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    Methods for Selection of Subjects for Multiple Sclerosis Therapy
    4.
    发明申请
    Methods for Selection of Subjects for Multiple Sclerosis Therapy 审中-公开
    多发性硬化症治疗方法选择

    公开(公告)号：US20070237717A1

    公开(公告)日：2007-10-11

    申请号：US11578207

    申请日：2004-04-05

    申请人： Roland Martin ,  Louis Staudt ,  Henry McFarland ,  Claus-Steffen Sturzebecher

    发明人： Roland Martin ,  Louis Staudt ,  Henry McFarland ,  Claus-Steffen Sturzebecher

    IPC分类号： A61K49/00 ,  C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158

    摘要： A variety of therapies are used to treat autoimmune diseases such as multiple sclerosis. However, there is no single therapy that can be used to treat all subjects. Thus, a method is provided to determine if a subject with an autoimmune disease, such as multiple sclerosis, will respond to a therapeutic protocol. The method includes analyzing the expression of genes expressed by the immune system. Although the expression of a single gene can be assessed, such as interleukin-8, the methods include evaluating the expression profile of a subject using an array (such as a microarray) to determine if the subject is appropriately responding to the therapeutic protocol.

    摘要翻译： 多种疗法用于治疗多发性硬化症等自身免疫性疾病。 然而，没有一种可用于治疗所有受试者的治疗方法。 因此，提供了一种方法来确定具有自身免疫性疾病如多发性硬化的受试者是否将对治疗方案作出反应。 该方法包括分析由免疫系统表达的基因的表达。 虽然可以评估单一基因的表达，例如白介素-8，但是所述方法包括使用阵列（例如微阵列）评估受试者的表达谱以确定受试者是否适当地响应于治疗方案。

    Device for indicating the total load in the case of brake disks made of carbon-fiber-reinforced ceramic material
    5.
    发明授权
    Device for indicating the total load in the case of brake disks made of carbon-fiber-reinforced ceramic material 有权
    在由碳纤维增强陶瓷材料制成的制动盘的情况下指示总负载的装置

    公开(公告)号：US06776265B2

    公开(公告)日：2004-08-17

    申请号：US10101208

    申请日：2002-03-20

    申请人： Roland Martin

    发明人： Roland Martin

    IPC分类号： F16D6600

    CPC分类号： F16D66/02 ,  F16D65/12 ,  F16D2065/1328 ,  F16D2200/0039

    摘要： A device can indicate the total load of a brake disk made of carbon-fiber-reinforced ceramic material. In order to create such a device, which can be used for brake disks and other friction elements made of carbon-fiber-reinforced ceramic material, an indicator element can be provided in the brake disk starting from the friction surface. The oxidation stability of this indicator element is reduced with respect to the material of the brake disk.

    摘要翻译： 装置可以指示由碳纤维增强的陶瓷材料制成的制动盘的总负载。 为了制造可用于制动盘和由碳纤维增强陶瓷材料制成的其它摩擦元件的这种装置，可以从摩擦表面开始在制动盘中设置指示元件。 相对于制动盘的材料，该指示元件的氧化稳定性降低。

    Use of ectoine or ectoine derivatives in cosmetic formulations
    6.
    发明授权
    Use of ectoine or ectoine derivatives in cosmetic formulations 有权
    ectoine或ectoine衍生物在化妆品配方中的应用

    公开(公告)号：US06602514B1

    公开(公告)日：2003-08-05

    申请号：US09744945

    申请日：2001-01-31

    申请人： Joachim Bünger ,  Hans-Jürgen Driller ,  Roland Martin

    发明人： Joachim Bünger ,  Hans-Jürgen Driller ,  Roland Martin

    IPC分类号： A61K742

    CPC分类号： A61Q19/007 ,  A61K8/4953 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00

    摘要： The use of one or more compounds chosen from the compounds of the formulae Ia and Ib the physiologically compatible salts of the compounds of the formulae Ia and Ib and the stereoisomeric forms of the compounds of the formulae Ia and Ib, where R1, R2, R3, R4 and n have the meanings given in claim 1, for the preparation of a cosmetic formulation is advantageously suitable, e.g., for protecting cells, proteins and/or biomembranes of the human skin, for protecting the microflora of the human skin, and/or for stabilizing the skin barrier.

    摘要翻译： 使用一种或多种选自式Ia和Ib化合物的化合物是式Ia和Ib化合物的生理上相容的盐和式Ia和Ib化合物的立体异构形式，其中R1，R2，R3， R4和n具有权利要求1中给出的含义，对于化妆品制剂的制备有利地适合于例如用于保护人皮肤的细胞，蛋白质和/或生物膜，用于保护人皮肤的微生物群落和/或 用于稳定皮肤屏障。

    Process and device for machining by electroerosion
    8.
    发明授权
    Process and device for machining by electroerosion 有权
    电腐蚀加工工艺及装置

    公开(公告)号：US06392183B1

    公开(公告)日：2002-05-21

    申请号：US09599780

    申请日：2000-06-21

    申请人： Roland Martin ,  Aldo Gamboni ,  Maurizio Tognolini ,  Gilbert Bovay

    发明人： Roland Martin ,  Aldo Gamboni ,  Maurizio Tognolini ,  Gilbert Bovay

    IPC分类号： B23H102

    CPC分类号： B23H1/022 ,  B23H2300/20

    摘要： In the process of machining by electroerosion, there is adjusted during a first transitory phase the machining current increase of the discharges after triggering a discharge between the electrode and the piece, such that a parameter connected to this increase will be substantially equal to a reference value corresponding to a minimum wear value of the electrode. Then, the machining current is maintained during a second phase at a reference value. The adjustment is carried out by acting on the adjustable internal voltage of a low impedance adjustable voltage source connected between the electrode and the piece. The adjustment can be carried out by a servo control loop with a regulator of the internal voltage, a device for generating discharges, parts adapted to determine the slope of increase of the current of a discharge, a member determining the mean slope of N discharges and a member adapted to compute the difference between the mean slope and a pre-established reference slope.

    摘要翻译： 在通过电蚀加工的过程中，在第一暂态阶段中调整在触发电极和片之间的放电之后放电的加工电流增加，使得与该增加相关联的参数将基本上等于参考值 对应于电极的最小磨损值。 然后，在参考值的第二阶段期间维持加工电流。 通过作用在连接在电极和片之间的低阻抗可调电压源的可调内部电压来进行调整。 该调节可以通过具有内部电压调节器的伺服控制回路，用于产生放电的装置，适于确定放电电流的增加的斜率的部件，确定N次放电的平均斜率的部件，以及 适于计算平均斜率与预先建立的参考斜率之间的差异的构件。

    Brake disk made of a fiber-reinforced material
    9.
    发明授权
    Brake disk made of a fiber-reinforced material 有权
    由纤维增强材料制成的制动盘

    公开(公告)号：US06386341B1

    公开(公告)日：2002-05-14

    申请号：US09583578

    申请日：2000-05-31

    申请人： Roland Martin

    发明人： Roland Martin

    IPC分类号： F16D6512

    CPC分类号： F16D65/12 ,  F16D2065/1316 ,  F16D2065/132 ,  F16D2065/1324 ,  F16D2065/1328 ,  F16D2065/1392 ,  F16D2069/004 ,  F16D2200/0039 ,  F16D2200/0052 ,  F16D2200/006

    摘要： A brake disk made of a fiber-reinforced material includes two assembled friction rings. The friction rings, on interior sides, are provided with ribs. The two friction rings are supported with respect to one another along at least a portion of the ribs. In order to provide a suitable shaping of faces of the ribs, faces used as coupling faces are constructed such that a coupling of the friction rings is caused in precisely one rotating direction and, in a particular case, such that the coupling faces are arranged in an alternating manner.

    摘要翻译： 由纤维增强材料制成的制动盘包括两个组装的摩擦环。 在内侧的摩擦环设有肋。 两个摩擦环沿着肋的至少一部分相对于彼此支撑。 为了提供肋的面的适当成形，用作连接面的面被构造成使得摩擦环的联接在精确的一个旋转方向上产生，并且在特定情况下，使得联接面布置在 交替的方式。

    Braking device
    10.
    发明授权
    Braking device 失效
    制动装置

    公开(公告)号：US06186286B1

    公开(公告)日：2001-02-13

    申请号：US09210893

    申请日：1998-12-16

    申请人： Harald Häussler ,  Helmut Pietsch ,  Roland Martin ,  Carsten-Jörg Mertens ,  Artur Grunwald ,  Thomas Klaas ,  Michael Pehle ,  Reinhold Pittius

    发明人： Harald Häussler ,  Helmut Pietsch ,  Roland Martin ,  Carsten-Jörg Mertens ,  Artur Grunwald ,  Thomas Klaas ,  Michael Pehle ,  Reinhold Pittius

    IPC分类号： F16D5508

    CPC分类号： F16D65/092 ,  F16D55/38 ,  F16D65/183 ,  F16D2055/0008 ,  F16D2055/0016 ,  F16D2055/0062 ,  F16D2065/1368 ,  F16D2121/14 ,  F16D2125/40 ,  F16D2125/70

    摘要： A braking device for wheels of vehicles such as trailers includes a caliper in which brake linings are guided. Between these linings, at least one brake disk is displaceably held on driving toothing of a wheel hub. A pneumatically operable mechanical adjusting device interacts with the brake linings. The braking device includes at least one brake disk in a caliper which is fixed. On one end, the caliper is connected by a fastening element with an axle element of the vehicle. On the caliper, an enclosing housing for bearing the adjusting device is held. By way of a bearing plate, the adjusting device is also supported on the caliper. Pressure pistons of the device are guided by a one-part yoke in a jointly axially adjustable manner and can be acted upon by pressure with respect to the brake linings and the brake disks.

    摘要翻译： 用于诸如拖车的车辆的车轮的制动装置包括其中制动衬片被引导的卡钳。 在这些内衬之间，至少一个制动盘可移动地保持在轮毂的驱动齿上。 气动可操作的机械调节装置与制动衬片相互作用。 制动装置包括至少一个固定的制动盘。 一方面，卡钳通过具有车辆的轴元件的紧固元件连接。 在卡钳上，保持用于承载调节装置的封闭壳体。 通过支承板，调节装置也支撑在卡钳上。 装置的压力活塞由共同轴向调节的一个部分的轭引导，并且可以相对于制动衬片和制动盘的压力作用。