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    DUAL SAMPLE CARTRIDGE AND METHOD FOR CHARACTERIZING PARTICLES IN LIQUID
    1.
    发明申请
    DUAL SAMPLE CARTRIDGE AND METHOD FOR CHARACTERIZING PARTICLES IN LIQUID 有权
    双样品盒和液体中颗粒表征的方法

    公开(公告)号：US20110318774A1

    公开(公告)日：2011-12-29

    申请号：US13226683

    申请日：2011-09-07

    Applicant: Ulrik Darling Larsen

    Inventor： Ulrik Darling Larsen

    IPC: C12Q1/02

    CPC classification number: G01N15/12 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N1/38 ,  G01N35/1097 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1062

    Abstract: The present invention relates to an apparatus for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. Furthermore, the present invention relates to a method for characterizing particles in liquid and a device for sampling a small and accurate volume of liquid. The apparatus comprises a housing having a mixing chamber and a collection chamber separated by a wall containing an opening, a first bore in the outer surface of the housing for entrance of a liquid sample, a first cavity for receiving and holding a first liquid sample, and a second cavity for receiving and holding a second liquid sample.

    Abstract translation: 本发明涉及用于表征悬浮在液体中的颗粒的装置，特别是用于一次使用分析的独立一次性盒，例如用于少量全血的一次性分析。 此外，本发明涉及用于表征液体中的颗粒的方法以及用于对小量和精确体积的液体进行取样的装置。 该装置包括具有混合室和由包含开口的壁分离的收集室的壳体，用于引入液体样品的壳体外表面中的第一孔，用于接收和保持第一液体样品的第一腔， 以及用于接收和保持第二液体样品的第二腔。

    Method for calibrating a particle counting apparatus
    2.
    发明授权
    Method for calibrating a particle counting apparatus 有权
    校准粒子计数装置的方法

    公开(公告)号：US07928718B2

    公开(公告)日：2011-04-19

    申请号：US11664170

    申请日：2005-09-30

    Applicant: Ulrik Darling Larsen

    Inventor： Ulrik Darling Larsen

    IPC: G01N27/00 ,  G06M11/02

    CPC classification number: G01N15/1227

    Abstract: A method of calibration of a particle characterization apparatus, and a particle characterization apparatus, in which particles suspended in a liquid are passed through an orifice one by one for characterization of the particles, for instance by Coulter counting. The calibration does not require utilization of special calibration particles or liquids. A priori knowledge of the shape of a typical size distribution of a blood sample is utilized to adjust the apparatus based on an initial relatively short counting period of the sample in question. The initially determined size distribution is compared to the corresponding known typical size distribution and the apparatus is subsequently adjusted to counteract possible differences. Upon adjustment of the apparatus, the remaining part of the sample is passed through the orifice for determination of the actual particle size distribution of the remaining sample.

    Abstract translation: 颗粒表征装置的校准方法和颗粒表征装置，其中悬浮在液体中的颗粒逐个通过孔口，用于表征颗粒，例如通过库尔特计数。 校准不需要使用特殊的校准颗粒或液体。 利用血液样本的典型尺寸分布的形状的先验知识来基于所讨论的样品的初始相对较短的计数周期来调节装置。 将初始确定的尺寸分布与相应的已知典型尺寸分布进行比较，随后调整该装置以抵消可能的差异。 在调节设备时，将剩余部分样品通过孔口，以确定剩余样品的实际粒度分布。

    Dual sample cartridge and method for characterizing particles in liquid
    4.
    发明授权
    Dual sample cartridge and method for characterizing particles in liquid 有权
    双重样品盒和用于表征液体中的颗粒的方法

    公开(公告)号：US08028566B2

    公开(公告)日：2011-10-04

    申请号：US11815884

    申请日：2006-02-10

    Applicant: Ulrik Darling Larsen

    Inventor： Ulrik Darling Larsen

    IPC: G01N15/06

    CPC classification number: G01N15/12 ,  G01N33/49

    Abstract: The present invention relates to an apparatus for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. Furthermore, the present invention relates to a method for characterizing particles in liquid and a device for sampling a small and accurate volume of liquid. The apparatus comprises a housing having a mixing chamber and a collection chamber separated by a wall containing an opening, a first bore in the outer surface of the housing for entrance of a liquid sample, a first cavity for receiving and holding a first liquid sample, and a second cavity for receiving and holding a second liquid sample.

    Abstract translation: 本发明涉及用于表征悬浮在液体中的颗粒的装置，特别是用于一次使用分析的独立一次性盒，例如用于少量全血的一次性分析。 此外，本发明涉及用于表征液体中的颗粒的方法以及用于对小量和精确体积的液体进行取样的装置。 该装置包括具有混合室和由包含开口的壁分离的收集室的壳体，用于引入液体样品的壳体外表面中的第一孔，用于接收和保持第一液体样品的第一腔， 以及用于接收和保持第二液体样品的第二腔。

    HIGH RESOLUTION CLASSIFICATION
    5.
    发明申请
    HIGH RESOLUTION CLASSIFICATION 审中-公开
    高分辨率分类

    公开(公告)号：US20110027825A1

    公开(公告)日：2011-02-03

    申请号：US12918860

    申请日：2009-03-02

    Applicant: Ulrik Darling Larsen

    Inventor： Ulrik Darling Larsen

    IPC: C12Q1/06

    CPC classification number: G01N15/1227

    Abstract: The present invention relates to a method of determining pulse height distribution by using an apparatus comprising: an analogue to digital pulses height categorisation unit comparing the pulse to analogue threshold voltages and counting each event within each pulse height category using a micro controller. The method may comprise the steps of i) selecting a first set of threshold voltages, ii) performing a first measurement using the first set of threshold voltages, iii) selecting a new set of threshold voltages different from the first set of threshold voltages, iv) performing a new measurement using the new set of threshold voltages, v) determining cell size distribution based on the first measurement and the new measurement. The present invention further relates to an apparatus comprising an analogue to digital pulses height categorisation unit comparing the pulse to analogue threshold voltages, a micro controller configured for counting each event within each pulse height category, the micro controller further configured for i) selecting a first set of threshold voltages, ii) performing a first measurement using the first set of threshold voltages, iii) selecting a new set of threshold voltages different from the first set of threshold voltages, iv) performing a new measurement using the new set of threshold voltages, v) determining cell size distribution based on the first measurement and the new measurement.

    Abstract translation: 本发明涉及一种通过使用一种装置来确定脉冲高度分布的方法，该装置包括：模数 - 数字脉冲高度分类单元，用于使用微控制器对脉冲和模拟阈值电压进行比较并计数每个脉冲高度类别内的每个事件。 该方法可以包括以下步骤：i）选择第一组阈值电压，ii）使用第一组阈值电压执行第一测量，iii）选择不同于第一组阈值电压的新的阈值电压集合，iv ）使用新的一组阈值电压执行新的测量，v）基于第一测量和新测量来确定单元尺寸分布。 本发明还涉及一种包括比较脉冲与模拟阈值电压的模数 - 数字脉冲高度分类单元的装置，微控制器，被配置为对每个脉冲高度类别内的每个事件进行计数，微控制器进一步配置为：i）选择第一 一组阈值电压，ii）使用第一组阈值电压执行第一测量，iii）选择与第一组阈值电压不同的一组新的阈值电压，iv）使用新的阈值电压集执行新的测量 v）基于第一测量和新测量来确定单元尺寸分布。

    Dual Sample Cartridge and Method for Characterizing Particles in Liquid
    7.
    发明申请
    Dual Sample Cartridge and Method for Characterizing Particles in Liquid 有权
    双样品盒和液体中颗粒表征的方法

    公开(公告)号：US20080202217A1

    公开(公告)日：2008-08-28

    申请号：US11815884

    申请日：2006-02-10

    Applicant: Ulrik Darling Larsen

    Inventor： Ulrik Darling Larsen

    IPC: G01N33/00 ,  G01N1/00

    CPC classification number: G01N15/12 ,  G01N33/49

    Abstract: The present invention relates to an apparatus for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. Furthermore, the present invention relates to a method for characterizing particles in liquid and a device for sampling a small and accurate volume of liquid. The apparatus comprises a housing having a mixing chamber and a collection chamber separated by a wall containing an opening, a first bore in the outer surface of the housing for entrance of a liquid sample, a first cavity for receiving and holding a first liquid sample, and a second cavity for receiving and holding a second liquid sample.

    Abstract translation: 本发明涉及用于表征悬浮在液体中的颗粒的装置，特别是用于一次使用分析的独立一次性盒，例如用于少量全血的一次性分析。 此外，本发明涉及用于表征液体中的颗粒的方法以及用于对小量和精确体积的液体进行取样的装置。 该装置包括具有混合室和由包含开口的壁分离的收集室的壳体，用于引入液体样品的壳体外表面中的第一孔，用于接收和保持第一液体样品的第一腔， 以及用于接收和保持第二液体样品的第二腔。

    Detection and subsequent removal of an aperture blockage
    9.
    发明授权
    Detection and subsequent removal of an aperture blockage 有权
    检测并随后拆除孔堵塞

    公开(公告)号：US07968052B2

    公开(公告)日：2011-06-28

    申请号：US12067065

    申请日：2006-09-19

    Applicant: Rune Funder Mikkelsen ,  Ulrik Darling Larsen

    Inventor： Rune Funder Mikkelsen ,  Ulrik Darling Larsen

    IPC: G01N15/12

    CPC classification number: G01N15/1227 ,  G01N2015/1281

    Abstract: An apparatus which enables characterization of particles suspended in a liquid includes a housing with a mixing chamber and a collection chamber separated by a wall containing an aperture for passage of particles between, the mixing chamber and the collection chamber, the mixing chamber further containing a mixing member, a first electrode in the mixing chamber and a second electrode in the collection chamber for conduction of an electrical current through the aperture, a processor that is adapted for controlling the measurement sequence of the apparatus and detecting possible blockage of the aperture by detecting extended duration of the electrical pulse caused by the blocking particle, and upon detection of a blockage, reversing the liquid flow while mixing in the mixing chamber for removal of the blocking particle, and restarting particle counting.

    Abstract translation: 能够表征悬浮在液体中的颗粒的装置包括具有混合室的壳体和由包含用于在混合室和收集室之间通过颗粒的孔的壁隔开的收集室，混合室还包含混合 构件，混合室中的第一电极和用于传导电流通过孔的收集室中的第二电极，适于控制装置的测量顺序并通过检测延伸的孔来检测孔的可能阻塞的处理器 由阻塞颗粒引起的电脉冲的持续时间，并且在检测到阻塞时，在混合室中混合时反转液体流动以除去阻塞颗粒，并重新开始颗粒计数。

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