公开(公告)号：US4086417A

公开(公告)日：1978-04-25

申请号：US622794

申请日：1975-10-15

申请人： Torao Ishida ,  Minoru Akiyama ,  Yoshio Sakurai ,  Shigeru Tsukagoshi

发明人： Torao Ishida ,  Minoru Akiyama ,  Yoshio Sakurai ,  Shigeru Tsukagoshi

IPC分类号： C07H19/10

CPC分类号： C07H19/10

摘要： A nucleotide derivative represented by the general formula: ##STR1## wherein R represents an acyl group having 14 - 22 carbon atoms and having an aliphatic acyl moiety; X represents a hydrogen atom, a halogen atom, an alkyl group having 1 - 4 carbon atoms, or a trifluoromethyl group; and at least one, but not all, of Y.sub.1, Y.sub.2, and Y.sub.3 represents a phosphate, a pyrophosphate, a triphosphate, or a salt thereof, the balance of Y.sub.1, Y.sub.2 and Y.sub.3 representing a hydroxyl group; or in case of ribosyl, Y.sub.1 and Y.sub.3, or Y.sub.2 and Y.sub.3 represent, at the same time, the aforesaid phosphate, pyrophosphate, triphosphate or salt thereof and the remaining group of Y.sub.1, Y.sub.2 or Y.sub.3 represents a hydroxyl group; or in case of arabinosyl, Y.sub.1 and Y.sub.2, or Y.sub.2 and Y.sub.3 represent, at the same time, the aforesaid phosphate, pyrophosphate, triphosphate or salt therof and the remaining group of Y.sub.1, Y.sub.2 or Y.sub.3 represents a hydroxyl group. The nontoxic salts of these phosphates are useful as an antileukemialagent for mice which is soluble in water and has high stability.

摘要翻译： 由以下通式表示的核苷酸衍生物：其中R表示具有14-22个碳原子且具有脂族酰基部分的酰基; X表示氢原子，卤素原子，具有1-4个碳原子的烷基或三氟甲基; Y1，Y2和Y3中的至少一个但不是全部表示磷酸酯，焦磷酸酯，三磷酸酯或其盐，余量的Y1，Y2和Y3表示羟基; 或在核糖基，Y1和Y3的情况下，或Y2和Y3同时表示上述磷酸盐，焦磷酸盐，三磷酸盐或其盐，剩余的Y 1，Y 2或Y 3基团表示羟基; 或在阿糖基，Y1和Y2的情况下，或Y2和Y3同时表示上述磷酸盐，焦磷酸盐，三磷酸盐或盐，而剩余的Y1，Y2或Y3基团表示羟基。 这些磷酸盐的无毒盐可用作可溶于水并具有高稳定性的小鼠的抗白血病细胞。

公开(公告)号：US4097665A

公开(公告)日：1978-06-27

申请号：US634706

申请日：1975-11-24

申请人： Torao Ishida ,  Minoru Akiyama ,  Daikichi Nishimura ,  Hiroshi Hayashi ,  Yoshio Sakurai ,  Shigeru Tsukagoshi

发明人： Torao Ishida ,  Minoru Akiyama ,  Daikichi Nishimura ,  Hiroshi Hayashi ,  Yoshio Sakurai ,  Shigeru Tsukagoshi

IPC分类号： C07H19/09 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7076 ,  A61P35/02 ,  C07H19/06 ,  C07H19/20 ,  C07H19/08

CPC分类号： C07H19/06 ,  Y02P20/55 ,  Y10S514/908

摘要： Compounds represented by formula (I) ##STR1## wherein one of Z.sub.1 ', Z.sub.2 ', Z.sub.3 ' and Z.sub.4 ' represents R, another one of Z.sub.1 ', Z.sub.2 ', Z.sub.3 ' and Z.sub.4 ' represents Z, and the remaining two moieties of Z.sub.1 ', Z.sub.2 ', Z.sub.3 ' and Z.sub.4 ' represents a hydrogen atom and/or a protective group, one of R and Z represents A.sub.1 and the other represents A.sub.2, A.sub.1 being an acyl group having 14 to 22 carbon atoms which does not contain a carboxylic group and A.sub.2 being an acyl group having 2 to 14 carbon atoms and having one carboxyl group, X represents a hydrogen atom or a halogen atom (hereinafter referred to as Compound Ia); a 2,2'-anhydro product of Compound Ia wherein Z.sub.2 ' represents a hydrogen atom (hereinafter referred to as Compound Ib); an arabinosylation product of Compound Ia (hereinafter referred to as Compound Ic); a deamination product of Compound Ia (hereinafter referred to as Compound Id); a 2'-deoxy product of Compound Id wherein Z.sub.2 ' represents a hydrogen atom (hereinafter referred to as Compound Ie); a salt of Compound Ia, Ib, Ic, or Id or Ie having an A.sub.2 group with a base (hereinafter referred to as Compound If); and a salt of Compound Ia, Ib or Ic wherein Z.sub.1 ' represents a hydrogen atom with an acid (hereinafter referred to as Compound Ih); and processes for preparing the same.

摘要翻译： 由式（I）表示的化合物其中Z1'，Z2'，Z3'和Z4'之一表示R，Z1'，Z2'，Z3'和Z4'中的另一个表示Z，剩余的 Z1'，Z2'，Z3'和Z4'的两个部分表示氢原子和/或保护基，R和Z之一表示A1，另一个表示A2，A1表示具有14-22个碳原子的酰基， 不含羧基，A2为碳原子数2〜14的酰基，具有1个羧基，X表示氢原子或卤素原子（以下称为化合物Ia）。 化合物Ia的2,2'-脱水产物，其中Z2'表示氢原子（以下称为化合物Ib）; 化合物Ia的阿拉伯糖基化产物（以下称为化合物Ic）; 化合物Ia的脱氨产物（以下称为化合物Id）; 化合物Id的2'-脱氧产物，其中Z2'表示氢原子（以下称为化合物Ie）; 具有A2基团的化合物Ia，Ib，Ic或Id或Ie的盐（以下称为化合物If）; 和化合物Ia，Ib或Ic的盐，其中Z1'表示氢原子与酸（以下称为化合物Ih）; 及其制备方法。

公开(公告)号：US3991045A

公开(公告)日：1976-11-09

申请号：US540294

申请日：1975-01-10

申请人： Torao Ishida ,  Kageyasu Akashi ,  Koichi Yoshida ,  Minoru Akiyama ,  Yoshio Sakurai ,  Shigeru Tsukagoshi

发明人： Torao Ishida ,  Kageyasu Akashi ,  Koichi Yoshida ,  Minoru Akiyama ,  Yoshio Sakurai ,  Shigeru Tsukagoshi

IPC分类号： C07H19/06

CPC分类号： C07H19/06

摘要： An N.sup.4 -acyl-1-.beta.-D-arabinofuranosylcytosine having the following formula ##SPC1##Wherein R is an aliphatic acyl group having 3 to 35 carbon atoms. The compounds of this invention are useful as a cancer chemotherapeutic agent for controlling tumors, e.g., in mice, an insecticide, and a fungicidal surface active agent.

摘要翻译： 具有下式的N 4 - 酰基-1-β-D-阿拉伯呋喃糖基胞嘧啶R是具有3至35个碳原子的脂族酰基。 本发明的化合物可用作控制肿瘤的癌症化学治疗剂，例如在小鼠，杀虫剂和杀真菌剂表面活性剂中。

公开(公告)号：US4055716A

公开(公告)日：1977-10-25

申请号：US675050

申请日：1976-04-08

申请人： Torao Ishida ,  Takashi Shirai ,  Minoru Akiyama

发明人： Torao Ishida ,  Takashi Shirai ,  Minoru Akiyama

IPC分类号： C07H19/06

CPC分类号： C07H19/06 ,  Y10S514/908

摘要： N.sup.4 -Acyl-1-.beta.-D-arabinofuranosylcytosine-5'-esters represented by the formula ##STR1## wherein R.sup.1 represents an acyl group having 3 to 28 carbon atoms and R.sup.2 represents an XCH.sub.2, XCH.sub.2 CH.sub.2 or CH.sub.3 CHX group, wherein X represents a halogen atom, a (CH.sub.3).sub.2 N or (C.sub.2 H.sub.5).sub.2 N group.

摘要翻译： 由式“IMAGE”表示的N4-酰基-β-D-阿拉伯呋喃糖基胞嘧啶-5'-酯，其中R1表示具有3至28个碳原子的酰基，R2表示XCH2，XCH2CH2或CH3CHX基团，其中X表示 卤素原子，（CH 3）2 N或（C 2 H 5）2 N基团。

公开(公告)号：US20060168482A1

公开(公告)日：2006-07-27

申请号：US11338626

申请日：2006-01-25

申请人： Minoru Akiyama

发明人： Minoru Akiyama

IPC分类号： G06F11/00

CPC分类号： G11B20/1883 ,  G11B2220/20

摘要： To specify defect management information to be used in a short time in an information recording medium having a defect information area capable of recording plural sets of defect management information and a selection information area capable of recording plural sets of selection information for selecting a set of defect management information from the defect information area. The selection information includes information about a position where the latest management information at the time of writing is written, and history information indicating that the selection information is updated.

摘要翻译： 在具有能够记录多组缺陷管理信息的缺陷信息区域的信息记录介质中指定要在短时间内使用的缺陷管理信息，以及能够记录用于选择缺陷集合的多组选择信息的选择信息区域 来自缺陷信息区的管理信息。 选择信息包括关于写入写入时的最新管理信息的位置以及表示选择信息被更新的历史信息的信息。

公开(公告)号：US5030842A

公开(公告)日：1991-07-09

申请号：US540893

申请日：1990-06-20

申请人： Masao Koshinaka ,  Minoru Akiyama ,  Toshimasa Tomoda

发明人： Masao Koshinaka ,  Minoru Akiyama ,  Toshimasa Tomoda

IPC分类号： G01N21/88 ,  G01N15/02 ,  G01N15/14 ,  G01N21/21 ,  G01N21/47 ,  G01N21/94 ,  G01N21/95 ,  G01N21/956 ,  H01L21/66

CPC分类号： G01N15/0205 ,  G01N21/94 ,  G01N2015/145 ,  G01N21/21 ,  G01N21/47 ,  G01N21/9501

摘要： A fine-particle measuring apparatus designed to measure fine particles attached to the surface of a substrate of a semiconductor device set in a processing unit for formation of films, etching, cleaning, etc. and fine particles suspended in the space above the substrate surface by the use of scattering of a laser beam caused by these fine particles. The measuring apparatus comprises a laser light phase modulator for generating two laser beams which have the same wavelength and the phase difference between which is modulated at a predetermined frequency, an optical system which causes the two laser beams to intersect each other within a space containing the fine particles being the objects of measurement, a photodetector which receives light scattered by any of the fine particles in the region which the two laser beams intersect, and converts the received light into an electrical signal, and a signal processor which extracts from the electrical signal based on the scattered light of a signal component whose frequency is the same as or double that of a phase modulating signal for the modulation effected in the laser beam phase modulator and which has a constant phase difference with respect to the phase modulating signal. Thus, it is possible to measure fine particles with high spatial resolving power without substantially disturbing the environment inside the process unit or the process itself.

摘要翻译： 一种微粒测量装置，设计用于测量附着在半导体器件的基板的表面上的细颗粒，该半导体器件的基板的表面设置在用于形成膜，蚀刻，清洁等的处理单元中，以及悬浮在基板表面上方的空间中的细颗粒 使用由这些细颗粒引起的激光束的散射。 测量装置包括激光相位调制器，用于产生具有相同波长的两个激光束，并且其相位差以预定频率被调制;使得两个激光束在包含该两个激光束的空间内彼此相交的光学系统 作为测量对象的微粒子，接收由两个激光束相交的区域中的任何细颗粒散射的光并将接收的光转换为电信号的光检测器，以及从电信号中提取的信号处理器 基于在激光束相位调制器中进行的调制的相位调制信号的频率相同或相反的信号分量的散射光，并且相对于相位调制信号具有恒定的相位差。 因此，可以测量具有高空间分辨能力的细颗粒，而基本上不会干扰处理单元内的环境或过程本身。

公开(公告)号：US07057776B2

公开(公告)日：2006-06-06

申请号：US09793265

申请日：2001-02-26

申请人： Minoru Akiyama

发明人： Minoru Akiyama

IPC分类号： H04N1/04 ,  H04N1/40

CPC分类号： H04N1/58 ,  G06K15/02 ,  G06K15/1852 ,  G06K2215/0065 ,  H04N1/46

摘要： To improve a sharpness and quality of images. An image processing apparatus includes: a drawing process unit for analyzing drawing information in print data; a color spatial conversion unit for transforming color information; a smoothing correction unit for outline-correcting the print data; a gradation processing unit for processing a gradation of the print data; and an output unit for performing a predetermined process based on text image data output from the smoothing correction unit and image data output from the gradation processing unit to output print image information to the outside, and the color spatial conversion unit separately sets intensity values, and the output unit outputs the text image data provided from the smoothing correction unit by priority over a text image data provided from the gray scale processing unit, according to an analysis of drawing information.

摘要翻译： 提高图像的清晰度和质量。 图像处理装置包括：绘图处理单元，用于分析打印数据中的绘图信息; 颜色空间转换单元，用于变换颜色信息; 平滑校正单元，用于轮廓校正打印数据; 灰度处理单元，用于处理打印数据的灰度; 以及输出单元，用于基于从平滑校正单元输出的文本图像数据和从灰度处理单元输出的图像数据来执行预定处理，以将打印图像信息输出到外部，并且颜色空间转换单元分别设置强度值，以及 输出单元根据绘图信息的分析，从由灰度处理单元提供的文本图像数据优先地输出从平滑校正单元提供的文本图像数据。

公开(公告)号：US06707575B1

公开(公告)日：2004-03-16

申请号：US09435636

申请日：1999-11-08

申请人： Minoru Akiyama

发明人： Minoru Akiyama

IPC分类号： G06R1500

CPC分类号： G06K15/1223

摘要： A resolution heightening circuit comprises a modulation information generating circuit that receives printing data supplied from a host printer control circuit to generate a pulse width modulation information signal on the basis of the printing data. The modulation information generating circuit uses a reference template of four lines by three dots to increase the number of dots for a line at a printing unit. A modulation circuit is connected to the modulation information generating circuit and the printing unit and produces modulated driving pulses in response to the pulse width modulation information signal to supply the modulated driving pulses to the printing unit.

摘要翻译： 分辨率提高电路包括调制信息产生电路，其接收从主机打印机控制电路提供的打印数据，以根据打印数据生成脉宽调制信息信号。 调制信息生成电路使用四行×三点的基准模板来增加印刷单元中的线的点数。 调制电路连接到调制信息产生电路和打印单元，并且响应于脉宽调制信息信号产生调制的驱动脉冲，以将调制的驱动脉冲提供给打印单元。

公开(公告)号：US5764092A

公开(公告)日：1998-06-09

申请号：US650635

申请日：1996-05-20

申请人： Koji Wada ,  Minoru Akiyama

发明人： Koji Wada ,  Minoru Akiyama

IPC分类号： H03K5/135 ,  G06F1/06 ,  H03K5/15 ,  H03L7/081 ,  H03H11/26

CPC分类号： H03L7/0814

摘要： The present invention provides a delay clock generator where a plurality of stable delay clocks can be generated and digitizing is easy. The delay clock generator comprises first to nth (n: integer not less than 2) delay circuits (11 to 1n) connected in cascade connection for delaying the basic clock (KO) in sequence, a phase comparator (21) for comparing phase of a delay clock from the nth delay circuit (1n) with that of the basic clock, and a delay control circuit (31) for generating a delay control value to make the phase of the delay clock from the nth delay circuit synchronize with that of the basic clock based on a phase comparison result, and for controlling delay amounts of the first to nth delay circuits respectively by the delay control value. In the present invention, a voltage control type oscillator is not used, and since delay amounts of the first to nth delay circuits are controlled by the delay control value generated based on the phase comparison result, the delay clock generator can be constituted wholly by digital circuits and moreover can generate stable delay clocks.

摘要翻译： 本发明提供一种延迟时钟发生器，其中可以产生多个稳定的延迟时钟并且数字化容易。 所述延迟时钟发生器包括以级联方式连接的用于延迟基本时钟（KO）的第一至第n（n：整数不小于2）的延迟电路（11至1n），用于比较相位 从第n延迟电路（1n）延迟时钟与基本时钟的延迟时钟;以及延迟控制电路（31），用于产生延迟控制值以使来自第n个延迟电路的延迟时钟的相位与基本时钟同步 基于相位比较结果的时钟，并且分别控制延迟控制值的第一至第N延迟电路的延迟量。 在本发明中，不使用电压控制型振荡器，由于第1〜第n延迟电路的延迟量由基于相位比较结果而产生的延迟控制值进行控制，所以延迟时钟发生器可以完全由数字 电路，而且可以产生稳定的延迟时钟。

公开(公告)号：US07831880B2

公开(公告)日：2010-11-09

申请号：US11338626

申请日：2006-01-25

申请人： Minoru Akiyama

发明人： Minoru Akiyama

IPC分类号： H03M13/00

CPC分类号： G11B20/1883 ,  G11B2220/20

摘要： To specify defect management information to be used in a short time in an information recording medium having a defect information area capable of recording plural sets of defect management information and a selection information area capable of recording plural sets of selection information for selecting a set of defect management information from the defect information area. The selection information includes information about a position where the latest management information at the time of writing is written, and history information indicating that the selection information is updated.

摘要翻译： 在具有能够记录多组缺陷管理信息的缺陷信息区域的信息记录介质中指定要在短时间内使用的缺陷管理信息，以及能够记录用于选择缺陷集合的多组选择信息的选择信息区域 来自缺陷信息区的管理信息。 选择信息包括关于写入写入时的最新管理信息的位置以及表示选择信息被更新的历史信息的信息。