公开(公告)号：US20180072801A1

公开(公告)日：2018-03-15

申请号：US15492782

申请日：2017-04-20

申请人： UCB PHARMA, S.A.

发明人： David G. Winkler ,  Jiye Shi ,  John Latham

IPC分类号： C07K16/22 ,  G01N33/68 ,  C07K14/475 ,  A61K47/64 ,  C07K16/18 ,  C07K14/51

CPC分类号： C07K16/22 ,  A61K47/643 ,  A61K47/646 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K2317/76 ,  G01N33/6854 ,  G01N2333/4704

摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

公开(公告)号：US11702468B2

公开(公告)日：2023-07-18

申请号：US16554510

申请日：2019-08-28

申请人： UCB Pharma, S.A.

发明人： David G. Winkler ,  Jiye Shi ,  John Latham

IPC分类号： G01N33/68 ,  G01N33/50 ,  G01N33/577 ,  C07K16/22 ,  C07K14/51 ,  C07K16/18 ,  A61K47/64 ,  C07K14/475

CPC分类号： C07K16/22 ,  A61K47/643 ,  A61K47/646 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  G01N33/6854 ,  C07K2317/76 ,  G01N33/50 ,  G01N33/577 ,  G01N33/68 ,  G01N33/6863 ,  G01N2333/4704

摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

公开(公告)号：US20160187357A1

公开(公告)日：2016-06-30

申请号：US14626274

申请日：2015-02-19

申请人： UCB PHARMA S.A.

发明人： Mary E. Brunkow ,  David J. Galas ,  Brian Kovacevich ,  John T. Mulligan ,  Bryan W. Paeper ,  Jeffrey Van Ness ,  David G. Winkler

IPC分类号： G01N33/74

CPC分类号： G01N33/74 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K16/22 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2319/00 ,  C12N2799/021 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N33/6872 ,  G01N33/84 ,  G01N2333/47 ,  G01N2333/495 ,  G01N2333/51 ,  G01N2500/02 ,  G01N2500/20

摘要： A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.

摘要翻译： 一种新型的TGF- 公开了结合蛋白。 还公开了用于选择用于增加骨矿化的分子的测定法和利用这种分子的方法。

公开(公告)号：US09791462B2

公开(公告)日：2017-10-17

申请号：US14626274

申请日：2015-02-19

申请人： UCB PHARMA S.A.

发明人： Mary E. Brunkow ,  David J. Galas ,  Brian Kovacevich ,  John T. Mulligan ,  Bryan W. Paeper ,  Jeffrey Van Ness ,  David G. Winkler

IPC分类号： G01N33/68 ,  G01N33/84 ,  C07K14/475 ,  A61K38/18 ,  A61K45/06 ,  G01N33/74 ,  C07K14/51 ,  C07K16/18 ,  C07K16/22 ,  C12Q1/68 ,  A61K39/395 ,  A61K48/00

CPC分类号： G01N33/74 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K16/22 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2319/00 ,  C12N2799/021 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N33/6872 ,  G01N33/84 ,  G01N2333/47 ,  G01N2333/495 ,  G01N2333/51 ,  G01N2500/02 ,  G01N2500/20

摘要： A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.

公开(公告)号：US09657095B2

公开(公告)日：2017-05-23

申请号：US14662538

申请日：2015-03-19

申请人： UCB PHARMA S.A.

发明人： David G. Winkler ,  Jiye Shi ,  John Latham

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K16/22 ,  C12N1/21 ,  C12N5/10 ,  C12N5/12 ,  C12N15/11 ,  C12N15/13 ,  C12N15/63 ,  C07K14/51 ,  A61K47/48 ,  C07K14/475 ,  G01N33/68

CPC分类号： C07K16/22 ,  A61K47/643 ,  A61K47/646 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K2317/76 ,  G01N33/6854 ,  G01N2333/4704

摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

公开(公告)号：US09011856B2

公开(公告)日：2015-04-21

申请号：US13670259

申请日：2012-11-06

申请人： UCB Pharma S.A.

发明人： David G. Winkler ,  Jiye Shi ,  John Latham

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53 ,  C07K16/22 ,  C07K14/51

CPC分类号： C07K16/22 ,  A61K47/643 ,  A61K47/646 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K2317/76 ,  G01N33/6854 ,  G01N2333/4704

摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

摘要翻译： 提供了与特异性结合TGF-β结合蛋白的抗体相关的组合物和方法。 这些方法和组合物涉及通过干扰TGF-β结合蛋白质硬化蛋白和TGF-β超家族成员，特别是骨形态发生蛋白之间的相互作用来改变骨矿物质密度。 增加骨矿物质密度在低骨矿物质密度代表骨质减少症，骨质疏松症和骨折等疾病和病症中具有应用价值。

公开(公告)号：US08992911B2

公开(公告)日：2015-03-31

申请号：US13670240

申请日：2012-11-06

申请人： UCB Pharma S.A.

发明人： David G. Winkler ,  Jiye Shi ,  John Latham

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K16/22 ,  C07K14/51

CPC分类号： C07K16/22 ,  A61K47/643 ,  A61K47/646 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K2317/76 ,  G01N33/6854 ,  G01N2333/4704

摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

公开(公告)号：US20240209075A1

公开(公告)日：2024-06-27

申请号：US18333425

申请日：2023-06-12

申请人： UCB PHARMA S.A.

发明人： David G. Winkler ,  Jiye Shi ,  John Latham

IPC分类号： C07K16/22 ,  A61K47/64 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  G01N33/50 ,  G01N33/577 ,  G01N33/68

CPC分类号： C07K16/22 ,  A61K47/643 ,  A61K47/646 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  G01N33/6854 ,  C07K2317/76 ,  G01N33/50 ,  G01N33/577 ,  G01N33/68 ,  G01N33/6863 ,  G01N2333/4704

摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

公开(公告)号：US08986685B2

公开(公告)日：2015-03-24

申请号：US13644728

申请日：2012-10-04

申请人： UCB Pharma S.A.

发明人： Mary E. Brunkow ,  David J. Galas ,  Brian Kovacevich ,  John T. Mulligan ,  Bryan W. Paeper ,  Jeffrey Van Ness ,  David G. Winkler

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12P21/08 ,  A61K45/06 ,  C07K14/51 ,  C07K16/22 ,  C12Q1/68 ,  G01N33/68 ,  A61K48/00

CPC分类号： G01N33/74 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K16/22 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2319/00 ,  C12N2799/021 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N33/6872 ,  G01N33/84 ,  G01N2333/47 ,  G01N2333/495 ,  G01N2333/51 ,  G01N2500/02 ,  G01N2500/20

摘要： Described herein are pharmaceutical compositions comprising an anti-sclerostin antibody and an inhibitor of bone resorption.

摘要翻译： 本文描述了包含抗硬化蛋白酶抗体和骨吸收抑制剂的药物组合物。

公开(公告)号：US20130267689A1

公开(公告)日：2013-10-10

申请号：US13849342

申请日：2013-03-22

申请人： UCB Pharma S.A.

发明人： John Latham ,  David G. Winkler

IPC分类号： C07K16/18

CPC分类号： C07K16/18 ,  C07K16/22 ,  C07K2317/56 ,  C07K2317/565

摘要： Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.

摘要翻译： 提供了与硬骨素结合剂（例如能够结合硬化蛋白的抗体和多肽）相关的组合物和方法。