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1.发明申请PRIMER AND PROBE FOR DETECTING CHLAMYDIA TRACHOMATIS, AND METHOD FOR DETECTING CHLAMYDIA TRACHOMATIS USING SAME 有权用于检测氯氰菊酯培养基的检测和检测方法，以及使用该方法检测氯林飞蓟马的方法公开(公告)号：US20130059306A1
公开(公告)日：2013-03-07
申请号：US13636250
申请日：2011-03-17
申请人： Tomokazu Ishikawa , Hiromi Kumon
发明人： Tomokazu Ishikawa , Hiromi Kumon
CPC分类号： C12Q1/689
摘要： The present invention relates to an oligonucleotide which is designed on the basis of a nucleotide sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2 and hybridizes with the endogenous plasmid gene of Chlamydia trachomatis, oligonucleotide primer and probe for detecting Chlamydia trachomatis, the detection method of Chlamydia trachomatis using said primer and probe, and a primer for detecting Chlamydia trachomatis of said oligonucleotide or the use to a probe design.
摘要翻译： 本发明涉及基于SEQ ID NO：1或SEQ ID NO：2所示核苷酸序列设计的寡核苷酸，并与沙眼衣原体的内源质粒基因，用于检测沙眼衣原体的寡核苷酸引物和探针杂交， 使用所述引物和探针的沙眼衣原体的检测方法和用于检测所述寡核苷酸的沙眼衣原体的引物或用于探针设计的引物。
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2.发明申请PRIMER AND PROBE FOR DETECTING CHLAMYDOPHILA CAVIAE, AS WELL AS A CHLAMYDOPHILA CAVIAE DETECTION METHOD USING THE SAME 审中-公开用于检测青蒿素的预处理和检测方法，作为使用其的氯胺酮CAVIAE检测方法公开(公告)号：US20100323365A1
公开(公告)日：2010-12-23
申请号：US12866730
申请日：2009-02-03
申请人： Tomokazu Ishikawa , Koichiro Wada , Hiromi Kumon
发明人： Tomokazu Ishikawa , Koichiro Wada , Hiromi Kumon
CPC分类号： C12Q1/689
摘要： Provided are a novel primer and a probe for the detection of Chlamydophila caviae which can exclude any false positive result for the diagnosis, as well as a method for detecting Chlamydophila caviae more simply, rapidly and with high accuracy using the same.According to the method for detection of Chlamydophila caviae using the primer and/or the probe of the present invention, the detection of Chlamydophila caviae can be performed more rapidly and with high precision compared with a conventional bacterial species identification method performed by culture examination and the like. In addition, by using the detection method of the present invention, the Chlamydophila caviae itself can also be quantified.
摘要翻译： 提供了一种用于检测衣原体鱼眼的新型引物和探针，其可以排除任何诊断的假阳性结果，以及更简单，快速且高精度地检测衣原体鱼眼的方法。 根据使用本发明的引物和/或探针的检测沙眼衣原体的方法，与通过培养检查进行的常规细菌种类鉴定方法相比，可以更快速且更高精度地进行沙眼衣原体的检测， 喜欢。 此外，通过使用本发明的检测方法，也可以量化沙眼衣原体本身。
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3.发明授权Primer and probe for detecting chlamydia trachomatis, and method for detecting chlamydia trachomatis using same 有权用于检测沙眼衣原体的引物和探针，以及使用其检测沙眼衣原体的方法公开(公告)号：US09458513B2
公开(公告)日：2016-10-04
申请号：US13636250
申请日：2011-03-17
申请人： Tomokazu Ishikawa , Hiromi Kumon
发明人： Tomokazu Ishikawa , Hiromi Kumon
CPC分类号： C12Q1/689
摘要： The present invention relates to an oligonucleotide which is designed on the basis of a nucleotide sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2 and hybridizes with the endogenous plasmid gene of Chlamydia trachomatis, oligonucleotide primer and probe for detecting Chlamydia trachomatis, the detection method of Chlamydia trachomatis using said primer and probe, and a primer for detecting Chlamydia trachomatis of said oligonucleotide or the use to a probe design.
摘要翻译： 本发明涉及基于SEQ ID NO：1或SEQ ID NO：2所示核苷酸序列设计的寡核苷酸，并与沙眼衣原体的内源质粒基因，用于检测沙眼衣原体的寡核苷酸引物和探针杂交， 使用所述引物和探针的沙眼衣原体的检测方法和用于检测所述寡核苷酸的沙眼衣原体的引物或用于探针设计的引物。
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4.发明授权Pharmaceutical composition for treating or preventing cancer by inducing dendritic cell-like differentiation from monocytes to improve anticancer immune activity 有权通过从单核细胞诱导树突状细胞样分化来治疗或预防癌症以提高抗癌免疫活性的药物组合物公开(公告)号：US08614093B2
公开(公告)日：2013-12-24
申请号：US12934394
申请日：2009-03-24
申请人： Hiromi Kumon , Yasutomo Nasu , Masami Watanabe , Yuji Kashiwakura
发明人： Hiromi Kumon , Yasutomo Nasu , Masami Watanabe , Yuji Kashiwakura
CPC分类号： A61K38/18 , A61K38/00 , C07K14/4703 , C07K14/4747 , C12N5/0639 , C12N2501/22 , C12N2501/2304 , C12N2501/415
摘要： According to the present invention, a composition for inducing or activating dendritic cell-like cells so as to treat or prevent cancer by immunotherapy is provided.Specifically, the following is provided: an agent for activating cancer immunity, which comprises, as an active ingredient, the following REIC protein: (a) a protein consisting of the amino acid sequence shown in SEQ ID NO: 2; or (b) a protein consisting of an amino acid sequence derived from the amino acid sequence shown in SEQ ID NO: 2 by substitution, deletion, or addition of one or more amino acid(s) and having the activity of inducing differentiation from monocytes into dendritic cell-like cells.
摘要翻译： 根据本发明，提供了用于诱导或激活树突状细胞样细胞以通过免疫治疗来治疗或预防癌症的组合物。 具体而言，提供以下功能：用于激活癌症免疫的药剂，其包含作为活性成分的以下REIC蛋白质：（a）由SEQ ID NO：2所示的氨基酸序列组成的蛋白质; 或（b）通过取代，缺失或添加一个或多个氨基酸并且具有诱导从单核细胞分化的活性的由源自SEQ ID NO：2所示氨基酸序列的氨基酸序列组成的蛋白质 进入树突状细胞样细胞。
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5.发明授权Partial fragment of REIC/Dkk-3 gene and cancer therapeutic agent comprising the same 有权REIC / Dkk-3基因的部分片段和包含其的癌症治疗剂公开(公告)号：US08618273B2
公开(公告)日：2013-12-31
申请号：US12447044
申请日：2007-10-24
申请人： Hiromi Kumon , Nam-ho Huh , Masakiyo Sakaguchi , Yasutomo Nasu , Fernando Guillermo Abarzua Cabezas
发明人： Hiromi Kumon , Nam-ho Huh , Masakiyo Sakaguchi , Yasutomo Nasu , Fernando Guillermo Abarzua Cabezas
CPC分类号： C07K16/18 , A61K31/711 , A61K38/00 , A61K48/00 , C07K14/4747
摘要： This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding a polypeptide comprising an amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2; or (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence derived from the amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2 by substitution, deletion, or addition of 1 or several amino acids and having apoptosis activity.
摘要翻译： 本发明提供了包含REIC / Dkk-3基因的片段的癌细胞中的凋亡诱导剂和包含其的癌症治疗剂。 本发明还提供编码具有凋亡活性的多肽的编码REIC / Dkk-3蛋白（a）或（b）的多核苷酸片段：（a）编码包含氨基酸1的氨基酸序列的多肽的多核苷酸至任何 的如SEQ ID NO：2所示的REIC / Dkk-3蛋白的氨基酸序列的氨基酸39至78; 或（b）编码多肽的多核苷酸，其包含衍生自SEQ ID NO：1所示的REIC / Dkk-3蛋白的氨基酸序列的氨基酸1至氨基酸39至78的氨基酸序列的氨基酸序列的氨基酸序列 NO：2通过取代，缺失或添加1个或几个氨基酸并具有凋亡活性。
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6.发明申请PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER BY INDUCING DENDRITIC CELL-LIKE DIFFERENTIATION FROM MONOCYTES TO IMPROVE ANTICANCER IMMUNE ACTIVITY 有权通过诱导单核细胞中的细胞样细胞分化来治疗或预防癌症的药物组合物，以提高抗体免疫活性公开(公告)号：US20120034251A1
公开(公告)日：2012-02-09
申请号：US12934394
申请日：2009-03-24
申请人： Hiromi Kumon , Yasutomo Nasu , Masami Watanabe , Yuji Kashiwakura
发明人： Hiromi Kumon , Yasutomo Nasu , Masami Watanabe , Yuji Kashiwakura
IPC分类号： A61K38/17 , A61K31/711 , A61P37/04 , C12N15/861 , C12N5/0784 , A61P35/00 , C12N5/0786 , C12N15/85
CPC分类号： A61K38/18 , A61K38/00 , C07K14/4703 , C07K14/4747 , C12N5/0639 , C12N2501/22 , C12N2501/2304 , C12N2501/415
摘要： According to the present invention, a composition for inducing or activating dendritic cell-like cells so as to treat or prevent cancer by immunotherapy is provided.Specifically, the following is provided: an agent for activating cancer immunity, which comprises, as an active ingredient, the following REIC protein: (a) a protein consisting of the amino acid sequence shown in SEQ ID NO: 2; or (b) a protein consisting of an amino acid sequence derived from the amino acid sequence shown in SEQ ID NO: 2 by substitution, deletion, or addition of one or more amino acid(s) and having the activity of inducing differentiation from monocytes into dendritic cell-like cells.
摘要翻译： 根据本发明，提供了用于诱导或激活树突状细胞样细胞以通过免疫治疗来治疗或预防癌症的组合物。 具体而言，提供以下功能：用于激活癌症免疫的药剂，其包含作为活性成分的以下REIC蛋白质：（a）由SEQ ID NO：2所示的氨基酸序列组成的蛋白质; 或（b）通过取代，缺失或添加一个或多个氨基酸并且具有诱导从单核细胞分化的活性的由源自SEQ ID NO：2所示氨基酸序列的氨基酸序列组成的蛋白质 进入树突状细胞样细胞。
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7.发明授权公开(公告)号：US09493776B2
公开(公告)日：2016-11-15
申请号：US13510719
申请日：2010-11-19
申请人： Hiromi Kumon , Nam-Ho Huh , Masakiyo Sakaguchi , Masami Watanabe
发明人： Hiromi Kumon , Nam-Ho Huh , Masakiyo Sakaguchi , Masami Watanabe
CPC分类号： C12N15/67 , A61K38/1761 , C12N15/85 , C12N2799/025 , C12N2830/00 , C12N2830/50 , C12P21/02
摘要： An object of the present invention is to provide a method for increasing the expression of foreign genes, in particular, using a promoter, an enhancer, and the like, and an expression cassette containing a promoter, an enhancer, and the like, by which gene expression can be increased. The purpose is achieved with the use of the gene expression cassette comprising a DNA construct containing a gene to be expressed and a poly A addition sequence that are located downstream of a 1st promoter, and further comprising an enhancer or a 2nd promoter ligated downstream of the DNA construct.
摘要翻译： 本发明的目的是提供一种增加外源基因表达的方法，特别是使用启动子，增强子等，以及含有启动子，增强子等的表达盒，通过该方法， 可以增加基因表达。 该目的是通过使用包含含有待表达基因的DNA构建体和位于第一启动子下游的多聚A加成序列的基因表达盒来实现的，并且还包含连接在第一启动子下游的增强子或第二启动子 DNA构建体。
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公开(公告)号：US08658612B2
公开(公告)日：2014-02-25
申请号：US13056443
申请日：2009-07-30
申请人： Hiromi Kumon , Yasutomo Nasu , Yuji Kashiwakura , Masami Watanabe , Nam-ho Huh , Masakiyo Sakaguchi
发明人： Hiromi Kumon , Yasutomo Nasu , Yuji Kashiwakura , Masami Watanabe , Nam-ho Huh , Masakiyo Sakaguchi
CPC分类号： C07K14/47 , A61K35/13 , A61K38/00 , C12N2799/022
摘要： A method for potentiating the antitumor immunity in an animal by administering REIC/Dkk-3, or a therapeutic agent for malignant mesothelioma containing REIC/Dkk-3, or a vector containing the DNA as an active ingredient; wherein the DNA consists of the nucleotide sequence shown in SEQ ID NO: 1; or (b) a DNA hybridizing under stringent conditions to the DNA consisting of a nucleotide sequence complementary to the nucleotide sequence shown in SEQ ID NO: 1 and encoding a protein having apoptosis-inducing activity and interleukin (IL-7) production-accelerating activity in cells.
摘要翻译： 通过施用REIC / Dkk-3或含有REIC / Dkk-3的恶性间皮瘤的治疗剂或含有该DNA作为活性成分的载体来增强动物的抗肿瘤免疫力的方法。 其中DNA由SEQ ID NO：1所示的核苷酸序列组成; 或（b）在严格条件下与由与SEQ ID NO：1所示核苷酸序列互补的核苷酸序列组成的DNA杂交并编码具有凋亡诱导活性和白细胞介素（IL-7）产生加速活性的蛋白质的DNA 在细胞中。
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公开(公告)号：US20130267025A1
公开(公告)日：2013-10-10
申请号：US13807747
申请日：2011-07-01
申请人： Hiromi Kumon , Masami Watanabe , Junichiro Futami , Yasuyuki Fujii , Hideo Ueki , Kazuhiko Ochiai
发明人： Hiromi Kumon , Masami Watanabe , Junichiro Futami , Yasuyuki Fujii , Hideo Ueki , Kazuhiko Ochiai
IPC分类号： C07K14/47
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4703
摘要： A polypeptide capable of strongly inducing and activating dendritic-cell-like cells for treating or prevent cancer by immunotherapy, and DNA encoding the polypeptide. The polypeptide is a polypeptide (a) or (b) consisting of a partial region of the REIC/Dkk-3 protein.
摘要翻译： 能够强烈诱导和激活用于通过免疫治疗治疗或预防癌症的树突状细胞样细胞的多肽和编码该多肽的DNA。 多肽是由REIC / Dkk-3蛋白的部分区域组成的多肽（a）或（b）。
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10.发明申请公开(公告)号：US20120309050A1
公开(公告)日：2012-12-06
申请号：US13510719
申请日：2010-11-19
申请人： Hiromi Kumon , Nam-Ho Huh , Masakiyo Sakaguchi , Masami Watanabe
发明人： Hiromi Kumon , Nam-Ho Huh , Masakiyo Sakaguchi , Masami Watanabe
CPC分类号： C12N15/67 , A61K38/1761 , C12N15/85 , C12N2799/025 , C12N2830/00 , C12N2830/50 , C12P21/02
摘要： An object of the present invention is to provide a method for increasing the expression of foreign genes, in particular, using a promoter, an enhancer, and the like, and an expression cassette containing a promoter, an enhancer, and the like, by which gene expression can be increased. The purpose is achieved with the use of the gene expression cassette comprising a DNA construct containing a gene to be expressed and a poly A addition sequence that are located downstream of a 1st promoter, and further comprising an enhancer or a 2nd promoter ligated downstream of the DNA construct.
摘要翻译： 本发明的目的是提供一种增加外源基因表达的方法，特别是使用启动子，增强子等，以及含有启动子，增强子等的表达盒，通过该方法， 可以增加基因表达。 该目的是通过使用包含含有待表达基因的DNA构建体和位于第一启动子下游的多聚A加成序列的基因表达盒来实现的，并且还包含连接在第一启动子下游的增强子或第二启动子 DNA构建体。
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