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公开(公告)号：US20190151499A1
公开(公告)日：2019-05-23
申请号：US16222918
申请日：2018-12-17
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US11154639B2
公开(公告)日：2021-10-26
申请号：US16222918
申请日：2018-12-17
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
IPC分类号： A61K47/34 , A61L27/18 , A61K35/30 , A61L27/38 , A61K35/545 , A61P27/00 , C12N5/079 , A61L27/34 , A61K9/00 , A61L27/56
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US10188769B2
公开(公告)日：2019-01-29
申请号：US14314994
申请日：2014-06-25
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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4.发明申请公开(公告)号：US20170196221A1
公开(公告)日：2017-07-13
申请号：US15418099
申请日：2017-01-27
发明人： Danhong Zhu , David Hinton , Ashish Ahuja , Mark Humayun
CPC分类号： A01N1/0252 , A01N1/0268 , A01N1/0284 , A61L27/16 , A61L27/34 , A61L27/3813 , A61L27/3834 , A61L27/58 , C12N5/0621
摘要： Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
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公开(公告)号：US09274095B2
公开(公告)日：2016-03-01
申请号：US14791007
申请日：2015-07-02
发明人： Mark Humayun , Ashish Ahuja , Charles Le Pere
IPC分类号： G06K9/00 , G01N33/483 , G01N21/59
CPC分类号： G01N33/4833 , A61B3/12 , A61F9/00 , A61F9/0017 , A61K49/0017 , A61L27/38 , A61L27/3834 , G01N21/59 , G01N21/6486 , G01N2201/12 , G06T7/0012 , G06T2207/10004 , G06T2207/30024
摘要： Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging of cell-seeded substrates implanted in target tissues in the context of stem cell therapy.
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6.发明申请SYSTEMS AND METHODS FOR IN VITRO AND IN VIVO IMAGING OF CELLS ON A SUBSTRATE 有权用于体外和体细胞在基底上成像的系统和方法公开(公告)号：US20150309009A1
公开(公告)日：2015-10-29
申请号：US14791007
申请日：2015-07-02
发明人： Mark Humayun , Ashish Ahuja , Charles Le Pere
IPC分类号： G01N33/483 , G01N21/59
CPC分类号： G01N33/4833 , A61B3/12 , A61F9/00 , A61F9/0017 , A61K49/0017 , A61L27/38 , A61L27/3834 , G01N21/59 , G01N21/6486 , G01N2201/12 , G06T7/0012 , G06T2207/10004 , G06T2207/30024
摘要： Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging of cell-seeded substrates implanted in target tissues in the context of stem cell therapy.
摘要翻译： 本文公开的方法和系统通常是促进基底上的细胞成像的方法和系统，更具体地涉及植入到目标组织中的细胞种植基质（茎）的植入前（体外）和植入后（体内）成像 细胞治疗。
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公开(公告)号：US11533908B2
公开(公告)日：2022-12-27
申请号：US16658457
申请日：2019-10-21
发明人： Danhong Zhu , David R. Hinton , Ashish Ahuja , Mark S. Humayun
摘要： Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
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8.发明申请公开(公告)号：US20200045957A1
公开(公告)日：2020-02-13
申请号：US16658457
申请日：2019-10-21
发明人： Danhong Zhu , David R. Hinton , Ashish Ahuja , Mark S. Humayun
摘要： Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
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公开(公告)号：US10247719B2
公开(公告)日：2019-04-02
申请号：US15004712
申请日：2016-01-22
发明人： Mark Humayun , Ashish Ahuja , Charles Le Pere
摘要： Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging of cell-seeded substrates implanted in target tissues in the context of stem cell therapy.
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10.发明授权公开(公告)号：US10470457B2
公开(公告)日：2019-11-12
申请号：US15418099
申请日：2017-01-27
发明人： Danhong Zhu , David Hinton , Ashish Ahuja , Mark Humayun
摘要： Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
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