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公开(公告)号：US20190151499A1
公开(公告)日：2019-05-23
申请号：US16222918
申请日：2018-12-17
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US11154639B2
公开(公告)日：2021-10-26
申请号：US16222918
申请日：2018-12-17
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
IPC分类号： A61K47/34 , A61L27/18 , A61K35/30 , A61L27/38 , A61K35/545 , A61P27/00 , C12N5/079 , A61L27/34 , A61K9/00 , A61L27/56
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US10188769B2
公开(公告)日：2019-01-29
申请号：US14314994
申请日：2014-06-25
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US20230346886A1
公开(公告)日：2023-11-02
申请号：US18076786
申请日：2022-12-07
申请人： California Institute of Technology , The Regents of the University of California , U.S. Government represented by the Department of Veterans Affairs
CPC分类号： A61K38/1891 , A61B3/102 , A61B3/1241 , A61K9/0048 , A61K38/1866 , A61P27/02
摘要： Disclosed herein include methods, kits, formulations, and compositions for increasing choroidal or retinal perfusion or promoting non-leaking or minimally-leaking choroidal or retinal revascularization in a subject in need thereof. An effective amount of an angiogenesis factor (e.g., a pro-angiogenic factor and/or a vascular maturation factor) can be administered to the subject.
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公开(公告)号：US20220088198A1
公开(公告)日：2022-03-24
申请号：US17544630
申请日：2021-12-07
发明人： Robert H. Grubbs , Marshall L. Stoller , Hoyong Chung , Alissa M. Fitzgerald , Thomas W. Kenny , Renee M. Thomas
IPC分类号： A61K41/00 , A61K9/00 , A61K9/107 , A61K47/69 , A61B17/22 , A61K31/663 , A61K47/24 , A61N7/00
摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
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公开(公告)号：US10357565B2
公开(公告)日：2019-07-23
申请号：US16154677
申请日：2018-10-08
发明人： Robert H. Grubbs , Marshall L. Stoller , Hoyong Chung , Alissa M. Fitzgerald , Thomas W. Kenny , Renee M. Thomas
IPC分类号： A61K41/00 , A61B17/22 , A61K47/24 , A61K31/663 , A61K9/00 , A61K9/107 , A61N7/00 , A61K47/69
摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
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公开(公告)号：US10149906B2
公开(公告)日：2018-12-11
申请号：US15199710
申请日：2016-06-30
发明人： Robert H. Grubbs , Marshall L. Stoller , Hoyong Chung , Alissa M. Fitzgerald , Thomas W. Kenny , Renee M. Thomas
IPC分类号： A61K41/00 , A61K9/00 , A61B17/22 , A61K47/24 , A61N7/00 , A61K9/107 , A61K31/663 , A61K47/69
摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
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公开(公告)号：US11642410B2
公开(公告)日：2023-05-09
申请号：US17544630
申请日：2021-12-07
发明人： Robert H. Grubbs , Marshall L. Stoller , Hoyong Chung , Alissa M. Fitzgerald , Thomas W. Kenny , Renee M. Thomas
IPC分类号： A61K41/00 , A61K9/00 , A61K9/107 , A61K47/69 , A61B17/22 , A61K31/663 , A61K47/24 , A61N7/00
CPC分类号： A61K41/0028 , A61B17/2202 , A61B17/22004 , A61B17/22022 , A61K9/0009 , A61K9/0019 , A61K9/1075 , A61K31/663 , A61K41/0033 , A61K47/24 , A61K47/6911 , A61N7/00 , A61B2017/22007 , A61B2017/22008 , A61N2007/0039
摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
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公开(公告)号：US20190282695A1
公开(公告)日：2019-09-19
申请号：US16431605
申请日：2019-06-04
发明人： Robert H. Grubbs , Marshall Leedy Stoller , Hoyong Chung , Alissa M. Fitzgerald , Thomas W. Kenny , Renee M. Thomas
IPC分类号： A61K41/00 , A61B17/22 , A61K47/69 , A61N7/00 , A61K9/00 , A61K9/107 , A61K31/663 , A61K47/24
摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
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公开(公告)号：US11170625B2
公开(公告)日：2021-11-09
申请号：US16417525
申请日：2019-05-20
发明人： Robert H. Grubbs , Hyuck Choo , Frank L. Brodie
摘要： A position sensing system comprises a position sensor having an accelerometer and a gyroscope, an alarm, and a controller configured to receive data from the position sensor and activate the alarm according to alarm management instructions stored in a memory. In some embodiments, the alarm instructions include a snooze option to allow the user/patient to temporarily deactivate the alarm. The controller is communicably linked to a remote display device configured to display the orientation of the user's body part.
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