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公开(公告)号：US20160228414A1
公开(公告)日：2016-08-11
申请号：US15010542
申请日：2016-01-29
发明人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D.J. Grootenhuis
IPC分类号： A61K31/426 , A61K31/5377 , A61K31/454 , A61K31/4439
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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2.发明申请MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 有权CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR的调节剂公开(公告)号：US20140235625A1
公开(公告)日：2014-08-21
申请号：US14100748
申请日：2013-12-09
发明人： Hayley Binch , Dennis Hurley , Lev T.D. Fanning , Peter D.J. Grootenhuis , Martyn Botfield , Fredrick Van Goor
IPC分类号： C07D279/16 , A61K45/06 , A61K31/5415
CPC分类号： A61K31/5415 , A61K31/538 , A61K45/06 , C07D265/36 , C07D279/16 , C07D413/12
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using such CFTR modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种CFTR调节剂治疗疾病的方法。
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公开(公告)号：US20140228399A2
公开(公告)日：2014-08-14
申请号：US14074158
申请日：2013-11-07
发明人： Hayley Binch , Lev T.D. Fanning , Martyn Botfield , Peter D.J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , C07D487/08 , Y02P20/55
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
摘要翻译： 本发明涉及囊性纤维化跨膜传导调节剂（“CFTR”）的调节剂，其组合物及其方法。 本发明还涉及使用CFTR的调节剂治疗疾病的方法。
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公开(公告)号：US20210023070A1
公开(公告)日：2021-01-28
申请号：US16842480
申请日：2020-04-07
发明人： William Rowe , Patricia Hurter , Christopher Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi
摘要： The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
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公开(公告)号：US20150025076A1
公开(公告)日：2015-01-22
申请号：US14506856
申请日：2014-10-06
发明人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D.J. Grootenhuis
IPC分类号： C07D417/06 , C07D277/46 , C07D277/82
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
摘要： The present invention relates to modulator of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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6.发明申请MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VPI 审中-公开CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VPI的调节剂公开(公告)号：US20140235668A1
公开(公告)日：2014-08-21
申请号：US14208319
申请日：2014-03-13
IPC分类号： C07D495/04
CPC分类号： C07D495/04 , A61K31/4365
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20130303570A1
公开(公告)日：2013-11-14
申请号：US13944171
申请日：2013-07-17
发明人： Hayley Binch , Lev T.D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D.J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号： C07D487/08 , G01N33/68 , C07F7/18 , A61K45/06 , A61K31/4709 , C07D451/02
CPC分类号： A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
摘要翻译： 本发明涉及囊性纤维化跨膜传导调节剂（“CFTR”）的调节剂，其组合物及其方法。 本发明还涉及使用CFTR的调节剂治疗疾病的方法。
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公开(公告)号：US20130165442A1
公开(公告)日：2013-06-27
申请号：US13690924
申请日：2012-11-30
发明人： Urvi Sheth , Lev T.D. Fanning , Mehdi Michael Djamel Numa , Hayley Binch , Dennis Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick Van Goor , Peter D.J. Grootenhuis , Martyn Botfield
IPC分类号： C07D215/56 , C07D401/12 , A61K31/4709 , C07D405/12 , G01N33/68 , A61K31/5377 , A61K31/496 , C07D417/12 , A61K45/06 , A61K31/47 , C07D407/12
CPC分类号： C07C215/76 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/42 , C07D209/94 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/38 , C07D215/56 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/10
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20170107206A1
公开(公告)日：2017-04-20
申请号：US15173325
申请日：2016-06-03
发明人： Sara S. HADIDA RUAH , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US20150336898A1
公开(公告)日：2015-11-26
申请号：US14817633
申请日：2015-08-04
IPC分类号： C07D215/56 , C12Q1/34 , C07F9/60 , A61K31/675 , A61K31/47 , A61K45/06
CPC分类号： G01N33/502 , A61K31/47 , A61K31/675 , A61K45/06 , C07D215/56 , C07F9/60 , C12Q1/34 , G01N33/6872 , G01N2333/914 , G01N2500/10 , G01N2500/20
摘要： The present invention relates to prodrugs of modulators of ABC transporters, particularly, CFTR modulators, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ABC转运蛋白调节剂的前体药物，特别是CFTR调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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