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公开(公告)号：US07501395B2
公开(公告)日：2009-03-10
申请号：US11380035
申请日：2006-04-25
申请人： Toru Sawai , Michiyuki Suzuki , Carsten Beuckmann , Kodo Shikata
发明人： Toru Sawai , Michiyuki Suzuki , Carsten Beuckmann , Kodo Shikata
CPC分类号： G01N33/948 , G01N33/5088 , G01N2800/301
摘要： An anxiolytic drug of the invention comprises an orexin receptor antagonist, a pharmacologically acceptable salt thereof, or a solvate thereof as an active ingredient. A method for screening a compound having an anxiolytic action of the invention comprises a step of using orexin-A.
摘要翻译： 本发明的抗焦虑药物包含食欲肽受体拮抗剂，其药理学上可接受的盐或其溶剂化物作为活性成分。 筛选具有本发明抗焦虑作用的化合物的方法包括使用食欲肽A的步骤。
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公开(公告)号：US20070160538A1
公开(公告)日：2007-07-12
申请号：US11380035
申请日：2006-04-25
申请人： Toru Sawai , Michiyuki Suzuki , Carsten Beuckmann , Kodo Shikata
发明人： Toru Sawai , Michiyuki Suzuki , Carsten Beuckmann , Kodo Shikata
CPC分类号： G01N33/948 , G01N33/5088 , G01N2800/301
摘要： An anxiolytic drug of the invention comprises an orexin receptor antagonist, a pharmacologically acceptable salt thereof, or a solvate thereof as an active ingredient. A method for screening a compound having an anxiolytic action of the invention comprises a step of using orexin-A.
摘要翻译： 本发明的抗焦虑药物包含食欲肽受体拮抗剂，其药理学上可接受的盐或其溶剂化物作为活性成分。 筛选具有本发明抗焦虑作用的化合物的方法包括使用食欲肽A的步骤。
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公开(公告)号：US08268848B2
公开(公告)日：2012-09-18
申请号：US13237205
申请日：2011-09-20
申请人： Taro Terauchi , Ayumi Takemura , Takashi Doko , Yu Yoshida , Toshiaki Tanaka , Keiichi Sorimachi , Yoshimitsu Naoe , Carsten Beuckmann , Yuji Kazuta
发明人： Taro Terauchi , Ayumi Takemura , Takashi Doko , Yu Yoshida , Toshiaki Tanaka , Keiichi Sorimachi , Yoshimitsu Naoe , Carsten Beuckmann , Yuji Kazuta
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D401/12 , C07D239/34
摘要： A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents —CH— or a nitrogen atom, R1a and R1b each independently represent a C1-6 alkyl group and the like, R1c represents a hydrogen atom and the like, R2a, R2b, R2c and R2d each independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group and the like, R3a, R3b and R3c each independently represent a hydrogen atom, a halogen atom and the like, and R3d represents a hydrogen atom and the like.
摘要翻译： 由下式（A）表示的环丙烷化合物或其药学上可接受的盐具有食欲肽受体拮抗作用，因此具有治疗食欲肽受体拮抗作用有效的睡眠障碍的潜在用途，例如失眠症：其中Q表示 -CH-或氮原子，R1a和R1b各自独立地表示C1-6烷基等，R1c表示氢原子等，R2a，R2b，R2c和R2d各自独立地表示氢原子，卤素原子 C 1-6烷基等，R 3a，R 3b和R 3c各自独立地表示氢原子，卤素原子等，R 3d表示氢原子等。
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公开(公告)号：US20120165339A1
公开(公告)日：2012-06-28
申请号：US13330972
申请日：2011-12-20
申请人： Taro Terauchi , Ayumi Takemura , Yuji Kazuta , Fumihiro Ozaki , Takashi Doko , Yu Yoshida , Toshiaki Tanaka , Keiichi Sorimachi , Yoshimitsu Naoe , Carsten Beuckmann
发明人： Taro Terauchi , Ayumi Takemura , Yuji Kazuta , Fumihiro Ozaki , Takashi Doko , Yu Yoshida , Toshiaki Tanaka , Keiichi Sorimachi , Yoshimitsu Naoe , Carsten Beuckmann
IPC分类号： A61K31/501 , A61K31/444 , A61K31/443 , A61K31/4439 , A61K31/44 , A61K31/4196 , A61K31/427 , A61K31/428 , A61K31/42 , A61K31/4184 , A61K31/415 , A61K31/165 , C07D237/16 , C07D413/12 , C07D401/12 , C07D405/12 , C07D213/75 , C07D285/08 , C07D417/12 , C07D275/03 , C07D261/14 , C07D249/08 , C07D231/56 , C07D231/18 , C07C233/60 , A61P25/20 , A61K31/50
CPC分类号： C07D231/20 , C07C235/40 , C07D213/55 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/75 , C07D231/12 , C07D233/60 , C07D235/12 , C07D237/16 , C07D237/20 , C07D239/42 , C07D241/18 , C07D253/065 , C07D261/14 , C07D261/20 , C07D271/10 , C07D275/03 , C07D277/24 , C07D277/36 , C07D277/46 , C07D285/08 , C07D285/135 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： A cyclopropane derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof has orexin receptor inhibitory action, and thus, is extremely useful as an agent for preventing or treating sleep disorder or dyssomnia caused by orexin, including insomnia as a typical example: wherein A1, A2 and A3 each independently represent an aryl group, a heterocyclyl group or the like, R1, R2 and R3 each independently represent a hydrogen atom, a C1-6 alkyl group or the like, X represents an oxygen atom or the like, and L represents a bond or the like.
摘要翻译： 由下式（I）表示的环丙烷衍生物或其药学上可接受的盐具有食欲素受体抑制作用，因此作为典型的例子，包括失眠引起的睡眠障碍或睡眠障碍引起的睡眠障碍或睡眠不适， ：其中A1，A2和A3各自独立地表示芳基，杂环基等，R1，R2和R3各自独立地表示氢原子，C1-6烷基等，X表示氧原子或 类似，L表示键或类似物。
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公开(公告)号：US20120095031A1
公开(公告)日：2012-04-19
申请号：US13237205
申请日：2011-09-20
申请人： Taro Terauchi , Ayumi Takemura , Takashi Doko , Yu Yoshida , Toshiaki Tanaka , Keiichi Sorimachi , Yoshimitsu Naoe , Carsten Beuckmann , Yuji Kazuta
发明人： Taro Terauchi , Ayumi Takemura , Takashi Doko , Yu Yoshida , Toshiaki Tanaka , Keiichi Sorimachi , Yoshimitsu Naoe , Carsten Beuckmann , Yuji Kazuta
IPC分类号： A61K31/506 , A61P25/20 , A61K31/505 , C07D401/12 , C07D239/34
CPC分类号： C07D401/12 , C07D239/34
摘要： A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents —CH— or a nitrogen atom, R1a and R1b each independently represent a C1-6 alkyl group and the like, R1c represents a hydrogen atom and the like, R2a, R2b, R2c and R2d each independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group and the like, R3a, R3b and R3c each independently represent a hydrogen atom, a halogen atom and the like, and R3d represents a hydrogen atom and the like.
摘要翻译： 由下式（A）表示的环丙烷化合物或其药学上可接受的盐具有食欲肽受体拮抗作用，因此具有治疗食欲肽受体拮抗作用有效的睡眠障碍的潜在用途，例如失眠症：其中Q表示 -CH-或氮原子，R1a和R1b各自独立地表示C1-6烷基等，R1c表示氢原子等，R2a，R2b，R2c和R2d各自独立地表示氢原子，卤素原子 C 1-6烷基等，R 3a，R 3b和R 3c各自独立地表示氢原子，卤素原子等，R 3d表示氢原子等。
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