公开(公告)号：US11732011B2

公开(公告)日：2023-08-22

申请号：US17523174

申请日：2021-11-10

Applicant: UNIVERSITY OF WASHINGTON ,  INSTITUTE FOR RESEARCH IN BIOMEDICINE

Inventor： Neil P. King ,  David Baker ,  Brooke Fiala ,  Lance Joseph Stewart ,  Laurent Perez ,  Antonio Lanzavecchia ,  Jessica Marcandalli

IPC: C12N7/00 ,  C12N1/15 ,  C12N15/45 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61P31/14 ,  B82Y5/00 ,  A61K39/00

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61P31/14 ,  B82Y5/00 ,  C12N7/00 ,  A61K2039/575 ,  C07K2319/735 ,  C12N2760/18022 ,  C12N2760/18322 ,  C12N2760/18522

Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

公开(公告)号：US10766929B2

公开(公告)日：2020-09-08

申请号：US16483865

申请日：2018-03-15

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David Baker ,  Aaron Arthur Chevalier ,  Gabriel Jacob Rocklin ,  Christopher David Bahl ,  Lance Joseph Stewart ,  Daniel Adriano Silva Manzano ,  Deborah L. Fuller ,  Merika Treants Koday ,  Jason Gilmore

IPC: A61K38/00 ,  C07K14/00 ,  A61P31/16 ,  C07K16/00 ,  G01N33/569

Abstract: Polypeptides that bind to viral hemagglotinin are disclosed and methods for their use in treating or limiting influenza infection, and diagnosing influenza infection.

公开(公告)号：US12275757B2

公开(公告)日：2025-04-15

申请号：US18337881

申请日：2023-06-20

Applicant: University of Washington ,  INSTITUTE FOR RESEARCH IN BIOMEDICINE

Inventor： Neil P. King ,  David Baker ,  Brooke Fiala ,  Lance Joseph Stewart ,  Laurent Perez ,  Antonio Lanzavecchia ,  Jessica Marcandalli ,  Jorge Fallas ,  Yang Hsia

IPC: A61K39/12 ,  A61K39/00 ,  A61K39/155 ,  A61K39/385 ,  A61P31/14 ,  B82Y5/00 ,  C07K14/005 ,  C12N7/00

Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructure; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

公开(公告)号：US11192926B2

公开(公告)日：2021-12-07

申请号：US16500331

申请日：2018-04-03

Applicant: UNIVERSITY OF WASHINGTON ,  INSTITUTE FOR RESEARCH IN BIOMEDICINE

Inventor： Neil P. King ,  David Baker ,  Brooke Nickerson ,  Lance Joseph Stewart ,  Laurent Perez ,  Antonio Lanzavecchia ,  Jessica Marcandalli

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61K39/385 ,  A61P31/14 ,  B82Y5/00 ,  C12N7/00

Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.