公开(公告)号：US09771395B2

公开(公告)日：2017-09-26

申请号：US15120071

申请日：2015-03-20

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Merika Treants Koday ,  Deborah L. Fuller ,  Aaron Chevalier ,  Jorgen Nelson ,  David Baker

IPC: A61K38/00 ,  C07K14/00 ,  G01N33/569 ,  A61K9/00

CPC classification number: C07K14/00 ,  A61K9/0043 ,  A61K38/00 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/04

Abstract: Designed polypeptides having the amino acid sequence of SEQ ID NQ: 1 are described that bind with high affinity and selectivity to the influenza hemagglutinin protein, and which can be used for treating and/or limiting an influenza infection, as well as diagnosing an influenza infection and identifying candidate compounds for treating an influenza infection.

公开(公告)号：US11883488B2

公开(公告)日：2024-01-30

申请号：US17721554

申请日：2022-04-15

Applicant: UNIVERSITY OF WASHINGTON ,  ABACUS BIOSCIENCE, INC.

Inventor： Edward A. Clark ,  Deborah L. Fuller ,  Che-Leung Law ,  Amanda Mak

IPC: A61K39/12 ,  A61K39/29 ,  A61K39/00 ,  A61K39/39 ,  C07K16/28 ,  C12N7/00

CPC classification number: A61K39/292 ,  A61K39/001129 ,  A61K39/39 ,  C07K16/2896 ,  C12N7/00 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2319/00 ,  C12N2730/10134

Abstract: Provided herein are compositions of CD1280 binding proteins and a Hepatitis B virus core antigen (HBcAg) and/or a Hepatitis B virus E antigen (HBeAg), or antigenic fragments or mutants thereof, attached to the CD180 binding protein, and methods for using the compositions to treat or limit the development of hepatitis-B virus (HBV)-related disorders.

公开(公告)号：US11324819B2

公开(公告)日：2022-05-10

申请号：US16088386

申请日：2016-11-22

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Edward Clark ,  Deborah L. Fuller ,  Che-Leung Law ,  Amanda Mak

IPC: A61K39/00 ,  A61K39/29 ,  A61K39/39 ,  C07K16/28 ,  C12N7/00

Abstract: Provided herein are compositions of CD1280 binding proteins and a Hepatitis B virus core antigen (HBcAg) and/or a Hepatitis B virus E antigen (HBeAg), or antigenic fragments or mutants thereof, attached to the CD180 binding protein, and methods for using the compositions to treat or limit the development of hepatitis-B virus (HBV)-related disorders.

公开(公告)号：US10766929B2

公开(公告)日：2020-09-08

申请号：US16483865

申请日：2018-03-15

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David Baker ,  Aaron Arthur Chevalier ,  Gabriel Jacob Rocklin ,  Christopher David Bahl ,  Lance Joseph Stewart ,  Daniel Adriano Silva Manzano ,  Deborah L. Fuller ,  Merika Treants Koday ,  Jason Gilmore

IPC: A61K38/00 ,  C07K14/00 ,  A61P31/16 ,  C07K16/00 ,  G01N33/569

Abstract: Polypeptides that bind to viral hemagglotinin are disclosed and methods for their use in treating or limiting influenza infection, and diagnosing influenza infection.