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公开(公告)号：US10059722B2
公开(公告)日：2018-08-28
申请号：US14439373
申请日：2013-11-04
发明人： Jeffrey Aube , Carl Nathan , Robert Smith , Ben S. Gold , Paul Hanson , Chunjing Liu , Lester Allen Mitscher , Maneesh Pingle , Frank John Schoenen
IPC分类号： C07D501/60 , C07D501/16 , A61K31/545 , C07D499/44 , C07D277/06 , C07D417/12 , C07D513/04 , A61K45/06 , A61K31/426 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/431 , A61K31/4725 , A61K31/546
CPC分类号： C07D501/16 , A61K31/426 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/431 , A61K31/4725 , A61K31/545 , A61K31/546 , A61K45/06 , C07D277/06 , C07D417/12 , C07D499/44 , C07D513/04 , Y02A50/401 , Y02A50/402 , A61K2300/00
摘要： This invention provides cephalosporin derivatives for killing or inhibiting the spread of microorganisms such as non-replicating Mycobacterium tuberculosis and in the treatment of infectious disease.
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公开(公告)号：US20150322087A1
公开(公告)日：2015-11-12
申请号：US14439373
申请日：2013-11-04
发明人： Jeffrey Aube , Carl Nathan , Robert Smith , Ben S. Gold , Paul Hanson , Chunjing Liu , Lester Allen Mitscher , Maneesh Pingle , Frank John Schoenen
IPC分类号： C07D501/16 , A61K31/43 , C07D277/06 , A61K31/426 , A61K45/06 , A61K31/427 , C07D513/04 , A61K31/429 , A61K31/545 , A61K31/546 , C07D499/44 , C07D417/12
CPC分类号： C07D501/16 , A61K31/426 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/431 , A61K31/4725 , A61K31/545 , A61K31/546 , A61K45/06 , C07D277/06 , C07D417/12 , C07D499/44 , C07D513/04 , Y02A50/401 , Y02A50/402 , A61K2300/00
摘要： This invention provides cephalosporin derivatives for killing or inhibiting the spread of microorganisms such as non-replicating Mycobacterium tuberculosis and in the treatment of infectious disease.
摘要翻译： 本发明提供头孢菌素衍生物用于杀死或抑制微生物如非复制型结核分枝杆菌的扩散和用于治疗感染性疾病。
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公开(公告)号：US10954226B2
公开(公告)日：2021-03-23
申请号：US15768628
申请日：2016-10-17
申请人： CORNELL UNIVERSITY
发明人： Gang Lin , Carl Nathan , Pradeep K. Singh , Lei Shi , Laura Kirkman
IPC分类号： C07D413/12 , C07D237/22 , C07D261/18 , C07D213/81 , C07D231/12 , C07D233/70 , C07D209/42 , C07D215/48 , A61P33/06 , A61K39/39 , C07C237/22
摘要： The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R, R1-R5, k, m, n, and q are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders, infectious disease, or for providing immunosuppression for transplanted organs or tissues.
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公开(公告)号：US11202817B2
公开(公告)日：2021-12-21
申请号：US15504951
申请日：2015-08-12
申请人： CORNELL UNIVERSITY
发明人： Gang Lin , Carl Nathan , Pradeep K. Singh
IPC分类号： A61K38/05 , C07C271/22 , C07C311/19 , C07C237/06 , C07D261/18 , C07C237/12 , C07C237/22 , C07D209/18 , C07C311/14 , A61K31/165 , A61K31/42 , A61K38/02 , C07K5/06
摘要： The compounds of the present invention are represented by the following compounds having Formula I: where the substituents R1, R4, L, M, X, Y, and s are as defined herein. The compounds of the present invention are also represented by the following compounds having Formula (Ia), Formula (Ib), or Formula (Ic): where the substituents R1-R4, Rx, Ry, X, Y, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.
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公开(公告)号：US11732005B2
公开(公告)日：2023-08-22
申请号：US17521328
申请日：2021-11-08
发明人： Gang Lin , Carl Nathan , Wenhu Zhan , Trevor Morgan , Ryoma Hara , Toshihiro Imaeda , Rei Okamoto , Kenjiro Sato , Kazuyoshi Aso , Tzu-Tshin Wong , Michael A. Foley
IPC分类号： C07K5/062 , C07K5/02 , C07D235/14 , C07D235/10 , A61K38/00
CPC分类号： C07K5/06026 , C07D235/10 , C07D235/14 , C07K5/02 , A61K38/00
摘要： The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I′):
where the substituents R, R1, R3, R4, R, W, X, Y, Z, k, and m are as defined herein and
where the substituents R, R1, R2, R3, R4, X, Y, Z, and m are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.-
公开(公告)号：US12016896B2
公开(公告)日：2024-06-25
申请号：US17532285
申请日：2021-11-22
申请人： CORNELL UNIVERSITY
发明人： Gang Lin , Carl Nathan , Pradeep K. Singh
IPC分类号： A61K38/05 , A61K31/165 , A61K31/42 , A61K38/02 , C07C237/06 , C07C237/12 , C07C237/22 , C07C271/22 , C07C311/14 , C07C311/19 , C07D209/18 , C07D261/18 , C07K5/06
CPC分类号： A61K38/05 , A61K31/165 , A61K31/42 , A61K38/02 , C07C237/06 , C07C237/12 , C07C237/22 , C07C271/22 , C07C311/14 , C07C311/19 , C07D209/18 , C07D261/18 , C07K5/06 , C07C2601/02
摘要： The compounds of the present invention are represented by the following compounds having Formula I:
where the substituents R1, R4, L, M, X, Y, and s are as defined herein. The compounds of the present invention are also represented by the following compounds having Formula (Ia), Formula (Ib), or Formula (Ic):
where the substituents R1-R4, Rx, Ry, X, Y, and s are as defined herein.
These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.-
公开(公告)号：US11629141B2
公开(公告)日：2023-04-18
申请号：US17177729
申请日：2021-02-17
申请人： CORNELL UNIVERSITY
发明人： Gang Lin , Carl Nathan , Pradeep K. Singh , Lei Shi , Laura Kirkman
IPC分类号： C07D413/12 , A61K39/39 , A61P33/06 , C07C237/22 , C07D209/42 , C07D213/81 , C07D215/48 , C07D231/12 , C07D233/70 , C07D261/18
摘要： The compounds of the present invention are represented by the following compounds having Formula (I): where the substituents R, R1-R5, k, m, n, and q are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders, infectious disease, or for providing immunosuppression for transplanted organs or tissues.
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公开(公告)号：US11066397B2
公开(公告)日：2021-07-20
申请号：US15768628
申请日：2016-10-17
申请人： CORNELL UNIVERSITY
发明人： Gang Lin , Carl Nathan , Pradeep K. Singh , Lei Shi , Laura Kirkman
IPC分类号： C07D413/12 , C07D237/22 , C07D261/18 , C07D213/81 , C07D231/12 , C07D233/70 , C07D209/42 , C07D215/48 , A61P33/06 , A61K39/39 , C07C237/22
摘要： The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R, R1-R5, k, m, n, and q are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders, infectious disease, or for providing immunosuppression for transplanted organs or tissues.
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公开(公告)号：US09988421B2
公开(公告)日：2018-06-05
申请号：US15110000
申请日：2015-01-12
申请人： CORNELL UNIVERSITY
发明人： Gang Lin , Carl Nathan , Aihao Ding , Xiaojing Ma
CPC分类号： C07K5/06104 , A61K38/00 , C07K5/06026 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/06113 , C07K5/06139 , C07K5/06191 , C07K5/0806 , C07K5/0821
摘要： The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.
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公开(公告)号：USRE49816E1
公开(公告)日：2024-01-30
申请号：US16893086
申请日：2020-06-04
申请人： CORNELL UNIVERSITY
发明人： Gang Lin , Carl Nathan , Aihao Ding , Xiaojing Ma
IPC分类号： C07K5/072 , C07K5/078 , C07K5/062 , C07K5/097 , C07K5/083 , C07K5/06 , C07K5/068 , A61K38/00
CPC分类号： C07K5/06104 , C07K5/0606 , C07K5/06026 , C07K5/06069 , C07K5/06086 , C07K5/06113 , C07K5/06139 , C07K5/06191 , C07K5/0806 , C07K5/0821 , A61K38/00
摘要： The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.
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