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    Low cost disposable medical sensor fabricated on glass, paper or plastics
    3.
    发明授权
    Low cost disposable medical sensor fabricated on glass, paper or plastics 有权

    公开(公告)号：US11531027B2

    公开(公告)日：2022-12-20

    申请号：US16206493

    申请日：2018-11-30

    Applicant: University of Florida Research Foundation, Inc.

    Inventor： Fan Ren ,  Stephen J. Pearton

    IPC: G01N33/543 ,  H01L29/778 ,  G01N33/68 ,  H01L29/20 ,  G01N27/414

    Abstract: Various examples are provided for low cost disposable medical sensors fabricated on glass, paper or plastics, and applications thereof. In one example, a medical sensor includes a base structure comprising a functionalized sensing area; and a transistor disposed on the base structure adjacent to the functionalized sensing area. In another example, a medical sensor includes a base structure comprising a functionalized sensing area disposed on a first electrode pad and a reference sensing area disposed on a second electrode pad separated from the first electrode pad; and a transistor having a gate electrically coupled to the second electrode pad of the base structure. A gate pulse applied to the functionalized sensing can produce a drain current corresponding to an amount of a target present in a sample disposed on the base structure.

    LOW COST DISPOSABLE MEDICAL SENSOR FABRICATED ON GLASS, PAPER OR PLASTICS
    4.
    发明申请
    LOW COST DISPOSABLE MEDICAL SENSOR FABRICATED ON GLASS, PAPER OR PLASTICS 审中-公开

    公开(公告)号：US20190170738A1

    公开(公告)日：2019-06-06

    申请号：US16206493

    申请日：2018-11-30

    Applicant: University of Florida Research Foundation, Inc.

    Inventor： Fan Ren ,  Stephen J. Pearton

    IPC: G01N33/543 ,  G01N33/68 ,  H01L29/20 ,  H01L29/778

    Abstract: Various examples are provided for low cost disposable medical sensors fabricated on glass, paper or plastics, and applications thereof. In one example, a medical sensor includes a base structure comprising a functionalized sensing area; and a transistor disposed on the base structure adjacent to the functionalized sensing area. In another example, a medical sensor includes a base structure comprising a functionalized sensing area disposed on a first electrode pad and a reference sensing area disposed on a second electrode pad separated from the first electrode pad; and a transistor having a gate electrically coupled to the second electrode pad of the base structure. A gate pulse applied to the functionalized sensing can produce a drain current corresponding to an amount of a target present in a sample disposed on the base structure.

    MODULARIZED INEXPENSIVE DETECTION OF CEREBRAL SPINAL FLUID FOR MEDICAL APPLICATIONS
    6.
    发明申请
    MODULARIZED INEXPENSIVE DETECTION OF CEREBRAL SPINAL FLUID FOR MEDICAL APPLICATIONS 审中-公开

    公开(公告)号：US20200333286A1

    公开(公告)日：2020-10-22

    申请号：US16851859

    申请日：2020-04-17

    Applicant: University of Florida Research Foundation, Inc.

    Inventor： Marino Leon ,  Brian C. Lobo ,  Stephen J. Pearton ,  Fan Ren ,  Yu-Te Liao

    IPC: G01N27/414 ,  H01L29/43 ,  H01L29/778 ,  H01L29/08 ,  C07K16/18 ,  G01N27/22 ,  G01N33/487

    Abstract: Various examples are provided for disposable medical sensors that can be used for the detection of cerebral spinal fluid. In one example, a medical sensing system includes a disposable sensing unit comprising a functionalized sensing area disposed between electrodes; and a portable sensing unit analyzer including pulse generation circuitry that can generate synchronized gate and drain pulses and a transistor with a gate electrically coupled to one electrode. A gate pulse output of the pulse generation circuitry is electrically coupled to a second electrode and a drain pulse output is electrically coupled to a drain of the transistor. In another example, a method includes providing a sample to a functionalized sensing area, generating synchronized gate and drain pulses for a transistor, the gate pulse provided via the electrodes and functionalized sensing area, and sensing an output of the transistor that is a function of a target concentration of the sample.

    Materials and methods for detecting toxins, pathogens and other biological materials
    7.
    发明授权
    Materials and methods for detecting toxins, pathogens and other biological materials 有权
    用于检测毒素，病原体和其他生物材料的材料和方法

    公开(公告)号：US09366645B2

    公开(公告)日：2016-06-14

    申请号：US14148945

    申请日：2014-01-07

    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

    Inventor： Fan Ren ,  Stephen John Pearton ,  Tanmay P. Lele

    IPC: G01N27/327 ,  G01N33/543 ,  G01N33/569 ,  G01N27/414

    CPC classification number: G01N27/3275 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/56911 ,  G01N33/56983 ,  G01N2333/33

    Abstract: Embodiments of the present invention provide binding molecule-functionalized high electron mobility transistors (HEMTs) that can be used to detect toxins, pathogens and other biological materials. In a specific embodiment, an antibody-functionalized HEMT can be used to detect botulinum toxin. The antibody can be anchored to a gold-layered gate area of the HEMT through immobilized thioglycolic acid. Embodiments of the subject detectors can be used in field-deployable electronic biological applications based on AlGaN/GaN HEMTs.

    Abstract translation: 本发明的实施方案提供可用于检测毒素，病原体和其他生物材料的结合分子官能化的高电子迁移率晶体管（HEMT）。 在具体实施方案中，抗体功能化的HEMT可用于检测肉毒杆菌毒素。 抗体可以通过固定化的巯基乙酸锚定在HEMT的金层门区。 本发明的检测器的实施例可以用于基于AlGaN / GaN HEMT的现场可部署电子生物学应用中。

    Dielectric coatings for fixed and removable oral prosthetic restorations
    10.
    发明授权
    Dielectric coatings for fixed and removable oral prosthetic restorations 有权

    公开(公告)号：US10813847B2

    公开(公告)日：2020-10-27

    申请号：US15772345

    申请日：2016-10-28

    Applicant: University of Florida Research Foundation, Inc.

    Inventor： Josephine F. Esquivel-Upshaw ,  Fan Ren ,  Arthur E. Clark

    IPC: B32B9/00 ,  A61K6/20 ,  A61K6/833 ,  A61K6/818 ,  C23C4/11 ,  A61C13/08

    Abstract: Dental prosthetic restoration coatings made of dielectric materials, methods of fabricating the same, as well as methods of testing dental prosthetic restorations are provided. A prosthetic restoration coating can include dielectric materials such as Al2O3, ZrO2, SiNx, SiC, and SiO2. Application can take place using plasma enhanced chemical vapor deposition (PECVD) methods, and alternating materials can be used to achieve desired anticorrosive, structural integrity, hardness, adhesion, and color characteristics. A testing method can include immersing a test device in solutions of differing pH, with or without abrasive steps. The cycling can include an acidic solution and a basic solution, with an optional neutral solution. As the abrasive step, a chewing simulator can be utilized.

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