公开(公告)号：US20220174950A1

公开(公告)日：2022-06-09

申请号：US17600678

申请日：2020-03-18

Applicant: University of Exeter

Inventor： Gero Steinberg ,  Sarah Gurr ,  Mark Wood

IPC: A01N33/12 ,  A01N31/02 ,  A01N25/04 ,  A01P3/00

Abstract: The invention provides an antifungal composition comprising an antifungal compound of formula R—S+(R′)2 or R—N+(R′)3 wherein R is C17-C32 straight chain or branched alkyl; and each R′ is independently methyl, ethyl, propyl, isopropyl or butyl; and uses of said composition as antifungal agents.

公开(公告)号：US09346758B2

公开(公告)日：2016-05-24

申请号：US14425385

申请日：2013-09-02

Applicant: UNIVERSITY OF EXETER

Inventor： Alison Curnow ,  Mark Wood ,  Alexis Perry

IPC: C07D213/69 ,  A61K31/4412 ,  A61K41/00 ,  A61K49/00 ,  A61K8/49 ,  A61Q19/00

CPC classification number: C07D213/69 ,  A61K8/4926 ,  A61K41/0057 ,  A61K49/0021 ,  A61K2800/81 ,  A61Q19/00

Abstract: A compound which is a compound of formula (I) or any salt thereof: wherein R1 is a Ci-C6 alkyl group, R2 is H or a Ci-C6 alkyl group, R3 is H or a Ci-C6 alkyl group, and n is an integer from 0 to 5.

Abstract translation: 化合物，其为式（I）化合物或其盐：其中R 1为C 1 -C 6烷基，R 2为H或C 1 -C 6烷基，R 3为H或C 1 -C 6烷基，n为 是从0到5的整数。

公开(公告)号：US20150196034A1

公开(公告)日：2015-07-16

申请号：US14347782

申请日：2012-10-01

Applicant: THE UNIVERSITY OF EXETER

Inventor： Mark Wood ,  Matthew Whiteman ,  Alexis Perry

IPC: A01N57/24 ,  C07F9/54 ,  C07F9/6553

CPC classification number: A01N57/24 ,  A61K31/385 ,  A61K31/662 ,  A61K47/54 ,  C07F9/5442 ,  C07F9/655345

Abstract: The invention relates to a compound comprising a mitochondrial targeting group linked to group capable of releasing hydrogen sulfide, or a pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body by surgery or therapy. The invention also relates to the use of the compound in the treatment of a plant, and to certain forms of the compound.

Abstract translation: 本发明涉及包含与能够释放硫化氢的基团连接的线粒体靶向基团的化合物或其药学上可接受的盐，用于通过手术或治疗来治疗人或动物体。 本发明还涉及该化合物在处理植物和某些形式的化合物中的用途。

公开(公告)号：US10058100B2

公开(公告)日：2018-08-28

申请号：US14347782

申请日：2012-10-01

Applicant: THE UNIVERSITY OF EXETER

Inventor： Mark Wood ,  Matthew Whiteman ,  Alexis Perry

IPC: A01N57/24 ,  C07F9/54 ,  C07F9/6553 ,  A61K31/662 ,  A61K47/48 ,  A61K31/385

CPC classification number: A01N57/24 ,  A61K31/385 ,  A61K31/662 ,  A61K47/54 ,  C07F9/5442 ,  C07F9/655345

Abstract: The invention relates to a compound comprising a mitochondrial targeting group linked to group capable of releasing hydrogen sulfide, or a pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body by surgery or therapy. The invention also relates to the use of the compound in the treatment of a plant, and to certain forms of the compound.

公开(公告)号：US20150210642A1

公开(公告)日：2015-07-30

申请号：US14425385

申请日：2013-09-02

Applicant: UNIVERSITY OF EXETER

Inventor： Alison Curnow ,  Mark Wood ,  Alexis Perry

IPC: C07D213/69

CPC classification number: C07D213/69 ,  A61K8/4926 ,  A61K41/0057 ,  A61K49/0021 ,  A61K2800/81 ,  A61Q19/00

Abstract: A compound which is a compound of formula (I) or any salt thereof: wherein R1 is a Ci-C6 alkyl group, R2 is H or a Ci-C6 alkyl group, R3 is H or a Ci-C6 alkyl group, and n is an integer from 0 to 5.

Abstract translation: 化合物，其为式（I）化合物或其盐：其中R 1为C 1 -C 6烷基，R 2为H或C 1 -C 6烷基，R 3为H或C 1 -C 6烷基，n为 是从0到5的整数。