公开(公告)号：US20220349651A1

公开(公告)日：2022-11-03

申请号：US17245445

申请日：2021-04-30

Applicant: UPM-Kymmene Corporation

Inventor： Markus Nuopponen ,  Marjo Yliperttula ,  Arto Merivaara ,  Ossi Korhonen ,  Jacopo Zini ,  Elle Koivunotko ,  Lisa Chinello ,  Giulia Scapin ,  Anne Meriluoto ,  Lauri Paasonen

IPC: F26B5/06 ,  C12N5/00

Abstract: A method for freeze-drying a hydrogel composition is disclosed, the method comprising providing the hydrogel composition, wherein the hydrogel composition comprises cellulose nanofibrils and/or cellulose nanocrystals, at least one saccharide, at least one amino acid, and biologics; and freeze-drying the hydrogel composition, thereby obtaining a freeze-dried hydrogel composition.

公开(公告)号：US20170354944A1

公开(公告)日：2017-12-14

申请号：US15538515

申请日：2015-12-21

Applicant: UPM-Kymmene Corporation

Inventor： Markus Nuopponen ,  Isko Kajanto ,  Anne Meriluoto ,  Kari Luukko ,  Lauri Paasonen

IPC: B01J13/00 ,  D21H11/18 ,  C12N1/22 ,  C12N5/00 ,  D21H11/20

CPC classification number: B01J13/0069 ,  B01J13/0056 ,  C12N1/22 ,  C12N5/0018 ,  C12N2500/05 ,  C12N2500/34 ,  C12N2521/00 ,  C12N2533/78 ,  D21H11/18 ,  D21H11/20

Abstract: The invention relates to a method for reducing the viscosity of a nanofibrillar cellulose hydrogel, wherein the method comprises mixing a nanofibrillar cellulose hydrogel with an aqueous growth medium for cell culture, wherein the aqueous growth medium contains one or more salts and optionally one or more sugars, using shearing forces so that a homogeneous dispersion is formed. The invention further relates to a dispersion comprising a nanofibrillar cellulose hydrogel and an aqueous growth medium for cell culture and to a use of an aqueous growth medium.

公开(公告)号：US11744798B2

公开(公告)日：2023-09-05

申请号：US17015415

申请日：2020-09-09

Applicant: UPM-Kymmene Corporation

Inventor： Markus Nuopponen ,  Lauri Paasonen ,  Anne Meriluoto ,  Jukka Rissanen ,  Harri Jukarainen

IPC: A61K9/06 ,  A61P25/04 ,  A61K9/00 ,  A61K31/403 ,  A61K31/4152 ,  A61K31/485 ,  A61K31/541 ,  A61K47/20 ,  A61K47/22 ,  A61K47/38

CPC classification number: A61K9/06 ,  A61K9/0019 ,  A61K31/403 ,  A61K31/4152 ,  A61K31/485 ,  A61K31/541 ,  A61K47/20 ,  A61K47/22 ,  A61K47/38 ,  A61P25/04

Abstract: An injectable pharmaceutical formulation includes nanofibrillar cellulose hydrogel wherein the content of nanofibrillar cellulose in the pharmaceutical formulation is the range of 1-8% (w/w), and pharmaceutical compound. The injectable pharmaceutical formulation can provide a sustained release of a pharmaceutical compound in a subject. Use of nanofibrillar cellulose for preparing the injectable pharmaceutical formulation is also disclosed.

公开(公告)号：US11014831B2

公开(公告)日：2021-05-25

申请号：US15571021

申请日：2016-05-04

Applicant: UPM-KYMMENE CORPORATION

Inventor： Helinä Hartikainen ,  Salla Venäläinen ,  Markus Nuopponen ,  Anne Meriluoto

IPC: C02F1/28 ,  B01J20/24 ,  C02F1/38 ,  C08B11/12 ,  B01J20/28 ,  C08L1/28 ,  C08L1/02 ,  C02F1/52 ,  C02F101/10 ,  C02F101/20

Abstract: The present invention concerns a process for removing metal ions from waste water, which process comprises providing plant-derived anionic nanofibrillar cellulose, carrying out a purification treatment comprising sorption of positively charged metal ions contained in the waste water to said nanofibrillar cellulose, separating used plant-derived anionic nanofibrillar cellulose from the waste water, and recovering treated waste water. The invention also concerns use of plant-derived anionic nanofibrillar cellulose for removing metal ions from waste water.

公开(公告)号：US10307722B2

公开(公告)日：2019-06-04

申请号：US15538515

申请日：2015-12-21

Applicant: UPM-Kymmene Corporation

Inventor： Markus Nuopponen ,  Isko Kajanto ,  Anne Meriluoto ,  Kari Luukko ,  Lauri Paasonen

IPC: C12N1/22 ,  D21H11/18 ,  D21H11/20 ,  B01J13/00 ,  C12N5/00

Abstract: The invention relates to a method for reducing the viscosity of a nanofibrillar cellulose hydrogel, wherein the method comprises mixing a nanofibrillar cellulose hydrogel with an aqueous growth medium for cell culture, wherein the aqueous growth medium contains one or more salts and optionally one or more sugars, using shearing forces so that a homogeneous dispersion is formed. The invention further relates to a dispersion comprising a nanofibrillar cellulose hydrogel and an aqueous growth medium for cell culture and to a use of an aqueous growth medium.

公开(公告)号：US20190031533A1

公开(公告)日：2019-01-31

申请号：US15571021

申请日：2016-05-04

Applicant: UPM-KYMMENE CORPORATION

Inventor： Helinä Hartikainen ,  Salla Venäläinen ,  Markus Nuopponen ,  Anne Meriluoto

IPC: C02F1/28 ,  C02F1/38 ,  B01J20/24 ,  B01J20/28 ,  C08B11/12

Abstract: The present invention concerns a process for removing metal ions from waste water, which process comprises providing plant-derived anionic nanofibrillar cellulose, carrying out a purification treatment comprising sorption of positively charged metal ions contained in the waste water to said nanofibrillar cellulose, separating used plant-derived anionic nanofibrillar cellulose from the waste water, and recovering treated waste water. The invention also concerns use of plant-derived anionic nanofibrillar cellulose for removing metal ions from waste water.