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公开(公告)号：US20130253322A1
公开(公告)日：2013-09-26
申请号：US13880569
申请日：2011-10-18
申请人： Toshihiko Suzuki , Yutaka Yamashita , Yukio Ueda , Etsuko Yamaki , Daisuke Yamashita , Kenji Yoshimoto , Harumi Sakahara , Hiroyuki Ogura , Hatsuko Nasu
发明人： Toshihiko Suzuki , Yutaka Yamashita , Yukio Ueda , Etsuko Yamaki , Daisuke Yamashita , Kenji Yoshimoto , Harumi Sakahara , Hiroyuki Ogura , Hatsuko Nasu
CPC分类号： A61B8/5261 , A61B5/0035 , A61B5/0073 , A61B5/0091 , A61B5/4312 , A61B5/6835 , A61B5/708 , A61B5/72 , A61B5/7425 , A61B8/0825 , A61B8/14 , A61B8/406 , A61B8/4227 , A61B8/4281 , A61B8/4416 , A61B8/4444 , A61B8/4455 , A61B8/4477 , A61B8/5207 , A61B10/0041 , A61B2562/146
摘要： A breast measurement apparatus comprises a receptacle for surrounding a breast; a plurality of optical fibers for irradiating the breast with examination light and detecting transmitted scattered light from the breast; an inner image generation unit for generating an optical CT image concerning the breast according to a detection signal of the transmitted scattered light; an ultrasonic probe, arranged so as to face the inside of the receptacle, for scanning the breast with an ultrasonic wave and receiving a reflected wave from the breast; an image generation unit for generating an ultrasonic image concerning the breast according to the reflected wave; and a mechanism for injecting and discharging a liquid interface agent into and from the inside of the receptacle.
摘要翻译： 乳房测量装置包括用于围绕乳房的容器; 多个光纤，用于用检查光照射乳房，并检测来自乳房的透射散射光; 内部图像生成单元，根据所发送的散射光的检测信号生成与乳房相关的光学CT图像; 超声波探头，布置成面向容器的内部，用于以超声波扫描乳房并从乳房接收反射波; 图像生成单元，其根据反射波生成与乳房相关的超声波图像; 以及用于将液体界面剂注入和排出到容器的内部的机构。
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公开(公告)号：US09427213B2
公开(公告)日：2016-08-30
申请号：US13880569
申请日：2011-10-18
申请人： Toshihiko Suzuki , Yutaka Yamashita , Yukio Ueda , Etsuko Yamaki , Daisuke Yamashita , Kenji Yoshimoto , Harumi Sakahara , Hiroyuki Ogura , Hatsuko Nasu
发明人： Toshihiko Suzuki , Yutaka Yamashita , Yukio Ueda , Etsuko Yamaki , Daisuke Yamashita , Kenji Yoshimoto , Harumi Sakahara , Hiroyuki Ogura , Hatsuko Nasu
CPC分类号： A61B8/5261 , A61B5/0035 , A61B5/0073 , A61B5/0091 , A61B5/4312 , A61B5/6835 , A61B5/708 , A61B5/72 , A61B5/7425 , A61B8/0825 , A61B8/14 , A61B8/406 , A61B8/4227 , A61B8/4281 , A61B8/4416 , A61B8/4444 , A61B8/4455 , A61B8/4477 , A61B8/5207 , A61B10/0041 , A61B2562/146
摘要： A breast measurement apparatus comprises a receptacle for surrounding a breast; a plurality of optical fibers for irradiating the breast with examination light and detecting transmitted scattered light from the breast; an inner image generation unit for generating an optical CT image concerning the breast according to a detection signal of the transmitted scattered light; an ultrasonic probe, arranged so as to face the inside of the receptacle, for scanning the breast with an ultrasonic wave and receiving a reflected wave from the breast; an image generation unit for generating an ultrasonic image concerning the breast according to the reflected wave; and a mechanism for injecting and discharging a liquid interface agent into and from the inside of the receptacle.
摘要翻译： 乳房测量装置包括用于围绕乳房的容器; 多个光纤，用于用检查光照射乳房，并检测来自乳房的透射散射光; 内部图像生成单元，根据所发送的散射光的检测信号生成与乳房相关的光学CT图像; 超声波探头，布置成面向容器的内部，用于以超声波扫描乳房并从乳房接收反射波; 图像生成单元，其根据反射波生成与乳房相关的超声波图像; 以及用于将液体界面剂注入和排出到容器的内部的机构。
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公开(公告)号：US20130100449A1
公开(公告)日：2013-04-25
申请号：US13695362
申请日：2011-03-29
申请人： Etsuko Yamaki , Yutaka Yamashita , Motoki Oda , Hiroaki Suzuki , Toshihiko Suzuki , Hiroshi Watanabe , Shunsaku Koga
发明人： Etsuko Yamaki , Yutaka Yamashita , Motoki Oda , Hiroaki Suzuki , Toshihiko Suzuki , Hiroshi Watanabe , Shunsaku Koga
IPC分类号： G01N21/17
CPC分类号： G01N21/17 , A61B5/14546 , A61B5/1455 , A61B2562/0242 , G01N21/359 , G01N21/49
摘要： Light irradiates one light incident position on the surface of a scattering-absorption body. The light that propagates through the interior of the scattering-absorption body is detected at one light detecting position on the surface of the scattering-absorption body. On the basis of a light detection signal, a temporal profile of the light intensity of the detected light is acquired, and on the basis of the temporal profile, an mean optical path length of the light in the interior of the scattering-absorption body and information relating to the amount of substance to be measured in a region to be measured are calculated. The information relating to the amount of substance to be measured is corrected on the basis of the mean optical path length, such that the longer the mean optical path length, the greater the amount of substance to be measured is.
摘要翻译： 光照射散射吸收体表面上的一个光入射位置。 在散射吸收体的表面的一个光检测位置处检测通过散射吸收体的内部传播的光。 基于光检测信号，获取检测光的光强度的时间分布，并且基于时间分布，散射吸收体内部的光的平均光路长度和 计算与要测量的区域中的待测物质量有关的信息。 基于平均光程长度校正与被测量物质量有关的信息，使得平均光程长度越长，待测物质量越多。
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公开(公告)号：US09506854B2
公开(公告)日：2016-11-29
申请号：US13695362
申请日：2011-03-29
申请人： Etsuko Yamaki , Yutaka Yamashita , Motoki Oda , Hiroaki Suzuki , Toshihiko Suzuki , Hiroshi Watanabe , Shunsaku Koga
发明人： Etsuko Yamaki , Yutaka Yamashita , Motoki Oda , Hiroaki Suzuki , Toshihiko Suzuki , Hiroshi Watanabe , Shunsaku Koga
IPC分类号： G01N21/17 , G01N21/49 , A61B5/1455 , G01N21/359 , A61B5/145
CPC分类号： G01N21/17 , A61B5/14546 , A61B5/1455 , A61B2562/0242 , G01N21/359 , G01N21/49
摘要： Light irradiates one light incident position on the surface of a scattering-absorption body. The light that propagates through the interior of the scattering-absorption body is detected at one light detecting position on the surface of the scattering-absorption body. On the basis of a light detection signal, a temporal profile of the light intensity of the detected light is acquired, and on the basis of the temporal profile, an mean optical path length of the light in the interior of the scattering-absorption body and information relating to the amount of substance to be measured in a region to be measured are calculated. The information relating to the amount of substance to be measured is corrected on the basis of the mean optical path length, such that the longer the mean optical path length, the greater the amount of substance to be measured is.
摘要翻译： 光照射散射吸收体表面上的一个光入射位置。 在散射吸收体的表面的一个光检测位置处检测通过散射吸收体的内部传播的光。 基于光检测信号，获取检测光的光强度的时间分布，并且基于时间分布，散射吸收体内部的光的平均光路长度和 计算与要测量的区域中的待测物质量有关的信息。 基于平均光程长度校正与被测量物质量有关的信息，使得平均光程长度越长，待测物质量越多。
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公开(公告)号：US20140135620A1
公开(公告)日：2014-05-15
申请号：US14130690
申请日：2012-06-28
申请人： Hiroyuki Kudo , Naoya Saito , Yukio Ueda , Kenji Yoshimoto , Yutaka Yamashita
发明人： Hiroyuki Kudo , Naoya Saito , Yukio Ueda , Kenji Yoshimoto , Yutaka Yamashita
CPC分类号： A61B5/7203 , A61B5/0073 , A61B5/0082 , A61B6/5247 , A61B8/15 , A61B8/5207 , A61B10/0041 , G01N21/4795 , G06T11/006
摘要： The bioinstrumentation apparatus includes a light irradiation unit irradiating a measurement region with light, a light detection unit detecting diffused light from the measurement region, and a computing unit generating a reconstructed image for the interior of the measurement region. The computing unit calculates J coefficients wj set for every pixel of the reconstructed image and more than 0 and not more than 1 (where J is the number of pixels of the reconstructed image) and carries out successive approximation computation by the following iterative formula xj(k+1)=xj(k)+wjdj(k) (where k is an integer from 1 to N, N is the number of times of iterative computation, xj(k) is a pixel value of the jth pixel on the kth iterative computation, and dj(k) is an update amount of the jth pixel on the kth iterative computation) to generate the reconstructed image.
摘要翻译： 生物仪器装置包括用光照射测量区域的光照射单元，检测来自测量区域的漫射光的光检测单元和产生测量区域内部的重建图像的计算单元。 计算单元计算对于重构图像的每个像素设置的J个系数wj，大于0且不大于1（其中J是重构图像的像素数），并且通过以下迭代公式xj执行逐次逼近计算 k + 1）= xj（k）+ wjdj（k）（其中k是从1到N的整数，N是迭代计算的次数，xj（k）是第k个像素的像素值 迭代计算，并且dj（k）是第k次迭代计算中的第j个像素的更新量）以生成重构图像。
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公开(公告)号：US09282932B2
公开(公告)日：2016-03-15
申请号：US14130690
申请日：2012-06-28
申请人： Hiroyuki Kudo , Naoya Saito , Yukio Ueda , Kenji Yoshimoto , Yutaka Yamashita
发明人： Hiroyuki Kudo , Naoya Saito , Yukio Ueda , Kenji Yoshimoto , Yutaka Yamashita
CPC分类号： A61B5/7203 , A61B5/0073 , A61B5/0082 , A61B6/5247 , A61B8/15 , A61B8/5207 , A61B10/0041 , G01N21/4795 , G06T11/006
摘要： The bioinstrumentation apparatus includes a light irradiation unit irradiating a measurement region with light, a light detection unit detecting diffused light from the measurement region, and a computing unit generating a reconstructed image for the interior of the measurement region. The computing unit calculates J coefficients wj set for every pixel of the reconstructed image and more than 0 and not more than 1 (where J is the number of pixels of the reconstructed image) and carries out successive approximation computation by the following iterative formula xj(k+1)=xj(k)+wjdj(k) (where k is an integer from 1 to N, N is the number of times of iterative computation, xj(k) is a pixel value of the jth pixel on the kth iterative computation, and dj(k) is an update amount of the jth pixel on the kth iterative computation) to generate the reconstructed image.
摘要翻译： 生物仪器装置包括用光照射测量区域的光照射单元，检测来自测量区域的漫射光的光检测单元和产生测量区域内部的重建图像的计算单元。 计算单元计算对于重构图像的每个像素设置的J个系数wj，大于0且不大于1（其中J是重构图像的像素数），并且通过以下迭代公式xj执行逐次逼近计算 k + 1）= xj（k）+ wjdj（k）（其中k是从1到N的整数，N是迭代计算的次数，xj（k）是第k个像素的像素值 迭代计算，并且dj（k）是第k次迭代计算中的第j个像素的更新量）以生成重构图像。
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公开(公告)号：US08279443B2
公开(公告)日：2012-10-02
申请号：US12672203
申请日：2008-10-10
申请人： Yukio Ueda , Yutaka Yamashita
发明人： Yukio Ueda , Yutaka Yamashita
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312 , G01N2201/0846
摘要： A bioinstrumentation apparatus irradiates light onto a measured region of a subject, detects diffused light to acquire internal information on the measured region, and includes: a container holding a light transmitting medium; a light irradiation unit including a plurality of light emitting ends fixed to the container and irradiating a first light and a second light that mutually differ in wavelength onto the measured region that is immersed in the medium; a light detection unit including a plurality of light detecting ends fixed to the container and detecting the diffused light from the measured region; and a computing unit computing the internal information based on an output signal from the light detection unit; the wavelength of the first light being a wavelength at which an absorption coefficient of the measured region and a mean value of absorption coefficient of the medium are substantially equal, the wavelength of the second light being a wavelength at which the absorption coefficient of the measured region is greater than the mean value of the absorption coefficient of the medium, and the computing unit computing the internal information based on an output signal related to diffused light of the first light and computing boundary information between the measured region and the medium based on an output signal related to diffused light of the second light.
摘要翻译： 生物测定装置将光照射到被检测体的测定区域，检测漫射光以获取测量区域的内部信息，并且包括：保持透光介质的容器; 光照射单元，其包括固定到所述容器的多个发光端，并且将相对不同波长的第一光和第二光照射到浸没在所述介质中的所述测量区域上; 光检测单元，其包括多个光检测端，固定到所述容器并检测来自所述测量区域的漫射光; 以及计算单元，基于来自所述光检测单元的输出信号来计算所述内部信息; 所述第一光的波长是所述测定区域的吸收系数和所述介质的吸收系数的平均值基本相等的波长，所述第二光的波长为所述测定区域的吸收系数的波长 大于所述介质的吸收系数的平均值，并且所述计算单元基于与所述第一光的漫射光相关的输出信号和基于所述测量区域与所述介质之间的计算边界信息的输出来计算所述内部信息 与第二光的漫射光有关的信号。
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公开(公告)号：US20110063624A1
公开(公告)日：2011-03-17
申请号：US12672203
申请日：2008-10-10
申请人： Yukio Ueda , Yutaka Yamashita
发明人： Yukio Ueda , Yutaka Yamashita
IPC分类号： G01N21/17
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312 , G01N2201/0846
摘要： A bioinstrumentation apparatus irradiates light onto a measured region of a subject, detects diffused light to acquire internal information on the measured region, and includes: a container holding a light transmitting medium; a light irradiation unit including a plurality of light emitting ends fixed to the container and irradiating a first light and a second light that mutually differ in wavelength onto the measured region that is immersed in the medium; a light detection unit including a plurality of light detecting ends fixed to the container and detecting the diffused light from the measured region; and a computing unit computing the internal information based on an output signal from the light detection unit; the wavelength of the first light being a wavelength at which an absorption coefficient of the measured region and a mean value of absorption coefficient of the medium are substantially equal, the wavelength of the second light being a wavelength at which the absorption coefficient of the measured region is greater than the mean value of the absorption coefficient of the medium, and the computing unit computing the internal information based on an output signal related to diffused light of the first light and computing boundary information between the measured region and the medium based on an output signal related to diffused light of the second light.
摘要翻译： 生物测定装置将光照射到被检测体的测定区域，检测漫射光以获取测量区域的内部信息，并且包括：保持透光介质的容器; 光照射单元，其包括固定到所述容器的多个发光端，并且将相对不同波长的第一光和第二光照射到浸没在所述介质中的所述测量区域上; 光检测单元，其包括多个光检测端，固定到所述容器并检测来自所述测量区域的漫射光; 以及计算单元，基于来自所述光检测单元的输出信号来计算所述内部信息; 所述第一光的波长是所述测定区域的吸收系数和所述介质的吸收系数的平均值基本相等的波长，所述第二光的波长为所述测定区域的吸收系数的波长 大于所述介质的吸收系数的平均值，并且所述计算单元基于与所述第一光的漫射光相关的输出信号和基于所述测量区域与所述介质之间的计算边界信息的输出来计算所述内部信息 与第二光的漫射光有关的信号。
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公开(公告)号：US20090270846A1
公开(公告)日：2009-10-29
申请号：US12091075
申请日：2006-10-25
申请人： Hiroyuki Okada , Teiji Nakayama , Kazuo Umemura , Daisuke Yamashita , Yutaka Yamashita , Katsuhiro Kobayashi
发明人： Hiroyuki Okada , Teiji Nakayama , Kazuo Umemura , Daisuke Yamashita , Yutaka Yamashita , Katsuhiro Kobayashi
IPC分类号： A61B18/24
CPC分类号： A61B18/24 , A61B90/39 , A61M5/007 , A61M2025/0037
摘要： The position of a metal marker 5 relative to an optical fiber 6 is fixed, and the metal marker 5 can be moved up close to a target site such as a thrombus. It is preferable that the position, in an optical fiber longitudinal direction, of a front-end face of the optical fiber 6 is coincident with the position, in an optical fiber longitudinal direction, of a front-end face of the metal marker 5. More specifically, since the distance between the target site and the front end of the optical fiber 6 is known by radiography, it becomes unnecessary to use a large quantity of contrast agent and irradiate a laser beam depending on skill and intuition, and therefore an effective laser beam irradiation becomes possible.
摘要翻译： 金属标记物5相对于光纤6的位置是固定的，并且金属标记物5能够靠近靶位置如血栓移动。 优选的是，光纤6的前端面的光纤长度方向与金属标记5的前端面的光纤长度方向的位置一致。 更具体地说，由于通过射线照相方法已知目标部位与光纤6的前端之间的距离，所以根据技能和直觉，不需要使用大量的造影剂并照射激光束，因此有效 激光束照射成为可能。
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公开(公告)号：US20070038116A1
公开(公告)日：2007-02-15
申请号：US10565833
申请日：2004-07-23
申请人： Takeshi Yamanaka , Yukio Ueda , Yutaka Yamashita
发明人： Takeshi Yamanaka , Yukio Ueda , Yutaka Yamashita
IPC分类号： A61B6/00
CPC分类号： G01N21/4795 , A61B5/14553 , A61B2562/0233 , A61B2562/046 , G01N21/49
摘要： A scattering medium measuring apparatus is composed of: a measuring module 1 having an irradiation probe 11 and detection probes 61 and 71; and a measuring module 2 having an irradiation probe 21 and detection probes 81 and 91. There is also provided an optical delay device 22 between a pulse light source 30 as a common light source for the irradiation probes 11 and 21 and the irradiation probe 21 so that pulse light is irradiated successively from the irradiation probes 11 and 21. A trigger circuit 50 is adapted to instruct the light source 30 on the irradiation timing of pulse light and signal processing circuits 62 to 92 corresponding to the detection timing of the corresponding light synchronized with the irradiation timing. This can achieve a scattering medium measuring apparatus and measuring method capable of suppressing crosstalk between channels without a spatial restriction.
摘要翻译： 散射介质测量装置包括：具有照射探针11和检测探头61和71的测量模块1; 以及具有照射探针21和检测用探针81,91的测定模块2.另外，在作为照射探测器11,21的共用光源的脉冲光源30和照射探测器21之间，还设有光学延迟装置22 从照射探头11和21依次照射脉冲光。触发电路50适于根据对应的光的同步的检测定时对脉冲光的照射定时和信号处理电路62至92指示光源30 具有照射时间。 这可以实现能够抑制通道之间的串扰而没有空间限制的散射介质测量装置和测量方法。
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