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1.发明申请INHIBITORS OF JANUS KINASES AND/OR 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 有权甘薯和/或3-磷酸腺苷依赖性蛋白激酶-1的抑制剂公开(公告)号：US20100160309A1
公开(公告)日：2010-06-24
申请号：US12530648
申请日：2008-03-10
申请人： Tony Siu , Jonathan Young , Micheal Altman , Alan Northrup , Ekaterina Kozina , Christopher Dinsmore , David J. Guerin , Kevin A. Keenan , Joon O. Jung , Solomon Kattar , Rachel N. MacCoss
发明人： Tony Siu , Jonathan Young , Micheal Altman , Alan Northrup , Ekaterina Kozina , Christopher Dinsmore , David J. Guerin , Kevin A. Keenan , Joon O. Jung , Solomon Kattar , Rachel N. MacCoss
IPC分类号： A61K31/4375 , C07D471/04 , C07D471/14 , A61P35/00 , A61K31/5377 , A61K31/501 , A61K31/506
CPC分类号： C07D471/04 , C07D471/14
摘要： The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound to a patient in need of treatment or prevention of myeloproliferative disorders or cancer.
摘要翻译： 本发明提供抑制JAK2酪氨酸激酶和/或PDK1的化合物。 本发明还提供了包含这种抑制化合物的组合物以及通过将该化合物给予需要治疗或预防骨髓增生性疾病或癌症的患者来抑制JAK2酪氨酸激酶活性和/或PDK1激酶抑制活性的方法。
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2.发明授权Inhibitors of janus kinases and/or 3-phosphoinositide-dependent protein kinase-1 有权甘油激酶和/或3-磷酸肌醇依赖性蛋白激酶-1的抑制剂公开(公告)号：US08329722B2
公开(公告)日：2012-12-11
申请号：US12530648
申请日：2008-03-10
申请人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Ekaterina Kozina , Christopher Dinsmore , David J. Guerin , Kevin A. Keenan , Joon O. Jung , Solomon Kattar , Rachel N. MacCoss
发明人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Ekaterina Kozina , Christopher Dinsmore , David J. Guerin , Kevin A. Keenan , Joon O. Jung , Solomon Kattar , Rachel N. MacCoss
IPC分类号： C07D487/14 , A61K31/4375
CPC分类号： C07D471/04 , C07D471/14
摘要： The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound to a patient in need of treatment or prevention of myeloproliferative disorders or cancer.
摘要翻译： 本发明提供抑制JAK2酪氨酸激酶和/或PDK1的化合物。 本发明还提供了包含这种抑制化合物的组合物以及通过将该化合物给予需要治疗或预防骨髓增生性疾病或癌症的患者来抑制JAK2酪氨酸激酶活性和/或PDK1激酶抑制活性的方法。
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![PYRAZOLO [3,4-B] PYRIDIN-4-ONE KINASE INHIBITORS](/abs-image/US/2012/08/30/US20120220624A1/abs.jpg.150x150.jpg)
公开(公告)号：US20120220624A1
公开(公告)日：2012-08-30
申请号：US13497660
申请日：2010-09-29
IPC分类号： A61K31/437 , A61P25/28 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention is directed to novel kinase inhibitors of general formula (I) and pharmaceutically acceptable salts thereof, and to the use of the kinase inhibitors of general formula (I) for treating diseases or disorders in which tau phosphorylation and cell cycle regulation is implicated, such as Alzheimer's Disease and cancer.
摘要翻译： 本发明涉及通式（I）的新型激酶抑制剂及其药学上可接受的盐，以及通式（I）的激酶抑制剂用于治疗其中涉及tau磷酸化和细胞周期调节的疾病或病症的用途 ，如阿尔茨海默病和癌症。
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公开(公告)号：US08962608B2
公开(公告)日：2015-02-24
申请号：US14345976
申请日：2012-09-21
申请人： Jason Brubaker , Christopher Dinsmore , Dawn Marie Hoffman , Joon Jung , Duan Liu , Scott Peterson , Tony Siu , Luis E. Torres , Hongjun Zhang , Zhongyong Wei , Feng Shi
发明人： Jason Brubaker , Christopher Dinsmore , Dawn Marie Hoffman , Joon Jung , Duan Liu , Scott Peterson , Tony Siu , Luis E. Torres , Hongjun Zhang , Zhongyong Wei , Feng Shi
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/415 , C07D231/38 , C07D403/08 , C07D403/12 , C07D405/08 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译： 本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。
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公开(公告)号：US20060293358A1
公开(公告)日：2006-12-28
申请号：US11473273
申请日：2006-06-22
申请人： Christopher Dinsmore , Ana Gabarda Ortega , David Guerin , James Jewell , Jason Katz , Jongwon Lim , Michelle Machacek , Ryan Otte , Jonathan Young
发明人： Christopher Dinsmore , Ana Gabarda Ortega , David Guerin , James Jewell , Jason Katz , Jongwon Lim , Michelle Machacek , Ryan Otte , Jonathan Young
IPC分类号： A61K31/473 , C07D221/02
CPC分类号： C07D471/04 , C07D221/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D491/10 , C07D491/113 , C07F7/1804
摘要： The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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公开(公告)号：US20070054892A1
公开(公告)日：2007-03-08
申请号：US10572236
申请日：2004-09-22
申请人： Richard Isaacs , Christopher Dinsmore , B. Trotter , Nigel Liverton , Douglas Beshore , Nathan Kett , Charles McIntyre , Kausik Nanda , David Claremon
发明人： Richard Isaacs , Christopher Dinsmore , B. Trotter , Nigel Liverton , Douglas Beshore , Nathan Kett , Charles McIntyre , Kausik Nanda , David Claremon
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4709 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C04B35/632 , C07D217/22 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/04
摘要： The present invention relates to compounds of structural formula I: I useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及结构式I的化合物：可用作治疗心律失常的钾通道抑制剂等。
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公开(公告)号：US20060030595A1
公开(公告)日：2006-02-09
申请号：US11188466
申请日：2005-07-25
申请人： Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
发明人： Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
IPC分类号： A61K31/506 , A61K31/444 , C07D401/14 , C07D403/14
CPC分类号： C07D213/57 , C07D213/06 , C07D213/30 , C07D213/42 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
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公开(公告)号：US20070043042A1
公开(公告)日：2007-02-22
申请号：US10571841
申请日：2004-09-17
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4709 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D215/48 , C07D401/02 , C07D401/04 , C07D401/12 , C07D403/02 , C07D413/02 , C07D413/12 , C07D413/14
摘要： The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构（I）的化合物等。
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公开(公告)号：US20060128783A1
公开(公告)日：2006-06-15
申请号：US10523286
申请日：2003-08-05
IPC分类号： A61K31/404 , C07D403/02 , C07D209/36
CPC分类号： C07D403/12 , C07D209/42 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises an indole-sulfonamide moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
摘要翻译： 本发明涉及能够抑制，调节和/或调节受体型和非受体型酪氨酸激酶的信号转导的化合物。 本发明的化合物具有包含吲哚磺酰胺部分的核心结构。 本发明还涉及这些化合物的药学上可接受的盐，水合物和立体异构体。
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公开(公告)号：US5780488A
公开(公告)日：1998-07-14
申请号：US824588
申请日：1997-03-26
IPC分类号： C07D213/53 , C07D233/22 , C07D233/24 , C07D233/54 , A61K31/415 , A61K31/44 , C07D213/02
CPC分类号： C07D213/53 , C07D233/22 , C07D233/24
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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