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15 条记录 (耗时 0.019 秒)

    Insoluble powder, powder for restoring barrier function of skin, powder for preventing/mitigating skin chapping, and preparation containing the same for external use on skin
    1.
    发明授权
    Insoluble powder, powder for restoring barrier function of skin, powder for preventing/mitigating skin chapping, and preparation containing the same for external use on skin 有权
    不溶性粉末，用于恢复皮肤屏障功能的粉末，用于预防/缓解皮肤裂纹的粉末，以及含有外用皮肤的制剂

    公开(公告)号：US07785636B2

    公开(公告)日：2010-08-31

    申请号：US10509539

    申请日：2003-03-28

    申请人： Shigeyoshi Fujiwara ,  Mitsuhiro Denda ,  Katsuki Ogawa ,  Tsuyoshi Miyamoto ,  Sadaki Takata

    发明人： Shigeyoshi Fujiwara ,  Mitsuhiro Denda ,  Katsuki Ogawa ,  Tsuyoshi Miyamoto ,  Sadaki Takata

    IPC分类号： A61K33/04

    CPC分类号： A61Q1/12 ,  A61K8/022 ,  A61K8/19 ,  A61K8/23 ,  A61K8/27 ,  A61K2800/412 ,  A61K2800/651 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/08

    摘要： A first subject of the present invention is an insoluble powder characterized in that a zeta-potential is a negative value.It is preferable that barium sulfate is a main ingredient in the insoluble powder.It is preferable that an average primary particle diameter is 3 to 100 μm, and an aspect ratio is 3 to 250 in the insoluble powder.It is preferable that the insoluble powder is a metal-doped barium sulfate powder obtained by reacting a barium ion and a sulfate ion in the presence of a metal ion.It is preferable that the metal ion is one or more selected from the group consisting of a lithium ion, a sodium ion and a zinc ion in the insoluble powder.A second subject of the present invention is a skin barrier function recovering powder, or a skin roughening preventing and improving powder, which comprises the aforementioned powder.A third subject of the present invention is a skin external composition characterized in that a content of the aforementioned powder is 1 to 40% by weight.

    摘要翻译： 本发明的第一个目标是不溶性粉末，其特征在于ζ电位是负值。 优选硫酸钡是不溶性粉末的主要成分。 在不溶性粉末中，平均一次粒径优选为3〜100μm，长径比为3〜250。 优选不溶性粉末是在金属离子存在下使钡离子和硫酸根离子反应而得到的金属掺杂硫酸钡粉末。 金属离子优选在不溶性粉末中选自锂离子，钠离子和锌离子中的一种以上。 本发明的第二主题是包含上述粉末的皮肤屏障功能回收粉末或皮肤粗糙化防止和改善粉末。 本发明的第三主题是皮肤外用组合物，其特征在于上述粉末的含量为1〜40重量％。

    Skin barrier function recovery and promotion composition and evaluation method thereof
    5.
    发明授权
    Skin barrier function recovery and promotion composition and evaluation method thereof 有权
    皮肤屏障功能恢复及促进作用及其评价方法

    公开(公告)号：US06315980B1

    公开(公告)日：2001-11-13

    申请号：US09400534

    申请日：1999-09-21

    申请人： Mitsuhiro Denda ,  Toru Tsuchiya ,  Masahiro Tanida ,  Ken Shoji

    发明人： Mitsuhiro Denda ,  Toru Tsuchiya ,  Masahiro Tanida ,  Ken Shoji

    IPC分类号： A61K5100

    CPC分类号： A61Q17/00 ,  A61K8/33 ,  A61K8/34 ,  A61K8/342 ,  A61K8/37 ,  A61K2800/77 ,  A61Q13/00

    摘要： A skin barrier function recovery and promotion composition containing, as an active ingredient, a fragrance which is effective when evaluated by applying a predetermined stress to a model experimental animal, in a system to which the tested fragrance is not applied, to thereby reduce the skin barrier function of the animal and using this data of the degree of recovery of the skin barrier function as an indicator and evaluating the capability by the difference between this data and data of the degree of recovery of the skin barrier function in a system to which the tested fragrance is applied.

    摘要翻译： 一种皮肤屏障功能恢复和促进组合物，其包含作为有效成分的香料，其通过在模拟实验动物施加预定的压力，在未施用测试香料的系统中进行评估时有效，从而减少皮肤 使用该皮肤屏障功能恢复程度的数据作为指标，并且通过该数据与皮肤屏障功能的恢复程度的数据之间的差异来评估能力，所述系统中 测试香料。

    Method for visual imaging of ion distribution in tissue
    6.
    发明授权
    Method for visual imaging of ion distribution in tissue 有权
    组织中离子分布的视觉成像方法

    公开(公告)号：US06544794B1

    公开(公告)日：2003-04-08

    申请号：US09570447

    申请日：2000-05-12

    申请人： Mitsuhiro Denda

    发明人： Mitsuhiro Denda

    IPC分类号： G01A3700

    CPC分类号： G01N1/42 ,  G01N21/78 ,  Y10T436/13 ,  Y10T436/19

    摘要： A method is provided for producing a visual image of ions in a thin frozen tissue sample by placing the tissue sample in contact with a thin membrane having a water soluble gel or hydrophobic plastic thin film which has incorporated in or placed on its surface a fluorescent or color ion indicator which fluoresces or changes color under light of a particular wavelength. The thin frozen tissue sample is then subjected to light having a wavelength to cause the ion indicator to fluoresce or change color.

    摘要翻译： 提供了一种用于通过将组织样品与具有水溶性凝胶或疏水性塑料薄膜的薄膜接触来制造薄的冷冻组织样品中的离子的视觉图像的方法，所述薄膜具有掺入或放置在其表面上的荧光或 彩色离子指示剂，其在特定波长的光下发荧光或改变颜色。 然后将薄的冷冻组织样品经受具有波长的光，导致离子指示剂发荧光或改变颜色。

    Method for increasing oxytocin release in the epidermis
    7.
    发明授权
    Method for increasing oxytocin release in the epidermis 有权
    增加表皮中催产素释放的方法

    公开(公告)号：US08247382B2

    公开(公告)日：2012-08-21

    申请号：US12616908

    申请日：2009-11-12

    申请人： Sumiko Denda ,  Mitsuhiro Denda ,  Kazuyuki Ikeyama

    发明人： Sumiko Denda ,  Mitsuhiro Denda ,  Kazuyuki Ikeyama

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： A61K31/23 ,  A61K31/7072 ,  A61K31/7076

    摘要： A method for increasing oxytocin release through direct action on the epidermal keratinocytes is provided. The method for increasing oxytocin release in the epidermis includes increasing the calcium ion concentration in the epidermal cells. In the method of the present invention, the increase of the calcium ion concentration in the epidermal cells may be achieved by physically stimulating the skin. The physical stimulation may be achieved by applying a heat stimulus and/or a massage. The increase of the calcium ion concentration in the epidermal cells may be achieved by stimulating the epidermal cells by at least one agent selected from the group consisting of ATP, UTP, 4 alpha-phorbol 12,13-didecanoate, and pharmaceutically acceptable salts thereof.

    摘要翻译： 提供了通过对表皮角质形成细胞的直接作用增加催产素释放的方法。 增加表皮中催产素释放的方法包括增加表皮细胞中的钙离子浓度。 在本发明的方法中，表皮细胞中钙离子浓度的增加可以通过物理刺激皮肤来实现。 物理刺激可以通过施加热刺激和/或按摩来实现。 表皮细胞中钙离子浓度的增加可以通过至少一种选自ATP，UTP，4α-佛波醇12,13-十一酸酯的药剂及其药学上可接受的盐来刺激表皮细胞来实现。