公开(公告)号：US11684404B2

公开(公告)日：2023-06-27

申请号：US17690948

申请日：2022-03-09

Applicant: Trustees of Boston University

Inventor： Chen Yang ,  Ji-Xin Cheng ,  Nan Zheng ,  Yueming Li ,  Ying Jiang ,  Lu Lan ,  Linli Shi

IPC: A61B18/04 ,  B01J19/10 ,  B82Y40/00 ,  B82Y30/00 ,  A61B5/00 ,  A61B18/26 ,  A61B8/00 ,  A61B18/22 ,  G01N29/24 ,  G01S15/89 ,  F21V8/00 ,  G02B6/02 ,  G02B6/34

CPC classification number: A61B18/04 ,  A61B5/0095 ,  A61B18/26 ,  B01J19/10 ,  B82Y30/00 ,  B82Y40/00 ,  A61B5/0035 ,  A61B5/0059 ,  A61B8/4416 ,  A61B8/4483 ,  A61B2018/2205 ,  A61B2018/2244 ,  A61B2018/2261 ,  A61B2018/266 ,  G01N29/2431 ,  G01S15/8968 ,  G02B6/004 ,  G02B6/021 ,  G02B6/02033 ,  G02B6/02104 ,  G02B6/34

Abstract: A tapered fiber optoacoustic emitter includes a nanosecond laser configured to emit laser pulses and an optic fiber. The optic fiber includes a tip configured to guide the laser pulses. The tip has a coating including a diffusion layer and a thermal expansion layer, wherein the diffusion layer includes epoxy and zinc oxide nanoparticles configured to diffuse the light while restricting localized heating. The thermal expansion layer includes carbon nanotubes (CNTs) and Polydimethylsiloxane (PDMS) configured to convert the laser pulses to generate ultrasound. The frequency of the ultrasound is tuned with a thickness of the diffusion layer and a CNT concentration of the expansion layer.

公开(公告)号：US11564742B2

公开(公告)日：2023-01-31

申请号：US17737710

申请日：2022-05-05

Applicant: Trustees of Boston University

Inventor： Chen Yang ,  Ji-Xin Cheng ,  Nan Zheng ,  Yueming Li ,  Ying Jiang ,  Lu Lan ,  Carolyn Marar

IPC: A61B18/18 ,  H01P7/08

Abstract: A system for neuromodulation includes a split-ring resonator (SRR) comprising a resonance circuit, the SRR being implantable in a cranial target site and a source of microwave signals, wherein the microwave signals are deliverable wirelessly to couple with the SRR to produce a localized electrical field, wherein the localized electrical field inhibits one or more neurons at the cranial target site with submillimeter spatial precision.

公开(公告)号：US20220354573A1

公开(公告)日：2022-11-10

申请号：US17737710

申请日：2022-05-05

Applicant: Trustees of Boston University

Inventor： Chen Yang ,  Ji-Xin Cheng ,  Nan Zheng ,  Yueming Li ,  Ying Jiang ,  Lu Lan ,  Carolyn Marar

IPC: A61B18/18 ,  H01P7/08

Abstract: A system for neuromodulation includes a split-ring resonator (SRR) comprising a resonance circuit, the SRR being implantable in a cranial target site and a source of microwave signals, wherein the microwave signals are deliverable wirelessly to couple with the SRR to produce a localized electrical field, wherein the localized electrical field inhibits one or more neurons at the cranial target site with submillimeter spatial precision.

公开(公告)号：US20220287758A1

公开(公告)日：2022-09-15

申请号：US17690948

申请日：2022-03-09

Applicant: Trustees of Boston University

Inventor： Chen Yang ,  Ji-Xin Cheng ,  Nan Zheng ,  Yueming Li ,  Ying Jiang ,  Lu Lan ,  Linli Shi

IPC: A61B18/04 ,  B82Y30/00 ,  B82Y40/00 ,  B01J19/10

Abstract: A tapered fiber optoacoustic emitter includes a nanosecond laser configured to emit laser pulses and an optic fiber. The optic fiber includes a tip configured to guide the laser pulses. The tip has a coating including a diffusion layer and a thermal expansion layer, wherein the diffusion layer includes epoxy and zinc oxide nanoparticles configured to diffuse the light while restricting localized heating. The thermal expansion layer includes carbon nanotubes (CNTs) and Polydimethylsiloxane (PDMS) configured to convert the laser pulses to generate ultrasound. The frequency of the ultrasound is tuned with a thickness of the diffusion layer and a CNT concentration of the expansion layer.

公开(公告)号：US20230285063A1

公开(公告)日：2023-09-14

申请号：US18196698

申请日：2023-05-12

Applicant: Trustees of Boston University

Inventor： Chen Yang ,  Ji-Xin Cheng ,  Nan Zheng ,  Yueming Li ,  Ying Jiang ,  Lu Lan ,  Linli Shi

IPC: A61B18/04 ,  B01J19/10 ,  B82Y40/00 ,  B82Y30/00 ,  A61B5/00 ,  A61B18/26

CPC classification number: A61B18/04 ,  B01J19/10 ,  B82Y40/00 ,  B82Y30/00 ,  A61B5/0095 ,  A61B18/26 ,  A61B5/0035 ,  A61B5/0059 ,  A61B8/4416

Abstract: A tapered fiber optoacoustic emitter includes a nanosecond laser configured to emit laser pulses and an optic fiber. The optic fiber includes a tip configured to guide the laser pulses. The tip has a coating including a diffusion layer and a thermal expansion layer, wherein the diffusion layer includes epoxy and zinc oxide nanoparticles configured to diffuse the light while restricting localized heating. The thermal expansion layer includes carbon nanotubes (CNTs) and Polydimethylsiloxane (PDMS) configured to convert the laser pulses to generate ultrasound. The frequency of the ultrasound is tuned with a thickness of the diffusion layer and a CNT concentration of the expansion layer.

公开(公告)号：US20230140692A1

公开(公告)日：2023-05-04

申请号：US18089122

申请日：2022-12-27

Applicant: Trustees of Boston University

Inventor： Chen Yang ,  Ji-Xin Cheng ,  Nan Zheng ,  Yueming Li ,  Ying Jiang ,  Lu Lan ,  Carolyn Marar

IPC: A61B18/18 ,  H01P7/08

Abstract: A system for neuromodulation includes a split-ring resonator (SRR) comprising a resonance circuit, the SRR being implantable in a cranial target site and a source of microwave signals, wherein the microwave signals are deliverable wirelessly to couple with the SRR to produce a localized electrical field, wherein the localized electrical field inhibits one or more neurons at the cranial target site with submillimeter spatial precision.