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公开(公告)号：US20190151499A1
公开(公告)日：2019-05-23
申请号：US16222918
申请日：2018-12-17
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US11154639B2
公开(公告)日：2021-10-26
申请号：US16222918
申请日：2018-12-17
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
IPC分类号： A61K47/34 , A61L27/18 , A61K35/30 , A61L27/38 , A61K35/545 , A61P27/00 , C12N5/079 , A61L27/34 , A61K9/00 , A61L27/56
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US10188769B2
公开(公告)日：2019-01-29
申请号：US14314994
申请日：2014-06-25
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US20240049701A1
公开(公告)日：2024-02-15
申请号：US18483917
申请日：2023-10-10
发明人： Britney O. Pennington , Jeffrey K. Bailey , Mohamed A. Faynus , Cassidy Arnold , Lincoln V. Johnson , Dennis O. Clegg , Mark S. Humayun , David R. Hinton , Danhong Zhu , Debbie Mitra
CPC分类号： A01N1/021 , C12N5/0621 , C08G61/025
摘要： Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
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公开(公告)号：US11825839B2
公开(公告)日：2023-11-28
申请号：US16557897
申请日：2019-08-30
发明人： Britney O. Pennington , Jeffrey K. Bailey , Mohamed A. Faynus , Cassidy Arnold , Lincoln V. Johnson , Dennis O. Clegg , Mark S. Humayun , David R. Hinton , Danhong Zhu , Debbie Mitra
CPC分类号： A01N1/021 , C12N5/0621 , C08G61/025
摘要： Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
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公开(公告)号：US20200077641A1
公开(公告)日：2020-03-12
申请号：US16557897
申请日：2019-08-30
发明人： Britney O. Pennington , Jeffrey K. Bailey , Mohamed A. Faynus , Cassidy Arnold , Lincoln V. Johnson , Dennis O. Clegg , Mark S. Humayun , David R. Hinton , Danhong Zhu , Debbie Mitra
摘要： Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
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公开(公告)号：US10246682B2
公开(公告)日：2019-04-02
申请号：US15816912
申请日：2017-11-17
发明人： Dennis Clegg , Sherry T. Hikita , Lincoln V. Johnson , Liane Miller , Marlene Tsie , Chelsea D. Presbrey , Lisa R. Conti , Michelle A. Maloney , David R. Hinton , Qirui Hu
摘要： The production of high quality retinal pigmented epithelium (RPE) cells is necessary for research and potential therapeutic uses. Especially desirable are methods for the production of RPE cells using xeno-free culture conditions. Disclosed herein are novel methods for the production of RPE cells from pluripotent cells with high yields, including xeno-free production methods. Also provided are methods of efficiently isolating RPE cells from cultures containing heterogeneous cell types, allowing for substantially pure RPE cell cultures to be established. Additionally, novel methods for the cryopreservation of RPE cells are provided.
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公开(公告)号：US11533908B2
公开(公告)日：2022-12-27
申请号：US16658457
申请日：2019-10-21
发明人： Danhong Zhu , David R. Hinton , Ashish Ahuja , Mark S. Humayun
摘要： Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
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9.发明申请公开(公告)号：US20200045957A1
公开(公告)日：2020-02-13
申请号：US16658457
申请日：2019-10-21
发明人： Danhong Zhu , David R. Hinton , Ashish Ahuja , Mark S. Humayun
摘要： Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
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