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公开(公告)号：US12234572B2
公开(公告)日：2025-02-25
申请号：US17294807
申请日：2019-11-19
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Alfredo Quijano Rubio , Daniel Adriano Silva Manzano , David Baker , Umut Ulge , Marc Joseph Lajoie
Abstract: Conditionally active receptor agonists that, when activated, bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor a subunit (IL˜13 Rα) are disclosed, as are components of the conditionally active receptor agonists and methods for using the conditionally active receptor agonists.
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公开(公告)号：US12227553B2
公开(公告)日：2025-02-18
申请号：US18187639
申请日：2023-03-21
Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventor： Daniel Adriano Silva Manzano , Shawn Yu , Umut Ulge , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl Walkey
Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
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公开(公告)号：US11655278B2
公开(公告)日：2023-05-23
申请号：US17473731
申请日：2021-09-13
Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventor： Daniel Adriano Silva Manzano , Shawn Yu , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl Walkey , Umut Ulge
CPC classification number: C07K14/55 , A61K47/60 , A61K47/62 , C07K14/5406 , C07K14/5437 , C07K14/5443 , A61K38/00 , C07B2200/13 , C07K2319/30 , C07K2319/33 , C07K2319/74
Abstract: De novo designed polypeptides that bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
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公开(公告)号：US20200317744A1
公开(公告)日：2020-10-08
申请号：US16909185
申请日：2020-06-23
Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventor： Daniel Adriano Silva Manzano , Shawn Yu , Umut Ulge , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl WALKEY
Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
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公开(公告)号：US20240076342A1
公开(公告)日：2024-03-07
申请号：US18187639
申请日：2023-03-21
Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventor： Daniel Adriano Silva Manzano , Shawn Yu , Umut Ulge , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl Walkey , Alfredo Quijano Rubio , Kevin Jude , Brian Weitzner
CPC classification number: C07K14/55 , A61K47/60 , A61K47/62 , C07K14/5406 , C07K14/5437 , C07K14/5443 , A61K38/00
Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
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Patent Agency Ranking
公开(公告)号：US20200347109A1
公开(公告)日：2020-11-05
申请号：US16909210
申请日：2020-06-23
Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventor： Daniel Adriano Silva Manzano , Shawn Yu , Umut Ulge , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl Walkey , Alfredo Quijano Rubio , Brian Weitzner
Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγcheterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
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公开(公告)号：US20200339648A1
公开(公告)日：2020-10-29
申请号：US16905669
申请日：2020-06-18
Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventor： Daniel Adriano Silva Manzano , Shawn Yu , Umut Ulge , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl Walkey , Alfredo Quijano Rubio , Kevin Jude , Brian Weitzner
Abstract: De novo designed polypeptides that bind to IL-2 receptor βνc heterodimer (IL-2Rβνc), IL-4 receptor ανc heterodimer (IL-4Rανc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
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公开(公告)号：US20220235110A1
公开(公告)日：2022-07-28
申请号：US17698553
申请日：2022-03-18
Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventor： Daniel Adriano Silva Manzano , Shawn Yu , Umut Ulge , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl WALKEY
Abstract: De novo designed polypeptides that bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
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公开(公告)号：US11117944B2
公开(公告)日：2021-09-14
申请号：US16905669
申请日：2020-06-18
Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventor： Daniel Adriano Silva Manzano , Shawn Yu , Umut Ulge , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl Walkey , Alfredo Quijano Rubio , Brian Weitzner
Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
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公开(公告)号：US10766929B2
公开(公告)日：2020-09-08
申请号：US16483865
申请日：2018-03-15
Applicant: UNIVERSITY OF WASHINGTON
Inventor： David Baker , Aaron Arthur Chevalier , Gabriel Jacob Rocklin , Christopher David Bahl , Lance Joseph Stewart , Daniel Adriano Silva Manzano , Deborah L. Fuller , Merika Treants Koday , Jason Gilmore
IPC: A61K38/00 , C07K14/00 , A61P31/16 , C07K16/00 , G01N33/569
Abstract: Polypeptides that bind to viral hemagglotinin are disclosed and methods for their use in treating or limiting influenza infection, and diagnosing influenza infection.
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