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    SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME
    3.
    发明申请
    SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME 审中-公开

    公开(公告)号：US20170080001A1

    公开(公告)日：2017-03-23

    申请号：US15247539

    申请日：2016-08-25

    Applicant: Cornell University ,  Purdue Research Foundation ,  Coferon, Inc.

    Inventor： Francis Barany ,  Maneesh Pingle ,  Donald E. Bergstrom ,  Sarah F. Giardina ,  Lee Daniel Arnold

    IPC: A61K31/695

    Abstract: Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s). In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

    MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION THAT EMPLOY BIOORTHOGONAL CHEMISTRIES, AND METHODS OF USING SAME
    4.
    发明申请
    MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION THAT EMPLOY BIOORTHOGONAL CHEMISTRIES, AND METHODS OF USING SAME 审中-公开
    在使用生物化学化学的水溶液中多元化的单体及其使用方法

    公开(公告)号：US20150087043A1

    公开(公告)日：2015-03-26

    申请号：US14251551

    申请日：2014-04-11

    Applicant: Coferon, Inc. ,  Cornell University

    Inventor： Lee Daniel Arnold ,  Maneesh Pingle ,  Douglas S. Werner

    IPC: C07D417/14 ,  C07D417/12 ,  C12N1/20 ,  C12N9/99 ,  C07D239/42 ,  C07D491/052

    CPC classification number: C07D417/14 ,  A61K38/00 ,  C07D239/42 ,  C07D417/12 ,  C07D491/052 ,  C12N9/6424 ,  C12Y304/21059

    Abstract: Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

    Abstract translation: 本文描述的是当在水性介质中与一种，两种，三种或更多种其它单体接触时，能够形成生物有用的多聚体的单体。 在一个方面，这样的单体可以能够在水性介质（例如体内）中结合另一单体以形成多聚体（例如二聚体）。 考虑的单体可以包括配体部分，连接体元件和连接配体部分和连接体元件的连接器元件。 在水性介质中，这样预期的单体可以经由每个连接体元件连接在一起，因此可以基本上同时调节一种或多种生物分子，例如调节蛋白质上或不同蛋白质上的两个或多个结合结构域。

    ALPHA,BETA-UNSATURATED MONOMERS CAPABLE OF MULTIMERIZATION IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME
    5.
    发明申请
    ALPHA,BETA-UNSATURATED MONOMERS CAPABLE OF MULTIMERIZATION IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME 审中-公开
    ALPHA，可溶于水溶液的多元化的BETA不饱和单体及其使用方法

    公开(公告)号：US20150080570A1

    公开(公告)日：2015-03-19

    申请号：US14251028

    申请日：2014-04-11

    Applicant: Coferon, Inc. ,  Cornell University

    Inventor： Lee Daniel Arnold ,  Maneesh Pingle

    IPC: C07D417/06 ,  C07D263/06 ,  C07D413/06 ,  C07D239/10

    CPC classification number: C07D417/06 ,  C07D239/10 ,  C07D263/06 ,  C07D413/06

    Abstract: Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

    Abstract translation: 本文描述的是当在水性介质中与一种，两种，三种或更多种其它单体接触时，能够形成生物有用的多聚体的单体。 在一个方面，这样的单体可以能够在水性介质（例如体内）中结合另一单体以形成多聚体（例如二聚体）。 考虑的单体可以包括配体部分，连接体元件和连接配体部分和连接体元件的连接器元件。 在水性介质中，这样预期的单体可以经由每个连接体元件连接在一起，因此可以基本上同时调节一种或多种生物分子，例如调节蛋白质上或不同蛋白质上的两个或多个结合结构域。

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