公开(公告)号：US06861506B1

公开(公告)日：2005-03-01

申请号：US09534825

申请日：2000-03-23

申请人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed ,  Lynda E. Misher ,  Marc W. Retter ,  Davin C. Dillon

发明人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed ,  Lynda E. Misher ,  Marc W. Retter ,  Davin C. Dillon

IPC分类号： A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/15 ,  C07K14/47 ,  C07K14/82 ,  C12Q1/68 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K2/00

CPC分类号： C07K14/005 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00 ,  C12N2740/12022 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

摘要翻译： 公开了用于乳腺癌检测和治疗的组合物和方法。 所提供的化合物包括优先在乳腺肿瘤组织中表达的核苷酸序列，以及由该核苷酸序列编码的多肽。 还提供包含这些化合物的疫苗和药物组合物，并且可以用于例如乳腺癌的预防和治疗。 多肽也可用于生产抗体，其可用于诊断和监测患者乳腺癌的进展。

公开(公告)号：US06225054B1

公开(公告)日：2001-05-01

申请号：US08991789

申请日：1997-12-11

申请人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed

发明人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed

IPC分类号： C12Q168

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/82 ,  C12N2740/10022 ,  C12N2740/11022 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

摘要翻译： 公开了用于乳腺癌检测和治疗的组合物和方法。 所提供的化合物包括优先在乳腺肿瘤组织中表达的核苷酸序列，以及由该核苷酸序列编码的多肽。 还提供了包含这些化合物的疫苗和药物组合物，并且可以用于例如乳腺癌的预防和治疗。 多肽也可用于生产抗体，其可用于诊断和监测患者乳腺癌的进展。

公开(公告)号：US06344550B1

公开(公告)日：2002-02-05

申请号：US09062451

申请日：1998-04-17

申请人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed

发明人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed

IPC分类号： C07H2104

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/82 ,  C12N2740/10022 ,  C12N2740/11022 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

摘要翻译： 公开了用于乳腺癌检测和治疗的组合物和方法。 所提供的化合物包括优先在乳腺肿瘤组织中表达的核苷酸序列，以及由该核苷酸序列编码的多肽。 还提供了包含这些化合物的疫苗和药物组合物，并且可以用于例如乳腺癌的预防和治疗。 多肽也可用于生产抗体，其可用于诊断和监测患者乳腺癌的进展。

公开(公告)号：US06586570B1

公开(公告)日：2003-07-01

申请号：US09289198

申请日：1999-04-09

申请人： Tony N. Frudakis ,  Steven G. Reed ,  John M. Smith ,  Lynda Misher

发明人： Tony N. Frudakis ,  Steven G. Reed ,  John M. Smith ,  Lynda Misher

IPC分类号： C07K1400

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/82 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

公开(公告)号：US06423496B1

公开(公告)日：2002-07-23

申请号：US09598326

申请日：2000-06-20

申请人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed

发明人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed

IPC分类号： C12Q168

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/82 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

公开(公告)号：US07241876B2

公开(公告)日：2007-07-10

申请号：US09924400

申请日：2001-08-07

申请人： Tony N. Frudakis ,  Steven G. Reed ,  John M. Smith ,  Lynda E. Misher ,  Davin C. Dillon ,  Marc W. Retter ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Susan L. Harlocker ,  Craig H. Day ,  Samuel X. Li ,  Ta Deng

发明人： Tony N. Frudakis ,  Steven G. Reed ,  John M. Smith ,  Lynda E. Misher ,  Davin C. Dillon ,  Marc W. Retter ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Susan L. Harlocker ,  Craig H. Day ,  Samuel X. Li ,  Ta Deng

IPC分类号： C07H21/02

CPC分类号： C12Q1/6886 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00 ,  C12N2740/14022 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

公开(公告)号：US06828431B1

公开(公告)日：2004-12-07

申请号：US09699295

申请日：2000-10-26

申请人： Tony N. Frudakis ,  Steven G. Reed ,  John M. Smith ,  Lynda E. Misher ,  Davin C. Dillon ,  Marc W. Retter ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Susan L. Harlocker

发明人： Tony N. Frudakis ,  Steven G. Reed ,  John M. Smith ,  Lynda E. Misher ,  Davin C. Dillon ,  Marc W. Retter ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Susan L. Harlocker

IPC分类号： C12Q170

CPC分类号： C07K14/005 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00 ,  C12N2740/11022 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S436/813

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

公开(公告)号：US06228372B1

公开(公告)日：2001-05-08

申请号：US08993674

申请日：1997-12-18

申请人： Steven G. Reed ,  Yasir A. W. Skeiky ,  Michael J. Lodes ,  Raymond L. Houghton ,  John M. Smith ,  Patricia D. McNeill

发明人： Steven G. Reed ,  Yasir A. W. Skeiky ,  Michael J. Lodes ,  Raymond L. Houghton ,  John M. Smith ,  Patricia D. McNeill

IPC分类号： A61K39002

CPC分类号： G01N33/56905 ,  A61K38/00 ,  A61K39/00 ,  C07K14/44 ,  G01N2333/44 ,  Y02A50/414

摘要： Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.

摘要翻译： 提供化合物和方法用于诊断克氏锥虫感染。 所公开的化合物是含有一个或多个克氏锥虫抗原表位的多肽或其抗体。 该化合物可用于各种用于检测克氏锥虫感染的免疫测定。 多肽化合物还可用于疫苗和药物组合物，用于在暴露于克氏锥虫的个体中诱导针对恰加斯氏病的保护性免疫。

公开(公告)号：US06419933B1

公开(公告)日：2002-07-16

申请号：US09256976

申请日：1999-02-24

申请人： Steven G. Reed ,  Yasir A. W. Skeiky ,  Michael J. Lodes ,  Raymond L. Houghton ,  John M. Smith ,  Patricia D. McNeill

发明人： Steven G. Reed ,  Yasir A. W. Skeiky ,  Michael J. Lodes ,  Raymond L. Houghton ,  John M. Smith ,  Patricia D. McNeill

IPC分类号： A61K39002

CPC分类号： G01N33/56905 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/44 ,  G01N2333/44 ,  Y02A50/414

摘要： Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.

摘要翻译： 提供化合物和方法用于诊断克氏锥虫感染。 所公开的化合物是含有一个或多个克氏锥虫抗原表位的多肽或其抗体。 该化合物可用于各种用于检测克氏锥虫感染的免疫测定。 多肽化合物还可用于疫苗和药物组合物，用于在暴露于克氏锥虫的个体中诱导针对恰加斯氏病的保护性免疫。

公开(公告)号：US08865180B2

公开(公告)日：2014-10-21

申请号：US12901961

申请日：2010-10-11

申请人： Yasuyuki Goto ,  Steven G. Reed

发明人： Yasuyuki Goto ,  Steven G. Reed

IPC分类号： A61K39/00 ,  A61K39/02 ,  G01N33/50 ,  G01N33/569 ,  G01N33/68

CPC分类号： G01N33/56905 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091 ,  G01N33/6854 ,  G01N2500/00

摘要： Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.

摘要翻译： 提供了用于诊断，预防，治疗和检测利什曼病感染和刺激患者免疫应答的化合物和方法。 所公开的化合物包括含有一种或多种利什曼原虫抗原或其变体的至少一种免疫原性部分的多肽和融合蛋白。 另外，公开了筛选具有免疫原性的串联重复蛋白的筛选文库的方法。 描述了可用于预防和治疗利什曼病以及利什曼病感染检测的包含多核苷酸，多肽，融合蛋白及其变体的疫苗和药物组合物。