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公开(公告)号：US20070172891A1
公开(公告)日：2007-07-26
申请号：US11656945
申请日：2007-01-24
CPC分类号： G01N33/54373 , B01L3/502 , G01N35/00594
摘要： Reference data are subtracted from corresponding actual measurement data, and unprocessed binding quantity data, each of which represents a quantity of binding of a ligand and each of analytes, are thereby acquired. Calculation is made to find a relationship between the reference data and the unprocessed binding quantity data acquired in cases where the binding does not occur. In accordance with the relationship, variation components, which are contained in the unprocessed binding quantity data, are calculated. The variation components are subtracted from the corresponding unprocessed binding quantity data, and processed binding quantity data are thereby acquired. The processed binding quantity data are utilized for extracting an analyte capable of binding with the ligand.
摘要翻译： 从相应的实际测量数据中减去参考数据，从而获得每个表示配体和每种分析物的结合量的未处理的结合量数据。 进行计算，以在不发生绑定的情况下找到参考数据与未处理的绑定量数据之间的关系。 根据该关系，计算包含在未处理的装订量数据中的变化成分。 从相应的未处理的装订量数据中减去变化分量，从而获得处理的装订量数据。 处理的结合量数据用于提取能够与配体结合的分析物。
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公开(公告)号：US07885769B2
公开(公告)日：2011-02-08
申请号：US11656945
申请日：2007-01-24
IPC分类号： G01N33/48
CPC分类号： G01N33/54373 , B01L3/502 , G01N35/00594
摘要： Reference data are subtracted from corresponding actual measurement data, and unprocessed binding quantity data, each of which represents a quantity of binding of a ligand and each of analytes, are thereby acquired. Calculation is made to find a relationship between the reference data and the unprocessed binding quantity data acquired in cases where the binding does not occur. In accordance with the relationship, variation components, which are contained in the unprocessed binding quantity data, are calculated. The variation components are subtracted from the corresponding unprocessed binding quantity data, and processed binding quantity data are thereby acquired. The processed binding quantity data are utilized for extracting an analyte capable of binding with the ligand.
摘要翻译： 从相应的实际测量数据中减去参考数据，从而获得每个表示配体和各分析物的结合量的未处理的结合量数据。 进行计算，以在不发生绑定的情况下找到参考数据与未处理的绑定量数据之间的关系。 根据关系，计算包含在未处理的装订量数据中的变化分量。 从相应的未处理的装订量数据中减去变化分量，从而获得处理的装订量数据。 处理的结合量数据用于提取能够与配体结合的分析物。
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公开(公告)号：US20050112028A1
公开(公告)日：2005-05-26
申请号：US10947285
申请日：2004-09-23
申请人： Hisashi Ohtsuka , Toshihito Kimura
发明人： Hisashi Ohtsuka , Toshihito Kimura
CPC分类号： G01N21/553 , G01N21/0332 , G01N2021/0382
摘要： A surface plasmon resonance sensor includes a light source emitting a light beam, a metal film provided on one surface of the dielectric block of a sensor unit, a light beam projecting system which causes the light beam to enter the dielectric block to impinge upon the interface between said one surface of the dielectric block and the metal film so that total internal reflection conditions are satisfied at the interface, and a photodetector which detects the intensity of the light beam reflected in total internal reflection at the interface and detects a state of attenuation in total internal reflection. The relation −2×10−5≦(n3·Δn1−n1·Δn3)≦2×10−5 is satisfied wherein n1 and n3 represent refractive indexes of the solvent of the sample liquid and the dielectric block, and Δn1 and Δn3 represent the rates of temperature-change of the refractive indexes of the solvent of the sample liquid and the dielectric block.
摘要翻译： 表面等离子体共振传感器包括发射光束的光源，设置在传感器单元的介质块的一个表面上的金属膜，使光束进入介质块以撞击接口的光束投影系统 在所述介质块的所述一个表面和所述金属膜之间，使得在所述界面处满足全内反射条件，以及光电检测器，其检测在所述界面处的全内反射中反射的光束的强度，并且检测所述介质块的衰减状态 全内反射。 满足关系-2×10 -5 <=（n3.Deltan1-n1.Deltan3）<= 2×10 -5其中n1和n3表示溶剂的折射率 样品液体和介质块，Deltan1和Deltan3表示样品液体和介质块的溶剂的折射率的温度变化率。
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4.发明申请公开(公告)号：US20050030543A1
公开(公告)日：2005-02-10
申请号：US10932270
申请日：2004-09-02
CPC分类号： G01N21/553 , G01N21/43
摘要： A state of attenuation in total internal reflection is detected by the use of a measuring apparatus having a measuring unit and a reference unit and a measuring system which corrects result of detection by the measuring unit on the basis of result of detection by the reference unit and measures the change of a state of attenuation in total internal reflection on the basis of the corrected result of detection by the measuring unit. The difference in sensitivity between the measuring unit and the reference unit is detected before initiating the measurement of the change of a state of attenuation in total internal reflection, and result of measurement by the measuring system is calibrated on the basis of the difference in sensitivity between the measuring unit and the reference unit.
摘要翻译： 通过使用具有测量单元和参考单元的测量装置以及基于由参考单元的检测结果校正测量单元的检测结果的测量系统来检测全内反射的衰减状态，以及 根据校正检测结果，测量全内反射的衰减状态的变化。 在开始测量全内反射中的衰减状态的测量之前，检测测量单元和参考单元之间的灵敏度差异，并且基于测量系统的灵敏度差校正测量系统的结果， 测量单元和参考单元。
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5.发明申请公开(公告)号：US20060066861A1
公开(公告)日：2006-03-30
申请号：US11239305
申请日：2005-09-30
申请人： Shu Sato , Toshihito Kimura , Hisashi Ohtsuka
发明人： Shu Sato , Toshihito Kimura , Hisashi Ohtsuka
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A measurement path is filled with air prior to performing actual measurement. A p-polarized light beam is caused to enter an interface, and the intensity distribution of the light beam reflected at the interface is detected by a photodiode array to obtain a reference intensity distribution of the light beam itself. Thereafter, the measurement path is filled with a target for measurement, and the intensity distribution of a light beam reflected at the interface is measured. Each of the measured distribution values are divided by the reference intensity distribution, to cancel out influences due to fluctuations in the intensity distribution of the light beam. Thereby, the position of an attenuated total reflection angle is detected with high accuracy. Because a light beam constituted by p-polarized light waves is utilized, separating means for separating the light beam reflected at the interface into p-polarized and s-polarized light waves becomes unnecessary.
摘要翻译： 在执行实际测量之前，测量路径充满空气。 使p偏振光束进入界面，并且通过光电二极管阵列检测在界面处反射的光束的强度分布，以获得光束本身的参考光强分布。 此后，用测量目标填充测量路径，并且测量在界面处反射的光束的强度分布。 每个测量分布值除以参考强度分布，以消除由于光束的强度分布的波动引起的影响。 从而，以高精度检测衰减的全反射角度的位置。 由于利用由p偏振光波构成的光束，所以不需要用于将在界面处反射的光束分离为p偏振光和S偏振光波的分离装置。
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6.发明授权公开(公告)号：US06791691B2
公开(公告)日：2004-09-14
申请号：US10273270
申请日：2002-10-18
IPC分类号： G01N2155
CPC分类号： G01N21/553 , G01N21/43
摘要： A state of attenuation in total internal reflection is detected by the use of a measuring apparatus having a measuring unit and a reference unit and a measuring system which corrects result of detection by the measuring unit on the basis of result of detection by the reference unit and measures the change of a state of attenuation in total internal reflection on the basis of the corrected result of detection by the measuring unit. The difference in sensitivity between the measuring unit and the reference unit is detected before initiating the measurement of the change of a state of attenuation in total internal reflection, and result of measurement by the measuring system is calibrated on the basis of the difference in sensitivity between the measuring unit and the reference unit.
摘要翻译： 通过使用具有测量单元和参考单元的测量装置以及基于由参考单元的检测结果校正测量单元的检测结果的测量系统来检测全内反射的衰减状态，以及 根据校正检测结果，测量全内反射的衰减状态的变化。 在开始测量全内反射中的衰减状态的测量之前，检测测量单元和参考单元之间的灵敏度差异，并且基于测量系统的灵敏度差校正测量系统的结果， 测量单元和参考单元。
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公开(公告)号：US07102754B2
公开(公告)日：2006-09-05
申请号：US10932270
申请日：2004-09-02
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/43
摘要： A state of attenuation in total internal reflection is detected by the use of a measuring apparatus having a measuring unit and a reference unit and a measuring system which corrects result of detection by the measuring unit on the basis of result of detection by the reference unit and measures the change of a state of attenuation in total internal reflection on the basis of the corrected result of detection by the measuring unit. The difference in sensitivity between the measuring unit and the reference unit is detected before initiating the measurement of the change of a state of attenuation in total internal reflection, and result of measurement by the measuring system is calibrated on the basis of the difference in sensitivity between the measuring unit and the reference unit.
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8.发明授权公开(公告)号：US07365853B2
公开(公告)日：2008-04-29
申请号：US11239305
申请日：2005-09-30
申请人： Shu Sato , Toshihito Kimura , Hisashi Ohtsuka
发明人： Shu Sato , Toshihito Kimura , Hisashi Ohtsuka
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A measurement path is filled with air prior to performing actual measurement. A p-polarized light beam is caused to enter an interface, and the intensity distribution of the light beam reflected at the interface is detected by a photodiode array to obtain a reference intensity distribution of the light beam itself. Thereafter, the measurement path is filled with a target for measurement, and the intensity distribution of a light beam reflected at the interface is measured. Each of the measured distribution values are divided by the reference intensity distribution, to cancel out influences due to fluctuations in the intensity distribution of the light beam. Thereby, the position of an attenuated total reflection angle is detected with high accuracy. Because a light beam constituted by p-polarized light waves is utilized, separating means for separating the light beam reflected at the interface into p-polarized and s-polarized light waves becomes unnecessary.
摘要翻译： 在执行实际测量之前，测量路径充满空气。 使p偏振光束进入界面，并且通过光电二极管阵列检测在界面处反射的光束的强度分布，以获得光束本身的参考光强分布。 此后，用测量目标填充测量路径，并且测量在界面处反射的光束的强度分布。 每个测量分布值除以参考强度分布，以消除由于光束的强度分布的波动引起的影响。 从而，以高精度检测衰减的全反射角度的位置。 由于利用由p偏振光波构成的光束，所以不需要用于将在界面处反射的光束分离为p偏振光和S偏振光波的分离装置。
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公开(公告)号：US20080219893A1
公开(公告)日：2008-09-11
申请号：US12042884
申请日：2008-03-05
申请人： Hisashi Ohtsuka
发明人： Hisashi Ohtsuka
IPC分类号： G01N21/64
CPC分类号： G01N21/648
摘要： A first substance capable of undergoing binding with a substance to be detected in a sample is fixed to a detecting section. A plurality of pieces of a second substance capable of undergoing the binding with the substance to be detected are mixed in the sample. Each of fine metal particles has been bound with one of the pieces of the second substance. A fluorescent substance has been combined with each pair of the fine metal particle and the piece of the second substance into an integral body. Exciting light capable of exciting the fluorescent substance is irradiated to the detecting section, and fluorescence produced by the fluorescent substance is detected.
摘要翻译： 能够在样品中与被检测物质结合的第一物质固定在检测部上。 能够与待检测物质结合的多个第二物质在样品中混合。 每个细金属颗粒已经与第二物质中的一个结合。 已将荧光物质与每一对细金属颗粒和第二物质组合成一体。 能够激发荧光物质的激发光被照射到检测部分，并且检测由荧光物质产生的荧光。
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10.发明申请Laser-diode-excited laser apparatus, fiber laser apparatus, and fiber laser amplifier in which laser medium doped with one of Ho3+, Sm3+, Eu3+, Dy3+, Er3+, and Tb3+ is excited with GaN-based compound laser diode 失效激光二极管激光装置，光纤激光装置和光纤激光放大器，其中掺杂有Ho3 +，Sm3 +，Eu3 +，Dy3 +，Er3 +和Tb3 +之一的激光介质被GaN基复合激光二极管公开(公告)号：US20050047468A1
公开(公告)日：2005-03-03
申请号：US10952719
申请日：2004-09-30
申请人： Hisashi Ohtsuka , Yoji Okazaki , Takayuki Katoh
发明人： Hisashi Ohtsuka , Yoji Okazaki , Takayuki Katoh
CPC分类号： H01S3/067 , H01S3/025 , H01S3/0405 , H01S3/042 , H01S3/0602 , H01S3/09415 , H01S3/109 , H01S3/1603 , H01S3/161 , H01S3/1615 , H01S5/32341 , H01S2302/00
摘要： A solid-state laser crystal constituting a laser-diode-excited solid-state laser apparatus or an optical fiber constituting a fiber laser apparatus or fiber laser amplifier is doped with one of Ho3+, Sm3+, Eu3+, Dy3+, Er3+, and Tb3+ so that a laser beam is emitted from the solid-state laser crystal or the optical fiber, or incident light of the fiber laser amplifier is amplified, by one of the transitions from 5S2 to 5I7, from 5S2 to 5I8, from 4G5/2 to 6H5/2, from 4G5/2 to 6H7/2, from 4F3/2 to 6H11/2, from 5D0 to 7F2, from 4F9/2 to 6H13/2, from 4F9/2 to 6H11/2, from 4S3/2 to 4I15/2, from 2H9/2 to 4I13/2, and from 5D4 to 7F5. The above solid-state laser-crystal or optical fiber is excited with a GaN-based compound laser diode.
摘要翻译： 构成激光二极管激光固体激光装置的固态激光晶体或构成光纤激光装置或光纤激光放大器的光纤掺杂有Ho 3+，Sm 3+， 3+，Dy 3+，Er 3+和Tb 3+，使得激光束从固态激光晶体或光纤发射，或者光纤激光放大器的入射光为 通过从<5> S2至<5> I7的从5S→5J8→4G5 / 2→6H5 / 2→4G5 / 2〜6 H7 / 2，从F3 / 2〜6H11 / 2，从5℃到0℃的F2，从F9 / 2到6的H13 / 2， 从4/3> 3/1> 1/2，从4/3> 911/2到<6> H11 / 2，从S3 / D4至<7> F5。 上述固态激光晶体或光纤被GaN基复合激光二极管激发。
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