公开(公告)号：US20180325946A1

公开(公告)日：2018-11-15

申请号：US16043395

申请日：2018-07-24

Applicant: Tokushima University

Inventor： Minoru Ueda ,  Yoichi Yamada ,  Katsumi Ebisawa ,  Akihito Yamamoto ,  Kiyoshi Sakai ,  Kohki Matsubara ,  Hisashi Hattori ,  Masahiko Sugiyama ,  Takanori Inoue

IPC: A61K35/12 ,  A61K38/30 ,  A61K35/545 ,  A61K38/18 ,  C12N5/0775 ,  A61K35/32 ,  A61K35/28 ,  A61K35/30

CPC classification number: A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/32 ,  A61K35/545 ,  A61K38/18 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/30 ,  C12N5/0664 ,  A61K2300/00

Abstract: The present invention provides a damaged part treatment composition for repairing a damaged part of a target tissue that includes a stem cell-conditioned medium obtained by culturing stem cells; a damaged part treatment method for repairing or restoring a damaged part of a target tissue that includes administering the damaged part treatment composition to a patient having the target tissue for the damaged part treatment composition in an amount therapeutically effective for repairing the damaged part of the target tissue; a method of treating cerebral infarction that includes administering the damaged part treatment composition to a cerebral infarct patient in an amount effective for repairing a damaged part of the brain; and a method of treating a CNS disease that includes administering, as a CNS disease treatment composition, the damaged part treatment composition to a CNS disease patient in a therapeutically effective amount.

公开(公告)号：US11000572B2

公开(公告)日：2021-05-11

申请号：US16671497

申请日：2019-11-01

Applicant: TOKUSHIMA UNIVERSITY

Inventor： Akihito Yamamoto ,  Minoru Ueda ,  Kohki Matsubara ,  Akio Suzumura ,  Koichi Furukawa ,  Yoshihiro Matsushita ,  Hirotaka Wakayama ,  Nobunori Takahashi ,  Shin Tsunekawa ,  Takako Izumoto

IPC: A61K38/19 ,  C12N5/0786 ,  A61K45/06 ,  A61K31/737 ,  A61K38/17

Abstract: A composition having tissue repair activity, which is capable of promoting reactions associated with tissue repair, contains at least one selected from the group consisting of a first component that is a protein having a monocyte chemotactic protein-1 (MCP-1) activity, a second component that is a protein having the extracellular domain activity of sialic acid-binding immunoglobulin-type lectin-9 (Siglec-9), and a third component that is at least one of chondroitin sulfate and chondroitin sulfate proteoglycan.

公开(公告)号：US10507230B2

公开(公告)日：2019-12-17

申请号：US15938839

申请日：2018-03-28

Applicant: TOKUSHIMA UNIVERSITY

Inventor： Akihito Yamamoto ,  Minoru Ueda ,  Kohki Matsubara ,  Akio Suzumura ,  Koichi Furukawa ,  Yoshihiro Matsushita ,  Hirotaka Wakayama ,  Nobunori Takahashi ,  Shin Tsunekawa ,  Takako Izumoto

IPC: A61K38/19 ,  C12N5/00 ,  C12N5/0786 ,  A61K45/06 ,  A61K31/737 ,  A61K38/17

Abstract: A composition having tissue repair activity, which is capable of promoting reactions associated with tissue repair, contains at least one selected from the group consisting of a first component that is a protein having a monocyte chemotactic protein-1 (MCP-1) activity, a second component that is a protein having the extracellular domain activity of sialic acid-binding immunoglobulin-type lectin-9 (Siglec-9), and a third component that is at least one of chondroitin sulfate and chondroitin sulfate proteoglycan.