公开(公告)号：US4141790A

公开(公告)日：1979-02-27

申请号：US796194

申请日：1977-05-12

申请人： Tomizo Niwa ,  Chuhei Nojiri ,  Hitoshi Goi ,  Shinji Miyado ,  Fumio Kai ,  Shigeo Seki ,  Yujiro Yamada ,  Taro Niida

发明人： Tomizo Niwa ,  Chuhei Nojiri ,  Hitoshi Goi ,  Shinji Miyado ,  Fumio Kai ,  Shigeo Seki ,  Yujiro Yamada ,  Taro Niida

IPC分类号： C07D501/20 ,  C07D501/18 ,  C12P35/02 ,  C12D9/04

CPC分类号： C12P35/02 ,  Y10S435/911 ,  Y10S435/913

摘要： Compounds are provided having the general formula I: ##STR1## wherein X represents an hydroxyl group, an acetoxy group or a thiosulfuric acid residue. The formula I compounds are prepared from compounds of the general formula II: ##STR2## wherein R.sub.1 represents hydrogen, a lower alkanoyl group, an arylalkanoyl group, an alkoxycarbonyl group, a lower haloalkoxycarbonyl group, a substituted or unsubstituted aroyl group, a N-arylcarbamoyl group of a substituted or unsubstituted aryl group; R.sub.2 either represents hydrogen or, together with the ##STR3## group, represents a phthalimido group; and X represents an hydroxyl group, an acetoxy group or a thiosulfuric acid residue, or their metal salts or their salts with organic bases, by causing the culture of a cephalosporin C acylase-producing strain of a microorganism, especially a mold, fungus, or the secondary preparation therefrom, to act on the latter compounds II in the presence of an aqueous medium.

摘要翻译： 提供具有通式I的化合物：其中X表示羟基，乙酰氧基或硫代硫酸残基。 式I化合物由通式II的化合物制备：其中R 1表示氢，低级烷酰基，芳基烷酰基，烷氧基羰基，低级卤代烷氧基羰基，取代或未取代的芳酰基，N 取代或未取代的芳基的芳基氨基甲酰基; R2或者表示氢，或者与组一起代表苯二甲酰亚氨基; X表示羟基，乙酰氧基或硫代硫酸残基，或其与有机碱的金属盐或其盐，通过使微生物的头孢菌素C酰基转移酶生产菌株，特别是霉菌，真菌或 其中的二次制剂在水性介质的存在下作用于后面的化合物II。

公开(公告)号：US4258184A

公开(公告)日：1981-03-24

申请号：US020224

申请日：1979-03-13

申请人： Fumio Kai ,  Takashi Tsuruoka ,  Osamu Makabe ,  Shigeharu Inouye ,  Hitoshi Ikeda ,  Yuzo Kazuno ,  Shokichi Nakajima ,  Shigeo Seki ,  Taro Niida

发明人： Fumio Kai ,  Takashi Tsuruoka ,  Osamu Makabe ,  Shigeharu Inouye ,  Hitoshi Ikeda ,  Yuzo Kazuno ,  Shokichi Nakajima ,  Shigeo Seki ,  Taro Niida

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/36 ,  C07D501/56

CPC分类号： C07D501/36 ,  A61K31/545

摘要： Novel cephalosporin derivatives having formulae (V) and (III): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.8 and A are defined as in the specification.

摘要翻译： 具有式（V）和（III）的新型头孢菌素衍生物：其中R 1，R 2，R 3，R 4，R 8和A如说明书中所定义。

公开(公告)号：US4357331A

公开(公告)日：1982-11-02

申请号：US104220

申请日：1979-12-17

申请人： Katsuyoshi Iwamatsu ,  Shigeharu Inoue ,  Keinosuke Miyauchi ,  Shinichi Kondo ,  Shigeo Seki ,  Yujiro Yamada

发明人： Katsuyoshi Iwamatsu ,  Shigeharu Inoue ,  Keinosuke Miyauchi ,  Shinichi Kondo ,  Shigeo Seki ,  Yujiro Yamada

IPC分类号： A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/36 ,  C07D501/40 ,  C07D501/57 ,  C07D501/60

CPC分类号： C07D501/57

摘要： A 7.alpha.-methoxycephalosporin derivative represented by the formula (I): ##STR1## wherein R.sub.1 represents a heterocyclic ring or an --S-- heterocyclic ring; R.sub.2 represents a hydrogen atom, a carboxy group or a --COOR.sub.5 group wherein R.sub.5 represents a lower alkyl group, a dialkylamino-lower alkyl group or a ##STR2## group wherein R.sub.6 represents a lower alkyl group, a lower acyl group or a lower alkoxycarbonyl group and Y represents a hydrogen atom or a lower alkyl group; R.sub.3 represents a hydrogen atom, a carbamoyl group or a lower acyl group; R.sub.4 represents a hydrogen atom, a lower alkyl group, a dialkylamino-lower alkyl group or a ##STR3## group wherein R.sub.6 and Y are defined as above; A and B, which may be the same or different, each represents a straight chain or branched chain alkylene group having 1 to 5 carbon atoms; and x represents 0 or 1; or a pharmaceutically acceptable salt thereof and a process for producing the same.

摘要翻译： 由式（I）表示的7α-甲氧头孢菌素衍生物：其中R 1表示杂环或-S-杂环; R2表示氢原子，羧基或-COOR5基团，其中R5表示低级烷基，二烷基氨基 - 低级烷基或其中R6表示低级烷基，低级酰基或低级烷氧基羰基 基团，Y表示氢原子或低级烷基; R3表示氢原子，氨基甲酰基或低级酰基; R4表示氢原子，低级烷基，二烷基氨基 - 低级烷基或基团，其中R6和Y如上定义; A和B可以相同或不同，各自表示具有1至5个碳原子的直链或支链亚烷基; x表示0或1; 或其药学上可接受的盐及其制备方法。

公开(公告)号：US4256744A

公开(公告)日：1981-03-17

申请号：US009028

申请日：1979-02-02

申请人： Shigeo Seki ,  Yashuharu Sekizawa ,  Fumio Kai ,  Yukio Suzuki ,  Michiaki Iwata ,  Tetsuro Watanabe

发明人： Shigeo Seki ,  Yashuharu Sekizawa ,  Fumio Kai ,  Yukio Suzuki ,  Michiaki Iwata ,  Tetsuro Watanabe

IPC分类号： A01N43/80 ,  C07D275/06 ,  C07D277/62

CPC分类号： C07D275/06 ,  A01N43/80

摘要： This invention relates to novel compounds of the general formula (I): ##STR1## wherein A represents ##STR2## in which B represents a ring-forming residue of a 5- or 6-membered carbon-containing heterocycling ring containing at least one nitrogen atom and which may further contain an oxygen atom in the ring, and R.sub.1 and R.sub.2 are the same or different and each represents an alkyl group having from 1 to 6 carbon atoms, a phenyl group, a phenyl group substituted with an alkyl or alkoxy group having from 1 to 4 carbon atoms or a halogen atom, a benzyl group or a benzyl group substituted with an alkyl or alkoxy group having from 1 to 4 carbon atoms or a halogen atom; n represents 0 or an integer of from 1 to 4 corresponding to the number of X substituents; and X represents a halogen atom, a nitro group, a carboxyl group or a carbamoyl group and when two or more X substituents are present they may be the same or different; agents for controlling agricultural and horticultural plant diseases which contain these novel compounds as active ingredients; and to processes for preparing the novel compounds of formula (I).

摘要翻译： 本发明涉及通式（I）的新化合物：其中A代表“IMAGE”，其中B代表含有5或6元含碳杂环的成环残基， 至少一个氮原子，并且其可以在环中进一步含有氧原子，并且R 1和R 2相同或不同，并且各自表示具有1至6个碳原子的烷基，苯基，被烷基取代的苯基 或具有1至4个碳原子的烷氧基或卤素原子，苄基或被具有1至4个碳原子的烷基或烷氧基或卤素原子取代的苄基; n表示0或对应于X取代基数的1至4的整数; X表示卤原子，硝基，羧基或氨基甲酰基，当存在两个以上X取代基时，它们可以相同或不同; 用于控制含有这些新化合物作为活性成分的农业和园艺植物病害的药剂; 以及制备式（I）的新型化合物的方法。

公开(公告)号：US4113944A

公开(公告)日：1978-09-12

申请号：US588555

申请日：1975-06-19

申请人： Fumio Kai ,  Toshinori Saito ,  Shigeo Seki ,  Toyoaki Kawasaki

发明人： Fumio Kai ,  Toshinori Saito ,  Shigeo Seki ,  Toyoaki Kawasaki

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/04 ,  C07D501/24 ,  C07D501/36 ,  C07D501/40 ,  C07D501/42 ,  C07D501/46 ,  C07D501/48 ,  C07D501/54 ,  C07D501/56 ,  C07D501/60

CPC分类号： C07D501/36

摘要： A cephalosporin compound represented by the formula (I) or (I') ##STR1## wherein R.sup.1 represents a phenyl group, a 2-thienyl group or a phenoxy group; R.sup.2 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may be substituted with a phenyl group, an alkoxy group having 1 to 4 carbon atoms or a halogen atom, or a phenyl group which may be substituted with one or two groups selected from the group consisting of a halogen atom, a nitro group, an alkyl group having 1 to 4 carbon atoms and an alkoxy group having 1 to 4 carbon atoms; R.sup.3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may be substituted with a monoalkylamino group having 1 to 4 carbon atoms in the alkyl moiety thereof, a dialkylamino group having 1 to 4 carbon atoms in each alkyl moiety thereof, a halogen atom or a phenyl group which may be substituted with one to three groups selected from the group consisting of a halogen atom, a nitro group, an alkyl group having 1 to 4 carbon atoms and an alkoxy group having 1 to 4 carbon atoms; R.sup.4 represents an alkyl group having 1 to 4 carbon atoms; A has up to 15 carbon atoms and represents a straight or branched chain alkylene group, a straight or branched chain alkenylene group, a straight or branched chain alkadienylene group or a phenylene group, and n is 0 or 1; or the salt thereof; and a process for preparing the same.

公开(公告)号：US3932668A

公开(公告)日：1976-01-13

申请号：US531415

申请日：1974-12-10

申请人： Yasuharu Sekizawa ,  Shigeo Seki ,  Bunzo Nomiya ,  Takemi Koeda ,  Fumio Kai ,  Naotoshi Akai ,  Yasushi Yusa ,  Fuguaki Fukuyasu

发明人： Yasuharu Sekizawa ,  Shigeo Seki ,  Bunzo Nomiya ,  Takemi Koeda ,  Fumio Kai ,  Naotoshi Akai ,  Yasushi Yusa ,  Fuguaki Fukuyasu

IPC分类号： A23K1/16 ,  A23K1/18 ,  A61K31/08

CPC分类号： A23K50/30 ,  A23K20/105

摘要： Novel alkyl 2,3,3-triiodoallyl ethers useful as disinfectants are provided by an addition reaction of alkyl-3-iodo-2-propinyl ethers with iodine. The starting alkyl-3-iodo-2-propinyl ethers can be prepared by a new process comprising an alkylation of propargyl alcohol with an alkyl sulfate or alkyl sulfonate in the presence of an alkali, followed by monoiodization of the resulting alkyl-2-propinyl ether. This invention also provides a composition comprising alkyl 2,3,3-triiodoalkyl ethers useful as a poultry feed additive having growth increasing effects and for treating swine scours.

摘要翻译： 用作消毒剂的新型烷基2,3,3-三碘代烯丙基醚通过烷基-3-碘-2-丙炔基醚与碘的加成反应来提供。 起始的烷基-3-碘-2-丙炔基醚可以通过一种新方法制备，该方法包括在碱存在下用炔丙醇与烷基硫酸盐或烷基磺酸盐烷基化，然后将所得的烷基-2-丙炔基 醚。 本发明还提供一种组合物，其包含可用作具有生长增加作用的禽饲料添加剂的烷基2,3,3-三碘烷基醚和用于治疗猪冲洗液的组合物。

公开(公告)号：US5774068A

公开(公告)日：1998-06-30

申请号：US560575

申请日：1995-11-20

申请人： Shigeo Seki

发明人： Shigeo Seki

IPC分类号： G01D5/245 ,  H03M1/28 ,  H03M1/30 ,  G08C19/00

CPC分类号： G01D5/2455 ,  H03M1/282 ,  H03M1/308

摘要： A code plate has an m-bit signal track read out in parallel for providing the starting position of an AC servo motor for commencing rotation when power is first turned ON. An n-bit signal track accompanied by an incremental signal track is provided on the code plate with the n-bit track read out serially, converted to pure binary in parallel, and used once rotation of the servo motor commences to provide the initial absolute value of the encoder. To this n-bit initial value is added signals from the incremental track upon continued rotation of the code plate.

摘要翻译： 代码板具有并行读出的m位信号轨道，用于在电源首次接通时提供用于开始旋转的AC伺服电动机的起始位置。 伴随着增量信号轨迹的n位信号轨迹被提供在码板上，其中n位磁道串行读出，并行转换成纯二进制，并且一旦伺服电动机的旋转开始提供初始绝对值， 的编码器。 对于该n位初始值，在代码板继续旋转时，从增量轨道添加信号。

公开(公告)号：US4195170A

公开(公告)日：1980-03-25

申请号：US880401

申请日：1978-02-23

申请人： Hamao Umezawa ,  Sumio Umezawa ,  Shigeo Seki ,  Shunzo Fukatsu ,  Shuntaro Yasuda

发明人： Hamao Umezawa ,  Sumio Umezawa ,  Shigeo Seki ,  Shunzo Fukatsu ,  Shuntaro Yasuda

IPC分类号： C07H15/236 ,  C07H15/22

CPC分类号： C07H15/234 ,  Y02P20/55

摘要： New routes are provided for the synthesis of 3',4'-dideoxykanamycin B which is effective in inhibiting kanamycin-resistant organisms from kanamycin B through new intermediate, of which a fundamental process comprises a new reaction of a 3',4'-epoxy derivative of amino- and hydroxyl-protected kanamycin B with a xanthate to form a corresponding 3',4'-dideoxy-3'-eno derivative followed by removal of the amino- and hydroxyl-protecting groups thereof and by hydrogenation of the resulting 3',4'-dideoxy-3'-eno-kanamycin B. A 3',4'-episulfide derivative corresponding to the 3',4'-epoxy derivative which is formed as second product in the reaction of 3',4'-epoxy derivative with xanthate is also used as intermediate for the preparation of 3',4'-dideoxykanamycin B.

摘要翻译： 提供了用于合成3'，4'-双脱氧卡那霉素B的新途径，其通过新的中间体有效抑制卡那霉素B的卡那霉素抗性生物，其中基本方法包括3'，4'-环氧基 氨基和羟基保护的卡那霉素B与黄原酸酯的衍生物形成相应的3'，4'-二脱氧-3'-烯衍生物，然后除去其氨基和羟基保护基团，并通过氢化得到的3 '，4'-二脱氧-3'-烯 - 卡那霉素B.对应于3'，4'-环氧衍生物的3'，4'-环硫化物衍生物，其在3'，4' 含有黄原酸酯的环氧衍生物也用作制备3'，4'-双脱氧卡那霉素B的中间体。

公开(公告)号：US3963712A

公开(公告)日：1976-06-15

申请号：US350199

申请日：1973-04-11

申请人： Masao Koyama ,  Shigeo Seki

发明人： Masao Koyama ,  Shigeo Seki

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/10 ,  C07D501/14

CPC分类号： C07D501/10 ,  C07D501/14

摘要： A novel ester of 7-acylamido-3-methyl-cepham-4-carboxylic acid derivative and a process for the preparation thereof which comprises reacting penicillin sulfoxide ester with the metal halide, and a novel 7-acylamido-3-methyl-cepham-4-carboxylic acid derivative and a process for the preparation thereof which comprises reacting penicillin sulfoxide ester with the metal halide and decomposing the resultant in a reductive atmosphere.

摘要翻译： 一种7-酰基氨基-3-甲基 - 头孢烯-4-羧酸衍生物的新型酯及其制备方法，其包括使青霉素亚砜酯与金属卤化物反应，以及新的7-酰基氨基-3-甲基 - 头孢烯-4-羧酸衍生物， 4-羧酸衍生物及其制备方法，其包括使青霉素亚砜酯与金属卤化物反应并在还原气氛中分解所得物。

公开(公告)号：US4225706A

公开(公告)日：1980-09-30

申请号：US898613

申请日：1978-04-21

申请人： Shigeo Seki ,  Ken Nishihata ,  Satoru Nakabayashi ,  Toshinori Saito ,  Hitoshi Ikeda ,  Nobuo Itoh ,  Shokichi Nakajima ,  Shunzo Fukatsu

发明人： Shigeo Seki ,  Ken Nishihata ,  Satoru Nakabayashi ,  Toshinori Saito ,  Hitoshi Ikeda ,  Nobuo Itoh ,  Shokichi Nakajima ,  Shunzo Fukatsu

IPC分类号： A61K20060101 ,  C07D501/04 ,  C07D501/20 ,  C07D501/22 ,  C07D501/26 ,  C07D501/34

CPC分类号： C07D501/20 ,  Y02P20/55

摘要： A novel ester of a cephem compound having a carboxyl group at the 4-position in the nucleus; a process for preparing the same by reacting a cephem carboxylic acid or its salt with a halogenide; and a method for removing the protective group for the carboxyl group in the nucleus of a cephem compound by contacting it with an alcohol, or with an organic solvent in the presence of a Lewis acid.

摘要翻译： 一种在细胞核中4位具有羧基的头孢烯化合物的新型酯; 通过使头孢烯羧酸或其盐与卤化物反应来制备该方法; 以及通过使其与醇或与有机溶剂在路易斯酸的存在下接触来除去头孢烯化合物的核中的羧基的保护基的方法。