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公开(公告)号：US10543348B2
公开(公告)日：2020-01-28
申请号：US16185044
申请日：2018-11-09
申请人： VIBRANT LTD.
发明人： Lior Ben-Tsur
摘要： A method of using a vibrating gastrointestinal capsule in coordination with an ingestible medicament for treatment of an ailment of the GI tract. The vibrating gastrointestinal capsule, is provided to the subject, and includes: a housing; a vibrating agitation mechanism causing the housing to exert vibrations on an environment thereof; a power supply for powering said vibrating agitation mechanism; and a control mechanism for activating said vibrating agitation mechanism to operate in said vibration mode of operation. The subject ingests the ingestible medicament and the vibrating gastrointestinal capsule. At least one of a time of ingesting of the vibrating gastrointestinal capsule and a timing or activation delay of the vibration mode of operation is controlled, such that the vibration mode of operation at least partially transpires or completely transpires within an actual or estimated absorption time period of the ingestible medicament within the gastrointestinal tract of the subject.
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2.发明授权公开(公告)号：US12115330B2
公开(公告)日：2024-10-15
申请号：US17419187
申请日：2020-01-02
申请人： VIBRANT LTD.
发明人： Lior Ben-Tsur , Shai Molnar , Ronny Shabbat
CPC分类号： A61M31/002 , A61B5/0051 , A61B5/073 , A61B5/42 , A61B5/4839 , A61B5/6861 , A61K9/0053 , A61M31/00 , A61M37/00 , A61B2562/162 , A61M2205/3306 , A61M2205/3327 , A61M2205/3341 , A61M2205/3344 , A61M2205/3368 , A61M2205/8206 , A61M2210/1053 , A61M2210/106 , A61M2210/1064
摘要： Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitation mechanism disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.
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3.发明授权公开(公告)号：US10888277B1
公开(公告)日：2021-01-12
申请号：US15882289
申请日：2018-01-29
申请人： VIBRANT LTD.
发明人： Lior Ben-Tsur , Camille Morliere
摘要： A method for treating diarrhea in a subject and/or for reducing Bristol stool scores of fecal matter of a subject using a vibrating ingestible capsule ingested by the subject and activated in a targeted zone of the gastrointestinal tract of the subject.
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公开(公告)号：US12090112B2
公开(公告)日：2024-09-17
申请号：US17233587
申请日：2021-04-19
申请人： VIBRANT LTD.
发明人： Lior Ben-Tsur , Shai Molnar , Roni Shabat , Shalom Lampert
CPC分类号： A61H23/02 , A47L17/00 , A61B5/073 , A61B5/6861 , A61B10/0038 , E03D9/00 , A61H2201/1207 , A61H2201/5005 , A61H2205/083
摘要： A system and a method for treatment of a disorder in a gastrointestinal tract of a subject, using a treatment protocol, the treatment protocol being based at least in part on data relating to other subjects and their responses to treatment with various treatment protocols.
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公开(公告)号：US12083303B2
公开(公告)日：2024-09-10
申请号：US17246643
申请日：2021-05-02
申请人： VIBRANT LTD.
发明人： Lior Ben-Tsur , Ronny Shabat , Shai Molnar
CPC分类号： A61M31/002 , A61M39/22 , A61M2039/226 , A61M2202/0468 , A61M2205/106 , A61M2205/3523 , A61M2205/502 , A61M2205/8212 , A61M2210/1053
摘要： A device and a method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user. The device includes a vibrating ingestible capsule attached to a medicament delivery compartment. The medicament delivery compartment includes a housing including a portal, a medicament reservoir, a reservoir biasing mechanism applying pressure to the reservoir, a resilient conduit extending from the reservoir to the portal, and a valve including a weight and a spring adapted, when closed, to bias the weight against the conduit so as to block flow therethrough, and, when open, to remove the weight from the conduit to allow fluid to flow through the conduit. When the vibrating agitator is in the vibration mode of operation, vibrations exerted thereby are applied to the valve biasing mechanism and periodically transition the valve between the closed operative orientation and the open operative orientation.
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公开(公告)号：US11510590B1
公开(公告)日：2022-11-29
申请号：US16403553
申请日：2019-05-05
申请人： VIBRANT LTD.
发明人： Lior Ben-Tsur , Shalom Lampert
摘要： A method for treating a human subject suffering from a gastrointestinal disorder using a non-dissolvable ingestible capsule, the method including providing the non-dissolvable ingestible capsule to the subject, and subsequently, ingesting the non-dissolvable ingestible capsule by the subject, wherein passage of the non-dissolvable ingestible capsule through the gastrointestinal tract of the subject treats the gastrointestinal disorder, and wherein the non-dissolvable ingestible capsule may be at least one of: a non-vibrating capsule, a capsule that is devoid of any electronic components, and a capsule that is devoid of any mechanical moving components.
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7.发明授权公开(公告)号：US11504024B2
公开(公告)日：2022-11-22
申请号：US17461053
申请日：2021-08-30
申请人： Vibrant Ltd.
发明人： Lior Ben-Tsur , Shai Molnar , Roni Shabat
摘要： A gastrointestinal treatment system including a gastrointestinal capsule adapted to treat a subject following ingestion of the gastrointestinal capsule. The gastrointestinal capsule includes: (a) a housing; (b) a vibrating agitator, powered by the battery, the vibrating agitator adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; (c) a power supply disposed within the housing and adapted to power the vibrating agitator; and (d) a controller adapted, in response to receipt of an activation input, to activate the vibrating agitator to operate in the first vibrating mode of operation at at least one predetermined time of day. The system and method may be used to treat an ailment of the gastrointestinal tract and/or to mitigate at least one symptom of jetlag in a subject travelling from an origin location to a destination location.
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公开(公告)号：US10905378B1
公开(公告)日：2021-02-02
申请号：US15882329
申请日：2018-01-29
申请人： VIBRANT LTD.
发明人： Lior Ben-Tsur , Camille Morliere
摘要： A method for treating gastroparesis in a subject using a vibrating ingestible capsule ingested by the subject and activated in a targeted zone of the gastrointestinal tract of the subject.
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公开(公告)号：US10537720B2
公开(公告)日：2020-01-21
申请号：US16178425
申请日：2018-11-01
申请人： VIBRANT LTD.
发明人： Lior Ben-Tsur
摘要： A method of using a vibrating gastrointestinal capsule in coordination with an ingestible medicament for treatment of Parkinsonism. The vibrating gastrointestinal capsule, is provided to the subject, and includes: a housing; a vibrating agitation mechanism causing said housing to exert vibrations on an environment surrounding the vibrating gastrointestinal capsule; a power supply for powering said vibrating agitation mechanism; and a control mechanism for activating said vibrating agitation mechanism to operate in said vibration mode of operation. The subject ingests the ingestible medicament and the vibrating gastrointestinal capsule. At least one of a time of ingesting of the vibrating gastrointestinal capsule and a timing or activation delay of the vibration mode of operation is controlled, such that the vibration mode of operation at least partially transpires or completely transpires within an actual or estimated absorption time period of the ingestible medicament within the gastrointestinal tract of the subject.
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公开(公告)号：US11638678B1
公开(公告)日：2023-05-02
申请号：US16377213
申请日：2019-04-07
申请人： VIBRANT LTD.
发明人： Lior Ben-Tsur
摘要： A vibrating gastrointestinal capsule and method of use thereof for treating Parkinsonism in a subject, the method including: (a) providing a vibrating gastrointestinal capsule having a housing; a vibrating agitation mechanism adapted such that, in a vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; and a power supply disposed within the housing and adapted to power the vibrating agitation mechanism; (b) ingesting the capsule, by the subject; and (c) controlling the vibrating agitation mechanism such that at least a portion of the vibrating mode of operation occurs within the stomach and/or the small intestine of the subject.
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