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1.发明申请公开(公告)号：US20220105137A1
公开(公告)日：2022-04-07
申请号：US17323114
申请日：2021-05-18
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
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2.发明公开公开(公告)号：US20240197790A1
公开(公告)日：2024-06-20
申请号：US18349566
申请日：2023-07-10
CPC分类号： A61K35/34 , A61K9/0019 , C12N5/0658 , C12N5/0659 , A61K35/12 , C12N2500/84 , C12N2501/70 , C12N2510/00 , C12N2510/02 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction into a site of soft tissue. Also provided are methods of isolating MDCs. The invention further provides methods of using compositions comprising MDCs for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to uses of MDCs for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the novel use of MDCs for the increase of skeletal muscle.
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3.发明申请公开(公告)号：US20170209495A1
公开(公告)日：2017-07-27
申请号：US15347308
申请日：2016-11-09
CPC分类号： A61K35/34 , A61K9/0019 , A61K35/12 , C12N5/0658 , C12N5/0659 , C12N2500/84 , C12N2501/70 , C12N2510/00 , C12N2510/02 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction into a site of soft tissue. Also provided are methods of isolating MDCs. The invention further provides methods of using compositions comprising MDCs for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to uses of MDCs for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the novel use of MDCs for the increase of skeletal muscle.
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4.发明申请公开(公告)号：US20160213716A1
公开(公告)日：2016-07-28
申请号：US14978894
申请日：2015-12-22
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0654 , C12N5/0658 , C12N5/0659 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91 , C12N2506/13 , C12N2510/00
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
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5.发明申请公开(公告)号：US20180071341A1
公开(公告)日：2018-03-15
申请号：US15654046
申请日：2017-07-19
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0654 , C12N5/0658 , C12N5/0659 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91 , C12N2506/13 , C12N2510/00
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
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6.发明公开公开(公告)号：US20240181134A1
公开(公告)日：2024-06-06
申请号：US18345212
申请日：2023-06-30
发明人： Arvydas Usas , Karin Payne , Thomas Payne , Ronald Jankowski , Johnny Huard
IPC分类号： A61L27/38 , A61K35/12 , A61K35/38 , A61L27/36 , A61L27/54 , A61L27/58 , C12N5/077 , C12N11/02
CPC分类号： A61L27/3895 , A61K35/38 , A61L27/3629 , A61L27/365 , A61L27/3826 , A61L27/3847 , A61L27/54 , A61L27/58 , C12N5/0652 , C12N5/0658 , C12N5/0659 , C12N11/02 , A61K35/12 , A61L2300/64 , A61L2430/02 , A61L2430/40 , C12N2533/92
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
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公开(公告)号：US20220096714A1
公开(公告)日：2022-03-31
申请号：US17316854
申请日：2021-05-11
发明人： Arvydas Usas , Karin Payne , Thomas Payne , Ronald Jankowski , Johnny Huard
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
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8.发明申请Bone Augmentation Utilizing Muscle-Derived Progenitor Compositions in Biocompatible Matrix, and Treatments Thereof 审中-公开骨骼增生利用生物相容性基质中肌肉衍生的祖细胞组成及其治疗公开(公告)号：US20150044185A1
公开(公告)日：2015-02-12
申请号：US14499853
申请日：2014-09-29
发明人： Arvydas Usas , Karin Payne , Thomas Payne , Ronald Jankowski , Johnny Huard
CPC分类号： A61L27/3895 , A61K35/12 , A61K35/38 , A61L27/3629 , A61L27/365 , A61L27/3826 , A61L27/3847 , A61L27/54 , A61L27/58 , A61L2300/64 , A61L2430/02 , A61L2430/40 , C12N5/0659 , C12N11/02 , C12N2533/92
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译： 本发明提供肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如经由注射，移植或植入）之后增加非软组织到非软组织部位（例如， 骨）与生物相容性基质（优选SIS）组合时。 本发明还提供了使用包含肌源性祖细胞的组合物与生物相容性基质的方法，用于在治疗各种功能状况（包括骨质疏松症，佩吉特氏病，成骨不全，骨折）中增加和膨胀哺乳动物，包括人类骨组织 ，骨软化，骨小梁强度降低，骨皮质强度下降，老年骨密度降低。
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9.发明申请Bone Augmentation Utilizing Muscle-Derived Progenitor Compositions, And Treatments Thereof 审中-公开骨骼增生利用肌肉衍生的祖先组合物及其治疗方法公开(公告)号：US20130156741A1
公开(公告)日：2013-06-20
申请号：US13766901
申请日：2013-02-14
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0654 , C12N5/0658 , C12N5/0659 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91 , C12N2506/13 , C12N2510/00
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译： 本发明提供肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如经由注射，移植或植入）之后增加非软组织到非软组织部位（例如， 骨）。 还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。 本发明还提供了使用包含肌肉来源的祖细胞的组合物用于增加和膨胀哺乳动物（包括人类）骨组织以治疗各种功能状况的方法，包括骨质疏松症，佩吉特氏病，成骨不全，骨折，骨软化，减少 在骨小梁强度，骨皮质强度下降和老年骨密度降低。
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10.发明申请公开(公告)号：US20210145892A1
公开(公告)日：2021-05-20
申请号：US16908037
申请日：2020-06-22
摘要： The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction into a site of soft tissue. Also provided are methods of isolating MDCs. The invention further provides methods of using compositions comprising MDCs for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to uses of MDCs for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the novel use of MDCs for the increase of skeletal muscle.
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