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    Process for production of optically active compounds
    1.
    发明授权
    Process for production of optically active compounds 失效
    光学活性化合物的制造方法

    公开(公告)号：US07084278B2

    公开(公告)日：2006-08-01

    申请号：US10506309

    申请日：2003-03-05

    申请人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

    发明人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

    IPC分类号： C07D213/16 ,  C07D213/28 ,  C07D233/64

    CPC分类号： C07D233/64 ,  C07D213/55

    摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.

    摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地 取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示 光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上定义 与下列通式表示的化合物：其中R 3，R 4和R 5如上所定义，X是卤代基 n原子。

    Method for producing optically active compound
    2.
    发明授权
    Method for producing optically active compound 失效
    光学活性化合物的制造方法

    公开(公告)号：US07629472B2

    公开(公告)日：2009-12-08

    申请号：US11812052

    申请日：2007-06-14

    申请人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

    发明人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

    IPC分类号： C07D233/54 ,  C07D211/80

    CPC分类号： C07D233/64 ,  C07D213/55

    摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.

    摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2表示与R 1不同的含氮杂环基，其表示为 通式：其中环可以被取代等，R 3表示任选取代的烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“* “表示光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上所定义，与通式表示的化合物反应：其中R 3，R 4和 R5如上所定义，X为卤素原子。

    Method for producing optically active compound
    3.
    发明申请
    Method for producing optically active compound 失效
    光学活性化合物的制造方法

    公开(公告)号：US20070276143A1

    公开(公告)日：2007-11-29

    申请号：US11812052

    申请日：2007-06-14

    申请人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

    发明人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

    IPC分类号： C07D233/54 ,  C07D211/80

    CPC分类号： C07D233/64 ,  C07D213/55

    摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2are as defined above with a compound represented by the general formula: wherein R3, R4and R5 are as defined above, and X is a halogen atom.

    摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地 取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示 光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上定义 与由下列通式表示的化合物：其中R 3，R 4和R 5如上定义，X​​是卤素 原子。

    Method for producing optically active compound
    4.
    发明授权
    Method for producing optically active compound 有权
    光学活性化合物的制造方法

    公开(公告)号：US07247732B2

    公开(公告)日：2007-07-24

    申请号：US11451051

    申请日：2006-06-12

    申请人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

    发明人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

    IPC分类号： C07D213/46 ,  C07D233/60

    CPC分类号： C07D233/64 ,  C07D213/55

    摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like,R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like,R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like,the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.

    摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地 取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示 光学活性中心，其包括在cinchona生物碱等存在下反应，由以下通式表示的化合物：其中R 1和R 2如上定义 与下列通式表示的化合物：其中R 3，R 4和R 5如上所定义，X是卤代基 n原子。

    Method for producing optically active compound
    5.
    发明申请
    Method for producing optically active compound 有权
    光学活性化合物的制造方法

    公开(公告)号：US20060229457A1

    公开(公告)日：2006-10-12

    申请号：US11451051

    申请日：2006-06-12

    申请人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

    发明人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

    IPC分类号： C07D233/61

    CPC分类号： C07D233/64 ,  C07D213/55

    摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.

    摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地 取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示 光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上定义 与下列通式表示的化合物：其中R 3，R 4和R 5如上所定义，X是卤代基 n原子。

    Process for production of optically active compounds
    6.
    发明申请
    Process for production of optically active compounds 失效
    光学活性化合物的制造方法

    公开(公告)号：US20050107433A1

    公开(公告)日：2005-05-19

    申请号：US10506309

    申请日：2003-03-05

    申请人： Toru Yamano ,  Naohiro Taya

    发明人： Toru Yamano ,  Naohiro Taya

    IPC分类号： C07D233/64 ,  C07B53/00 ,  C07B61/00 ,  C07D213/55 ,  C07D233/54 ,  C07D43/02 ,  A61K31/4025 ,  A61K31/454

    CPC分类号： C07D233/64 ,  C07D213/55

    摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.

    摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地 取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示 光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上定义 与下列通式表示的化合物：其中R 3，R 4和R 5如上所定义，X是卤代基 n原子。

    Process for producing optically active naphthalene derivative and optical resolver therefor
    7.
    发明授权
    Process for producing optically active naphthalene derivative and optical resolver therefor 失效
    用于制备光学活性萘衍生物和光学旋光器的方法

    公开(公告)号：US06800778B1

    公开(公告)日：2004-10-05

    申请号：US10111211

    申请日：2002-04-22

    申请人： Isao Aoki ,  Mari Adachi ,  Mitsuru Kawada ,  Toru Yamano ,  Naohiro Taya

    发明人： Isao Aoki ,  Mari Adachi ,  Mitsuru Kawada ,  Toru Yamano ,  Naohiro Taya

    IPC分类号： C07F906

    CPC分类号： C07D233/64 ,  A61K31/4164 ,  C07B2200/07 ,  C07F9/5027 ,  C07F9/65744

    摘要： The present invention provides a method of producing an optically active form of a compound represented by the formula (I) having a steroid C17,20-lyase inhibitory activity and is useful as an agent for the prophylaxis or treatment of prostatism, tumor such as breast cancer, and the like or a salt thereof, which method includes reacting a mixture of optically active compounds of a naphthalene derivative represented by the formula: wherein R is a nitrogen-containing heterocyclic group, R1 is a hydrogen atom, a hydrocarbon group or an aromatic heteromonocyclic group, R2 is a hydrogen atom or a lower alkyl group, * shows the position of an asymmetric carbon, R3, R4, R5, R6, R7, R8 and R9 are each independently a hydrogen atom, a hydrocarbon group, a hydroxy group, a thiol group, an amino group, a carbamoyl group, an acyl group or a halogen atom, and R7 is bonded with R6 or R8 to form, together with a carbon atom on a naphthalene ring, a 5 or 6-membered ring containing an oxygen atom, with an optically active form of a compound represented by the formula: wherein ring A is a benzene ring, R10 and R11 are the same or different and each is a hydrogen atom, a hydrocarbon group or a halogen atom, or R10 and R11 in combination show an alkylene group, * shows the position of an asymmetric carbon, and ring B and ring C are each an aromatic ring, separating the resulting salt, and isolating the optically active form, and a novel reagent for optical resolution.

    摘要翻译： 本发明提供了具有类固醇C17,20-裂解酶抑制活性的由式​​（I）表示的化合物的光学活性形式的方法，可用作预防或治疗前列腺症，肿瘤如乳腺癌 癌症等或其盐，该方法包括使由下式表示的萘衍生物的光学活性化合物的混合物：其中R是含氮杂环基，R 1是氢原子，烃 基团或芳族杂单环基团，R 2是氢原子或低级烷基，*表示不对称碳的位置，R 3，R 4，R 5，R 6， R 7，R 8和R 9各自独立地为氢原子，烃基，羟基，硫醇基，氨基，氨基甲酰基，酰基或卤素原子，以及 R 7与R 6或R 8键合，与萘环上的碳原子一起形成5或6元环， 具有下式表示的化合物的光学活性形式的氧原子：其中环A是苯环，R 10和R 11相同或不同，各自为氢原子，烃基 或卤素原子，或R 10和R 11组合表示亚烷基，*表示不对称碳的位置，环B和环C各自为芳环，分离所得盐，并分离 光学活性形式和用于光学拆分的新型试剂。