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公开(公告)号:US20160175243A1
公开(公告)日:2016-06-23
申请号:US14591729
申请日:2015-01-07
Inventor: TANMAY P. LELE , FAN REN , BENJAMIN G. KESELOWSKY , JIYEON LEE , ANAND GUPTE , BYUNG-HWAN CHU , KARL R. ZAWOY
IPC: A61K9/00 , A61K38/02 , A61K31/366 , A61K33/24 , A61K38/48 , C01G9/02 , A61K31/407
CPC classification number: A61K9/00 , A61K31/366 , A61K31/407 , A61K33/24 , A61K38/02 , A61K38/4893 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01G9/02 , C01G23/047 , C01P2004/03 , C01P2004/16 , C01P2004/62 , C01P2004/64 , C12Y304/24069 , C30B7/10 , C30B29/16 , C30B29/60 , Y10S977/762 , Y10S977/915 , Y10T428/249924 , Y10T428/249925 , Y10T428/24994 , Y10T428/294 , Y10T428/2958 , Y10T428/2964 , Y10T428/298
Abstract: The subject invention concerns nanorods, compositions and substrates comprising nanorods, and methods of making and using nanorods and nanorod compositions and substrates. In one embodiment, the nanorod is composed of Zinc oxide (ZnO). In a further embodiment, a nanorod of the invention further comprises SiO2 or TiO2. In a specific embodiment, a nanorod of the invention is composed of ZnO coated with SiO2. Nanorods of the present invention are useful as an adhesion-resistant biomaterial capable of reducing viability in anchorage-dependent cells.
Abstract translation: 本发明涉及包含纳米棒的纳米棒,组合物和底物,以及制备和使用纳米棒和纳米棒组合物和底物的方法。 在一个实施方案中,纳米棒由氧化锌(ZnO)组成。 在另一个实施方案中,本发明的纳米棒还包含SiO 2或TiO 2。 在具体实施方案中,本发明的纳米棒由涂覆有SiO 2的ZnO组成。 本发明的纳米棒可用作能够降低锚定依赖性细胞活力的耐粘附生物材料。