Antibody-induced apoptosis
    1.
    发明授权
    Antibody-induced apoptosis 失效
    抗体诱导凋亡

    公开(公告)号:US06458356B1

    公开(公告)日:2002-10-01

    申请号:US09046785

    申请日:1998-03-23

    IPC分类号: A61K39395

    摘要: Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to “tag” Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods for treating cancer using the antibodies, and pharmaceutical compositions.

    摘要翻译: 公开了在Her2表达细胞中诱导凋亡的抗Her2抗体。 该抗体用于“标记”Her2过表达的肿瘤以通过宿主免疫系统消除。 还公开了产生抗体的杂交瘤细胞系,使用该抗体治疗癌症的方法和药物组合物。

    Antibody-induced apoptosis
    2.
    发明授权
    Antibody-induced apoptosis 有权
    抗体诱导凋亡

    公开(公告)号:US07354583B2

    公开(公告)日:2008-04-08

    申请号:US09994068

    申请日:2001-11-27

    IPC分类号: A61K39/395 C12N5/12

    摘要: Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to “tag” Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods for treating cancer using the antibodies, and pharmaceutical compositions.

    摘要翻译: 公开了在Her2表达细胞中诱导凋亡的抗Her2抗体。 该抗体用于“标记”Her2过表达的肿瘤以通过宿主免疫系统消除。 还公开了产生抗体的杂交瘤细胞系,使用该抗体治疗癌症的方法和药物组合物。

    ANTIBODY-INDUCED APOPTOSIS
    3.
    发明申请
    ANTIBODY-INDUCED APOPTOSIS 失效
    抗体诱导的病变

    公开(公告)号:US20110189168A1

    公开(公告)日:2011-08-04

    申请号:US12901435

    申请日:2010-10-08

    摘要: Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to “tag” Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods for treating cancer using the antibodies, and pharmaceutical compositions.

    摘要翻译: 公开了在Her2表达细胞中诱导凋亡的抗Her2抗体。 该抗体用于“标记”Her2过表达的肿瘤以通过宿主免疫系统消除。 还公开了产生抗体的杂交瘤细胞系,使用该抗体治疗癌症的方法和药物组合物。

    Antibody-induced apoptosis
    5.
    发明授权
    Antibody-induced apoptosis 有权
    抗体诱导凋亡

    公开(公告)号:US07811566B2

    公开(公告)日:2010-10-12

    申请号:US11981562

    申请日:2007-10-30

    IPC分类号: A61K39/395

    摘要: Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to “tag” Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods for treating cancer using the antibodies, and pharmaceutical compositions.

    摘要翻译: 公开了在Her2表达细胞中诱导凋亡的抗Her2抗体。 该抗体用于“标记”Her2过表达的肿瘤以通过宿主免疫系统消除。 还公开了产生抗体的杂交瘤细胞系,使用该抗体治疗癌症的方法和药物组合物。

    METHOD FOR IMPROVING RECOVERY YIELD IN PROTEIN PURIFICATION WITH GEL FILTRATION CHROMATOGRAPHY
    9.
    发明申请
    METHOD FOR IMPROVING RECOVERY YIELD IN PROTEIN PURIFICATION WITH GEL FILTRATION CHROMATOGRAPHY 有权
    改进凝胶过滤色谱法提纯蛋白质回收率的方法

    公开(公告)号:US20060199948A1

    公开(公告)日:2006-09-07

    申请号:US11276509

    申请日:2006-03-03

    IPC分类号: C07K16/00 C07K1/10

    摘要: A method to more quantitatively recover a peak of a protein and associated aggregates, hydrophobic proteins, or hydrophobic peptides which are typically difficult to recover and detect as a peak, using a commercially available gel filtration chromatography column and a mobile phase is described. More specifically, a compound, such as arginine, which may be added to the mobile phase, thereby eliminating the unnecessary interaction that occurs between the proteins, peptides, or aggregates and the column stationary phase is described.

    摘要翻译: 描述了使用市售的凝胶过滤色谱柱和流动相来更定量地回收通常难以回收和检测作为峰的相关聚集体,疏水性蛋白质或疏水性肽的峰值的方法。 更具体地,描述了可以添加到流动相中的化合物,例如精氨酸,从而消除了在蛋白质,肽或聚集体和柱固定相之间发生的不必要的相互作用。