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公开(公告)号：US5616691A
公开(公告)日：1997-04-01
申请号：US456484
申请日：1995-06-01
CPC分类号： C07K14/765
摘要： The process for producing the albumin preparation of the present invention comprises treating an aqueous albumin solution with an anion exchanger and a cation exchanger and subjecting the solution to heat treatment wherein a polyacrylamide type carrier having a cation exchange group is used as a cation exchanger. By using a polyacrylamide type carrier as a cation exchanger, the polymerization caused by the contaminating proteins can be suppressed, and a highly purified albumin preparation can be obtained.
摘要翻译： 本发明的白蛋白制剂的制造方法包括用阴离子交换剂和阳离子交换剂处理白蛋白水溶液，对该溶液进行热处理，其中使用具有阳离子交换基团的聚丙烯酰胺型载体作为阳离子交换剂。 通过使用聚丙烯酰胺型载体作为阳离子交换剂，可以抑制由污染蛋白质引起的聚合，并且可以获得高度纯化的白蛋白制剂。
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公开(公告)号：US07094948B2
公开(公告)日：2006-08-22
申请号：US10493943
申请日：2002-11-13
申请人： Akira Miyake , Yukihiro Nakamura , Jianwei Ni , Shinobu Mochizuki
发明人： Akira Miyake , Yukihiro Nakamura , Jianwei Ni , Shinobu Mochizuki
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C07K14/705 , C12N15/8509 , C12N2830/008
摘要： There is discloses a transgenic mouse over-expressing a potassium channel BEC1, which can be used as an effective tool for screening a substance for antidementia or a substance to improve learning and memory.Also disclosed are an in vivo screening method of a substance for antidementia or a substance to improve learning and memory, which uses the learning and memory abilities of said mouse as the index, and an in vivo screening of a substance for antianxiety, which uses acceleration of anxiety as the index.In addition, there is disclosed a method for producing a pharmaceutical composition for antidementia, learning and memory improvement use or antianxiety, using a substance capable of inhibiting the learning and memory potassium channel activity as the active ingredient which can be obtained by the aforementioned screening method of the present invention.
摘要翻译： 公开了一种过表达钾通道BEC1的转基因小鼠，其可以用作筛选用于抗痴呆的物质的有效工具或改善学习和记忆的物质。 还公开了用于抗痴呆的物质的体内筛选方法或改善学习和记忆的物质，其使用所述小鼠的学习和记忆能力作为指标，并且对使用加速度的抗焦虑物质进行体内筛选 的焦虑作为指标。 此外，公开了使用能够抑制学习和记忆钾通道活性的物质作为活性成分的能够通过上述筛选方法获得的抗痴呆，学习和记忆改善用途或抗焦虑药物组合物的制备方法 的本发明。
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公开(公告)号：US06828101B2
公开(公告)日：2004-12-07
申请号：US09965830
申请日：2001-10-01
申请人： Akira Miyake , Shinobu Mochizuki , Hiromichi Yokoi
发明人： Akira Miyake , Shinobu Mochizuki , Hiromichi Yokoi
IPC分类号： C12Q168
CPC分类号： C07K14/705
摘要： The present invention relates to a novel potassium channel protein expressed exclusively in the brain, a gene encoding this protein, a vector containing this gene, a host cell containing this vector, and so on. A typical method for obtaining the potassium channel protein of the present invention; mRNA is extracted from human cells or tissue capable of producing the potassium channel protein of the present invention. Then use is made of two primers between which the channel protein mRNA or a part of the mRNA region is located by using the thus extracted mRNA as a template. By carrying out a reverse transcriptase-polymerase chain reaction (to be referred to as RT-PCR hereinafter), the channel protein cDNA or a part thereof can be obtained. Thereafter, the channel protein can be produced by integrating the thus obtained novel potassium channel cDNA or a part of the same into an appropriate expression vector and then effecting its expression in a host cell.
摘要翻译： 本发明涉及一种仅在脑中表达的新型钾通道蛋白，编码该蛋白的基因，含该基因的载体，含有该载体的宿主细胞等。一种获得该蛋白的钾通道蛋白的典型方法 从能够产生本发明的钾通道蛋白质的人细胞或组织提取mRNA。 然后通过使用由此提取的mRNA作为模板，使用通道蛋白质mRNA或mRNA区域的一部分之间的两个引物。 通过进行逆转录聚合酶链反应（以下称为RT-PCR），可以获得通道蛋白cDNA或其一部分。 此后，通过将由此获得的新型钾通道cDNA或其一部分的cDNA整合到合适的表达载体中，然后在宿主细胞中表达，可以产生通道蛋白。
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公开(公告)号：US07476508B2
公开(公告)日：2009-01-13
申请号：US10542560
申请日：2004-01-16
申请人： Yorikata Sano , Kohei Inamura , Shinobu Mochizuki
发明人： Yorikata Sano , Kohei Inamura , Shinobu Mochizuki
IPC分类号： G01N33/53 , G01N33/566 , G01N33/48 , G01N31/00 , G01N25/18
CPC分类号： C07K14/705
摘要： A screening tool and a screening method of a substance which is useful as an agent for improving the memory, an agent for improving learning ability, and/or an antidementia agent; a polypeptide, a polynucleotide, a vector, and a cell which may be used in the above screening; and a novel agent for improving the memory, a novel agent for improving learning ability, and/or a novel antidementia agent are disclosed. The above screening tool is composed of a calcium-permeable nonselective cation channel or a cell expressing the channel.
摘要翻译： 可用作改善记忆的药剂的物质的筛选工具和筛选方法，提高学习能力的药剂和/或抗增殖剂; 可用于上述筛选的多肽，多核苷酸，载体和细胞; 和用于提高记忆力的新型药剂，提高学习能力的新型药剂和/或新型抗增殖剂。 上述筛选工具由钙渗透性非选择性阳离子通道或表达通道的细胞组成。
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公开(公告)号：US20080227785A1
公开(公告)日：2008-09-18
申请号：US12027246
申请日：2008-02-06
申请人： Hideki Kubota , Takeshi Suzuki , Masanori Miura , Eiichi Nakai , Kiyoshi Yahiro , Akira Miyake , Shinobu Mochizuki , Kazuhiro Nakatou
发明人： Hideki Kubota , Takeshi Suzuki , Masanori Miura , Eiichi Nakai , Kiyoshi Yahiro , Akira Miyake , Shinobu Mochizuki , Kazuhiro Nakatou
IPC分类号： A61K31/53
CPC分类号： C07D471/04 , A61K31/53 , C07D251/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D491/04
摘要： This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient.It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or therapeutic agent for diseases, preferably dementia, in which the BEC 1 potassium channel is considered to be concerned.Illustratively, it was confirmed by an in vivo test that the BEC 1 potassium channel inhibitor has an action to improve learning disorder.Also, it was found that a compound having 2,4,6-triamino-1,3,5-triazine has a BEC 1 potassium channel inhibitory action.
摘要翻译： 本发明涉及使用BEC 1钾通道抑制剂作为活性成分的抗痴呆药。 证明BEC 1钾通道抑制剂具有改善学习障碍的作用，可用作预防或治疗BEC 1钾通道所涉及的疾病，优选痴呆症。 说明性地，通过体内试验证实BEC 1钾通道抑制剂具有改善学习障碍的作用。 此外，发现具有2,4,6-三氨基-1,3,5-三嗪的化合物具有BEC 1钾通道抑制作用。
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公开(公告)号：US20060116315A1
公开(公告)日：2006-06-01
申请号：US10542560
申请日：2004-01-16
申请人： Yorikata Sano , Kohei Inamura , Shinobu Mochizuki
发明人： Yorikata Sano , Kohei Inamura , Shinobu Mochizuki
IPC分类号： A61K38/17 , C07K14/705 , G01N33/567
CPC分类号： C07K14/705
摘要： A screening tool and a screening method of a substance which is useful as an agent for improving the memory, an agent for improving learning ability, and/or an antidementia agent; a polypeptide, a polynucleotide, a vector, and a cell which may be used in the above screening; and a novel agent for improving the memory, a novel agent for improving learning ability, and/or a novel antidementia agent are disclosed. The above screening tool is composed of a calcium-permeable nonselective cation channel or a cell expressing the channel.
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公开(公告)号：US20090165196A1
公开(公告)日：2009-07-02
申请号：US12003815
申请日：2008-01-02
IPC分类号： E03D9/10
CPC分类号： A47K11/026 , Y02A50/454
摘要： A toilet apparatus is adapted to put the excrement produced each time by the user of the toilet into a bag to form a package of waste, treating the excrement into a state of combustible substance before putting it into a bag. The toilet apparatus is equipped with a long, flexible and folded continuous cylindrical member set in position below a toilet seat as packaging member that is adapted to receive the excrement produced by the user each time and become sealed and transferred downward in the toilet bowl, a processing material for absorbing liquid and semi-solidifying the excrement being arranged at a side of the toilet apparatus, a quantity of the processing material being fed into the packaging member for receiving the excrement each time of production of excrement so as to absorb liquid from the excrement, the packaging member being subsequently sealed at an opening thereof.
摘要翻译： 厕所装置适于将马桶使用者每次产生的排泄物放入袋中以形成废物包装，在将粪便放入袋中之前将其处理成可燃物质的状态。 厕所装置配备有一长的柔性和折叠的连续圆柱形构件，其设置在马桶座下方的位置，作为包装构件，其适于每次接收使用者产生的粪便并被密封并向下传送到马桶中， 用于吸收液体并将排泄物半固化的处理材料布置在马桶装置的一侧，每当生产排泄物时，将一定量的加工材料供给到用于接收排泄物的包装构件中，以便从其中吸收液体 排泄物，随后将包装构件的开口密封。
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公开(公告)号：US07264935B2
公开(公告)日：2007-09-04
申请号：US10506624
申请日：2003-07-31
申请人： Katsura Nozawa , Shinobu Mochizuki
发明人： Katsura Nozawa , Shinobu Mochizuki
IPC分类号： G01N33/53 , C12P21/02 , C12N5/10 , C07K14/435 , C07H21/00
CPC分类号： G01N33/6872 , C07K14/47 , G01N2500/00
摘要： A novel polypeptide, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, a cell transfected by the expression vector, a method for producing the polypeptide, and a convenient screening system for obtaining a substance useful in treating cell injuries due to postischemic reperfusion or an inflammatory disease, are disclosed.The polypeptide is a potassium-dependent sodium-calcium exchanger expressed in peripheral leukocytes.
摘要翻译： 新型多肽，编码多肽的多核苷酸，包含多核苷酸的表达载体，表达载体转染的细胞，多肽的制备方法以及用于获得用于治疗由于缺血再灌注引起的细胞损伤的物质的方便的筛选系统 或炎症性疾病。 多肽是在外周白细胞中表达的钾依赖性钠 - 钙交换体。
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公开(公告)号：US6024596A
公开(公告)日：2000-02-15
申请号：US17855
申请日：1998-02-03
CPC分类号： H01R23/661 , H01R4/029
摘要： A joint structure of a flat cable and joint terminals is provided. In this structure, bus bars are arranged in conformity with the arrangement pitch of the conductors. A bus bar holder is formed by securing the conforming side of the bus bars by a first bus bar resin layer formed of an insulating resin. The conductors are laminated and welded between terminal plates and bus bars held by the bus bar holder. An insulating coating layer of the flat cable is interposed between a first terminal resin layer and a first bus bar coating layer. The bus bar holder also includes a second bus bar resin layer formed of an insulating resin at the other side of the bus bars, and a tip coating layer remaining at the front edges of the conductors of the flat cable is interposed between the second terminal resin layer and the second bus bar resin layer. Furthermore, an insertion groove into which the tip coating layer is inserted is formed on the second bus bar resin layer or the second terminal resin layer. Thus, the connection region of the flat cable and joint terminals can be protected from pulling force.
摘要翻译： 提供扁平电缆和接头端子的接头结构。 在该结构中，母线与导体的排列间距一致。 通过由绝缘树脂形成的第一汇流条树脂层来固定母线的一致侧而形成汇流条支架。 导线被层压和焊接在端子板和汇流条座之间保持的母线之间。 扁平电缆的绝缘涂层插入在第一端子树脂层和第一母线涂层之间。 汇流条支架还包括在汇流条的另一侧由绝缘树脂形成的第二汇流条树脂层，并且在扁平电缆的导体的前边缘处保留的末端涂层保留在第二端子树脂 层和第二母线树脂层。 此外，在第二母线树脂层或第二端子树脂层上形成插入有尖端被覆层的插入槽。 因此，可以保护扁平电缆和接头端子的连接区域免受拉力的影响。
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公开(公告)号：US20050119173A1
公开(公告)日：2005-06-02
申请号：US10506624
申请日：2003-07-31
申请人： Katsura Nozawa , Shinobu Mochizuki
发明人： Katsura Nozawa , Shinobu Mochizuki
IPC分类号： A61P9/10 , A61P43/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/12 , G01N33/68 , G01N33/53 , A61K38/17 , C07H21/04 , C07K14/705 , G01N33/567
CPC分类号： G01N33/6872 , C07K14/47 , G01N2500/00
摘要： A novel polypeptide, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, a cell transfected by the expression vector, a method for producing the polypeptide, and a convenient screening system for obtaining a substance useful in treating cell injuries due to postischemic reperfusion or an inflammatory disease, are disclosed. The polypeptide is a potassium-dependent sodium-calcium exchanger expressed in peripheral leukocytes.
摘要翻译： 新型多肽，编码多肽的多核苷酸，包含多核苷酸的表达载体，表达载体转染的细胞，多肽的制备方法以及用于获得用于治疗由于缺血再灌注引起的细胞损伤的物质的方便的筛选系统 或炎症性疾病。 多肽是在外周白细胞中表达的钾依赖性钠 - 钙交换体。
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