公开(公告)号：US20180015070A1

公开(公告)日：2018-01-18

申请号：US15643329

申请日：2017-07-06

申请人： USANA Health Sciences, Inc.

发明人： Mark Brown ,  John Cuomo ,  Jeremy Tian

IPC分类号： A61K31/385 ,  A61K31/714 ,  A61K31/7048 ,  A61K31/593 ,  A61K31/525 ,  A61K31/519 ,  A61K31/51 ,  A61K31/455 ,  A61K31/4415 ,  A61K31/4188 ,  A61K31/375 ,  A61K31/355 ,  A61K31/353 ,  A61K31/232 ,  A61K31/197 ,  A61K31/14 ,  A61K31/122 ,  A61K31/12 ,  A61K31/05 ,  A61K31/047 ,  A61K31/015 ,  A61K31/01 ,  A61K9/20 ,  A61K36/63 ,  A61K36/82

CPC分类号： A61K31/385 ,  A23L33/10 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/20 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/01 ,  A61K31/015 ,  A61K31/047 ,  A61K31/05 ,  A61K31/065 ,  A61K31/12 ,  A61K31/122 ,  A61K31/14 ,  A61K31/197 ,  A61K31/232 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/375 ,  A61K31/382 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/593 ,  A61K31/7048 ,  A61K31/714 ,  A61K36/63 ,  A61K36/82 ,  A61K45/06 ,  A61K47/551 ,  A61K2300/00 ,  A23V2200/30 ,  A23V2250/02 ,  A23V2250/032 ,  A23V2250/156 ,  A23V2250/1578 ,  A23V2250/161 ,  A23V2250/1642 ,  A23V2250/18 ,  A23V2250/2112 ,  A23V2250/21164 ,  A23V2250/21168 ,  A23V2250/2117 ,  A23V2250/213 ,  A23V2250/2131 ,  A23V2250/314 ,  A23V2250/641 ,  A23V2250/70 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/712 ,  A23V2250/714

摘要： A nutritional supplement for reducing free radical damage is disclosed. The nutritional supplement includes a first vehicle comprising an upregulating compound mixture configured to upregulate an endogenous antioxidant system and an exogenous antioxidant mixture and a second vehicle comprising a mineral mixture. The upregulating compound mixture is configured to upregulate an endogenous antioxidant system to protect against free radical damage. The upregulating compound mixture includes alpha lipoic acid, resveratrol, curcumin, EGCG, Olivol®, rutin, quercetin, and hesperetin. The endogenous antioxidant system includes transcription factors such as Nrf2, NF-κB, PPARα, PPARβ/δ, and PPARγ that promote transcription of antioxidant genes.

公开(公告)号：US20180008573A1

公开(公告)日：2018-01-11

申请号：US15643383

申请日：2017-07-06

申请人： USANA Health Sciences, Inc.

发明人： Mark Brown ,  John Cuomo ,  Jeremy Tian

IPC分类号： A61K31/385 ,  A61K31/714 ,  A61K31/7048 ,  A61K31/593 ,  A61K31/525 ,  A61K31/519 ,  A61K31/51 ,  A61K31/455 ,  A61K31/4415 ,  A61K31/4188 ,  A61K31/375 ,  A61K31/355 ,  A61K31/353 ,  A61K31/232 ,  A61K31/197 ,  A61K31/14 ,  A61K31/122 ,  A61K31/12 ,  A61K31/05 ,  A61K31/047 ,  A61K31/015 ,  A61K31/01 ,  A61K9/20 ,  A61K36/63 ,  A61K36/82

CPC分类号： A61K31/385 ,  A23L33/10 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/20 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/01 ,  A61K31/015 ,  A61K31/047 ,  A61K31/05 ,  A61K31/065 ,  A61K31/12 ,  A61K31/122 ,  A61K31/14 ,  A61K31/197 ,  A61K31/232 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/375 ,  A61K31/382 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/593 ,  A61K31/7048 ,  A61K31/714 ,  A61K36/63 ,  A61K36/82 ,  A61K45/06 ,  A61K47/551 ,  A61K2300/00 ,  A23V2200/30 ,  A23V2250/02 ,  A23V2250/032 ,  A23V2250/156 ,  A23V2250/1578 ,  A23V2250/161 ,  A23V2250/1642 ,  A23V2250/18 ,  A23V2250/2112 ,  A23V2250/21164 ,  A23V2250/21168 ,  A23V2250/2117 ,  A23V2250/213 ,  A23V2250/2131 ,  A23V2250/314 ,  A23V2250/641 ,  A23V2250/70 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/712 ,  A23V2250/714

摘要： A composition for reducing damage associated with oxidative phosphorylation. The composition comprises an upregulating compound mixture configured to upregulate an endogenous antioxidant system, an exogenous antioxidant mixture configured to inhibit oxidation of biomolecules by reactive oxygen species, and a mineral mixture configured to provide one or more cofactors to a endogenous antioxidant enzyme. The endogenous antioxidant system includes a Nrf2 transcription factors that promotes transcription of antioxidant genes.

公开(公告)号：US20180007945A1

公开(公告)日：2018-01-11

申请号：US15643396

申请日：2017-07-06

申请人： USANA Health Sciences, Inc.

发明人： Mark Brown ,  John Cuomo ,  Jeremy Tian

IPC分类号： A23L33/15 ,  A61K47/55 ,  A23L33/16

CPC分类号： A61K31/385 ,  A23L33/10 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/20 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/01 ,  A61K31/015 ,  A61K31/047 ,  A61K31/05 ,  A61K31/065 ,  A61K31/12 ,  A61K31/122 ,  A61K31/14 ,  A61K31/197 ,  A61K31/232 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/375 ,  A61K31/382 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/593 ,  A61K31/7048 ,  A61K31/714 ,  A61K36/63 ,  A61K36/82 ,  A61K45/06 ,  A61K47/551 ,  A61K2300/00 ,  A23V2200/30 ,  A23V2250/02 ,  A23V2250/032 ,  A23V2250/156 ,  A23V2250/1578 ,  A23V2250/161 ,  A23V2250/1642 ,  A23V2250/18 ,  A23V2250/2112 ,  A23V2250/21164 ,  A23V2250/21168 ,  A23V2250/2117 ,  A23V2250/213 ,  A23V2250/2131 ,  A23V2250/314 ,  A23V2250/641 ,  A23V2250/70 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/712 ,  A23V2250/714

摘要： A composition for supporting endogenous systems related to life span, inhibiting mTOR, and reducing damage associated with oxidative phosphorylation. The composition comprises an upregulating compound mixture configured to upregulate an endogenous antioxidant system, an exogenous antioxidant mixture configured to inhibit oxidation of biomolecules by reactive oxygen species, and a mineral mixture configured to provide one or more cofactors to a endogenous antioxidant enzyme. The endogenous antioxidant system includes regulation of mitophagy through mTOR mediated regulation, and a Nrf2 transcription factors that promotes transcription of antioxidant genes.