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    Use of protein biomolecular targets in the treatment and visualization of brain tumors
    2.
    发明授权
    Use of protein biomolecular targets in the treatment and visualization of brain tumors 失效

    公开(公告)号：US07060275B2

    公开(公告)日：2006-06-13

    申请号：US10652981

    申请日：2003-08-28

    申请人： Sabine Mueller ,  Thorsten Melcher ,  Daniel Chin

    发明人： Sabine Mueller ,  Thorsten Melcher ,  Daniel Chin

    IPC分类号： A61K39/395 ,  A61K39/40 ,  C07H21/02

    CPC分类号： A61K49/0002

    摘要： The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents which specifically bind to one or more of human proteins angiopoietin related protein 2 (ARP-2,) secreted protein acidic, rich in cysteine (SPARC,) c-met proto-oncogene (C-MET,) brevican (BEHAB,) CD-44 antigen (CD-44,) tetraspanin 3 (TSPN3,) pleiotrophin (PTN,) osteopontin (OPN,) vasoactive intestinal peptide receptor-2 (VIPR-2,) and receptor protein tyrosine phosphatase zeta (PTPζ) for the treatment and visualization of brain tumors in patients. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. The present invention also provides novel splice variants of protein PTPζ, PTPζ SM1 and PTPζ SM2. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.

    Use of protein biomolecular targets in the treatment and visualization of brain tumors
    3.
    发明申请
    Use of protein biomolecular targets in the treatment and visualization of brain tumors 失效
    蛋白质生物分子靶标在脑肿瘤的治疗和可视化中的应用

    公开(公告)号：US20050074400A1

    公开(公告)日：2005-04-07

    申请号：US10652981

    申请日：2003-08-28

    申请人： Sabine Mueller ,  Thorsten Melcher ,  Daniel Chin

    发明人： Sabine Mueller ,  Thorsten Melcher ,  Daniel Chin

    IPC分类号： A61K49/00 ,  A61K51/00 ,  A61K39/395

    CPC分类号： A61K49/0002

    摘要： The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents which specifically bind to one or more of human proteins angiopoietin related protein 2 (ARP-2,) secreted protein acidic, rich in cysteine (SPARC,) c-met proto-oncogene (C-MET,) brevican (BEHAB,) CD-44 antigen (CD-44,) tetraspanin 3 (TSPN3,) pleiotrophin (PTN,) osteopontin (OPN,) vasoactive intestinal peptide receptor-2 (VIPR-2,) and receptor protein tyrosine phosphatase zeta (PTPζ) for the treatment and visualization of brain tumors in patients. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. The present invention also provides novel splice variants of protein PTPζ, PTPζ SM1 and PTPζ SM2. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.

    摘要翻译： 本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为脑肿瘤治疗疗法的生物分子靶标的用途。 具体地，本发明涉及特异性结合一种或多种人蛋白质的血管生成素相关蛋白2（ARP-2）分泌的蛋白质，富含半胱氨酸（SPARC）c-met原核蛋白的免疫治疗和免疫成像剂的用途。 癌基因（C-MET，）brevican（BEHAB）CD-44抗原（CD-44）四质蛋白3（TSPN3）多效素（PTN）骨桥蛋白（OPN）血管活性肠肽受体-2（VIPR-2） 和受体蛋白酪氨酸磷酸酶ζ（PTPzeta），用于治疗和观察患者脑肿瘤。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。 本发明还提供蛋白质PTPzeta，PTPzeta SM1和PTPzeta SM2的新型剪接变体。 还提供了针对编码这些变体的剪接mRNA特异性的核酸探针和对新蛋白特异的亲和试剂。

    Use of protein tyrosine phosphatase zeta as a biomolecular target in the treatment and visualization of brain tumors
    4.
    发明授权
    Use of protein tyrosine phosphatase zeta as a biomolecular target in the treatment and visualization of brain tumors 失效
    使用蛋白酪氨酸磷酸酶ζ作为生物分子靶向治疗和可视化脑肿瘤

    公开(公告)号：US06455026B1

    公开(公告)日：2002-09-24

    申请号：US09816703

    申请日：2001-03-23

    申请人： Sabine Mueller ,  Thorsten Melcher ,  Daniel J. Chin

    发明人： Sabine Mueller ,  Thorsten Melcher ,  Daniel J. Chin

    IPC分类号： A61K5100

    CPC分类号： A61K51/1093 ,  A61K47/6871 ,  A61K51/1075

    摘要： The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents that specifically bind to human protein tyrosine phosphatase-zeta (PTP&zgr;) for the treatment and visualization of brain tumors in patients. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.

    摘要翻译： 本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为脑肿瘤治疗疗法的生物分子靶标的用途。 具体地，本发明涉及特异性结合人蛋白质酪氨酸磷酸酶ζ（PTP＆zgr）用于治疗和观察患者脑肿瘤的免疫治疗和免疫成像剂的用途。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。

    Method of diagnosing ischemic stroke via UCP-2 detection
    6.
    发明授权
    Method of diagnosing ischemic stroke via UCP-2 detection 失效
    通过UCP-2检测诊断缺血性卒中的方法

    公开(公告)号：US06670138B2

    公开(公告)日：2003-12-30

    申请号：US10001051

    申请日：2001-10-31

    申请人： Mirella Gonzalez-Zulueta ,  Mehrdad Shamloo ,  K.C. McFarland ,  Daniel Chin ,  Tadeusz Wieloch ,  Thorsten Melcher

    发明人： Mirella Gonzalez-Zulueta ,  Mehrdad Shamloo ,  K.C. McFarland ,  Daniel Chin ,  Tadeusz Wieloch ,  Thorsten Melcher

    IPC分类号： C12Q170

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention identifies a gene whose gene product provides a protective effect against neurological disorders or neuronal injuries. Further, the invention provides methods for diagnosing or assessing an individual's susceptibility to a neuronal injury such as stroke. Also provided are therapeutic methods for treating patients, and methods for prophylactically treating individuals susceptible to various neurological disorders or neuronal injuries. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered or are at risk to suffer such disorders or injuries.

    摘要翻译： 本发明鉴定其基因产物对神经系统疾病或神经元损伤具有保护作用的基因。 此外，本发明提供了用于诊断或评估个体对诸如中风的神经元损伤的易感性的方法。 还提供了用于治疗患者的治疗方法，以及用于预防性治疗对各种神经障碍或神经元损伤敏感的个体的方法。 另外，本发明描述了用于鉴定可以被施用以治疗遭受或有遭受这种障碍或损伤风险的个体的药剂的筛选方法。

    Interaction of NMDA receptor with protein serine threonine phosphatases
    10.
    发明申请
    Interaction of NMDA receptor with protein serine threonine phosphatases 审中-公开
    NMDA受体与蛋白丝氨酸苏氨酸磷酸酶的相互作用

    公开(公告)号：US20050074831A1

    公开(公告)日：2005-04-07

    申请号：US10386971

    申请日：2003-03-11

    申请人： Jasna Jerecic ,  Janice Williams ,  Jean Bucaria ,  Thorsten Melcher

    发明人： Jasna Jerecic ,  Janice Williams ,  Jean Bucaria ,  Thorsten Melcher

    IPC分类号： G01N33/94 ,  C12Q1/44

    CPC分类号： G01N33/9406 ,  G01N2500/00

    摘要： The present invention relates to the identification of a binding between NMDA receptor (NMDA-R) subunits and a serine/threonine protein phosphatase (PSTP), e.g., PP2A. The present invention provides methods for screening a PSTP agonist or antagonist that modulates NMDA-R signaling. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal NMDA-R signaling.

    摘要翻译： 本发明涉及鉴定NMDA受体（NMDA-R）亚基与丝氨酸/苏氨酸蛋白磷酸酶（PSTP）如PP2A之间的结合。 本发明提供了筛选调节NMDA-R信号传导的PSTP激动剂或拮抗剂的方法。 本发明还提供了用于治疗由NMDA-R异常信号传导介导的病症的方法和组合物。