘤或乳腺癌的药物组合物，其包含有效量的FR-900216。
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5.发明授权Biologically active WS 6049 substances, a process for the production thereof and their pharmaceutical compositions 失效生物活性WS 6049物质，其制备方法及其药物组合物
公开(公告)号：US4578271A
公开(公告)日：1986-03-25
申请号：US491170
申请日：1983-05-03
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , A61P35/00 , C12N1/20 , C12P1/04 , C12P1/06 , C12P13/00 , C12R1/03 , A61K35/00
CPC分类号： C12R1/03 , C12P1/06 , Y10S435/825
摘要： Novel compounds designated as WS 6049-A and WS 6049-B are disclosed, as well as compositions containing the compounds thereof, a method of treating microbial infections, a method of prolonging the survival time of the patient with lymphocytic leukemia by administering the compounds thereof, and a process for making the WS 6049 substances, are disclosed. As indicated above, the novel compounds have antimicrobial and antileukemic activities which make them useful against a variety of pathogenic microorganisms and leukemic tumors.
摘要翻译： 公开了称为WS 6049-A和WS 6049-B的新化合物，以及含有其化合物的组合物，治疗微生物感染的方法，通过施用其化合物延长患有淋巴细胞白血病的患者的存活时间的方法 ，以及制备WS 6049物质的方法。 如上所述，新化合物具有抗微生物和抗白血病活性，使其可用于各种致病微生物和白血病肿瘤。
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6.发明申请NOVEL METHOD FOR TREATING CHRONIC SEVERE HEART FAILURE BY USING INSULIN-LIKE GROWTH FACTOR-1 (IGF-1) 审中-公开通过使用胰岛素样生长因子-1（IGF-1）治疗慢性严重心脏衰竭的新方法公开(公告)号：US20090012499A1
公开(公告)日：2009-01-08
申请号：US11815684
申请日：2006-02-06
申请人： Kunio Miyatake , Kazuo Komamura , Sumio Kiyoto
发明人： Kunio Miyatake , Kazuo Komamura , Sumio Kiyoto
CPC分类号： A61K38/30
摘要： The present invention relates to novel method for treating chronic severe heart failure by using insulin-like growth factor-1 (IGF-1). More specifically, the present invention relates to method for improving cardiovascular function and symptoms in a patient with chronic severe heart failure by administering IGF-1 to the patient for a certain period, wherein no options for treating the disorder the patient remain other than heart transplantation.
摘要翻译： 本发明涉及通过使用胰岛素样生长因子-1（IGF-1）治疗慢性严重心力衰竭的新方法。 更具体地，本发明涉及通过向患者施用IGF-1一段时间来改善患有慢性严重心力衰竭的患者的心血管功能和症状的方法，其中除了心脏移植之外，治疗病症的方法不存在 。
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公开(公告)号：US4670259A
公开(公告)日：1987-06-02
申请号：US813065
申请日：1985-12-24
IPC分类号： C12N1/16 , A61K36/06 , A61K36/07 , A61P35/00 , C07G11/00 , C12N1/14 , C12P1/02 , C12R1/645 , A61K35/70 , A61K35/72
CPC分类号： C12P1/02
摘要： The invention relates to a new compound, designated FR-68504. The compound has antitimor activities and is effective in the treatment of various tumors in both human beings and animals.There is also provided a process for preparing FR-68504 compound which comprises culturing a FR-68504 producing strain belonging to the genus Amauroascus in a nutrient medium.Pharmaceutical composition comprising FR-68504 as an active ingredient is also described.
摘要翻译： 本发明涉及一种名为FR-68504的新化合物。 该化合物具有抗肿瘤活性，在人和动物的各种肿瘤治疗中均有效。 还提供了制备FR-68504化合物的方法，该方法包括在营养培养基中培养属于阿莫罗氏菌属的FR-68504生产菌株。 还描述了包含FR-68504作为活性成分的药物组合物。
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