利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.011 秒)

    Process for the preparation of 7-amino-cephem compounds using mold fungi
    3.
    发明授权
    Process for the preparation of 7-amino-cephem compounds using mold fungi 失效
    使用霉菌制备7-氨基头孢烯化合物的方法

    公开(公告)号：US4141790A

    公开(公告)日：1979-02-27

    申请号：US796194

    申请日：1977-05-12

    申请人： Tomizo Niwa ,  Chuhei Nojiri ,  Hitoshi Goi ,  Shinji Miyado ,  Fumio Kai ,  Shigeo Seki ,  Yujiro Yamada ,  Taro Niida

    发明人： Tomizo Niwa ,  Chuhei Nojiri ,  Hitoshi Goi ,  Shinji Miyado ,  Fumio Kai ,  Shigeo Seki ,  Yujiro Yamada ,  Taro Niida

    IPC分类号： C07D501/20 ,  C07D501/18 ,  C12P35/02 ,  C12D9/04

    CPC分类号： C12P35/02 ,  Y10S435/911 ,  Y10S435/913

    摘要： Compounds are provided having the general formula I: ##STR1## wherein X represents an hydroxyl group, an acetoxy group or a thiosulfuric acid residue. The formula I compounds are prepared from compounds of the general formula II: ##STR2## wherein R.sub.1 represents hydrogen, a lower alkanoyl group, an arylalkanoyl group, an alkoxycarbonyl group, a lower haloalkoxycarbonyl group, a substituted or unsubstituted aroyl group, a N-arylcarbamoyl group of a substituted or unsubstituted aryl group; R.sub.2 either represents hydrogen or, together with the ##STR3## group, represents a phthalimido group; and X represents an hydroxyl group, an acetoxy group or a thiosulfuric acid residue, or their metal salts or their salts with organic bases, by causing the culture of a cephalosporin C acylase-producing strain of a microorganism, especially a mold, fungus, or the secondary preparation therefrom, to act on the latter compounds II in the presence of an aqueous medium.

    摘要翻译： 提供具有通式I的化合物：其中X表示羟基，乙酰氧基或硫代硫酸残基。 式I化合物由通式II的化合物制备：其中R 1表示氢，低级烷酰基，芳基烷酰基，烷氧基羰基，低级卤代烷氧基羰基，取代或未取代的芳酰基，N 取代或未取代的芳基的芳基氨基甲酰基; R2或者表示氢，或者与组一起代表苯二甲酰亚氨基; X表示羟基，乙酰氧基或硫代硫酸残基，或其与有机碱的金属盐或其盐，通过使微生物的头孢菌素C酰基转移酶生产菌株，特别是霉菌，真菌或 其中的二次制剂在水性介质的存在下作用于后面的化合物II。