公开(公告)号：US20160228380A1

公开(公告)日：2016-08-11

申请号：US15023619

申请日：2014-09-23

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Mark A. McHugh ,  Rajendar Reddy Mallepally ,  Kevin R. Ward ,  Gary S. Huvard

IPC: A61K9/70 ,  A61K47/38 ,  A61L15/28 ,  A61L15/18 ,  A61K9/06 ,  A61L15/44 ,  A61K31/025 ,  A61K47/02 ,  A61K45/06 ,  A61K33/40 ,  A61L15/42

CPC classification number: A61K9/7007 ,  A61K9/06 ,  A61K9/5026 ,  A61K31/025 ,  A61K31/327 ,  A61K33/40 ,  A61K45/06 ,  A61K47/02 ,  A61K47/38 ,  A61L15/18 ,  A61L15/26 ,  A61L15/28 ,  A61L15/425 ,  A61L15/44 ,  A61L2300/106 ,  A61L2300/11 ,  C08L83/04 ,  A61K2300/00

Abstract: Oxygen carrier compounds are impregnated into carrier materials that have free volume, empty or void space or high porosity using sub or supercritical fluid assisted processing. Compositions and methods for the treatment of wounds and burns are provided comprising peroxide compounds or perfluorinated compounds impregnated into carrier materials applied directly to the wound or burn.

Abstract translation: 氧载体化合物被浸渍到具有自由体积，空或空隙空间或使用亚临界或超临界流体辅助处理的高孔隙率的载体材料中。 提供了用于治疗伤口和烧伤的组合物和方法，其包括浸渍到直接施加于伤口或烧伤的载体材料中的过氧化物化合物或全氟化合物。

公开(公告)号：US09765017B2

公开(公告)日：2017-09-19

申请号：US15107962

申请日：2014-12-22

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin K. Safo ,  Richmond Danso-Danquah ,  Mohini Ghatge ,  Jurgen Venitz ,  Martin Mangino ,  Kevin R. Ward

IPC: C07C235/38 ,  A61K31/655 ,  C07C245/24 ,  A61K31/216 ,  A61K31/40 ,  A61K33/00 ,  A61K45/06

CPC classification number: C07C235/38 ,  A61K31/216 ,  A61K31/40 ,  A61K31/655 ,  A61K33/00 ,  A61K45/06 ,  C07C245/24 ,  Y02A50/411 ,  A61K2300/00

Abstract: Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the allosteric hemoglobin modifier to bind Hb and enhance Hb's ability to deliver oxygen to cells and tissues, and also release NO from the NO moiety. Methods of delivering oxygen and/or NO to cells and tissues are also provided.

公开(公告)号：US10969379B2

公开(公告)日：2021-04-06

申请号：US16564917

申请日：2019-09-09

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  Virginia Commonwealth University

Inventor： Rodney C. Daniels ,  Kevin R. Ward ,  Maryanne M. Collinson

IPC: G01N27/327 ,  G01N33/49 ,  B01L3/00 ,  G01N27/30 ,  G01N33/487

Abstract: A bioelectrochemical sensor utilizing a nanoporous gold electrode. The bioelectrochemical sensor is suitable for measuring redox in biologic media while having increased resistance to biofouling as compared to conventional electrodes such as planar gold electrodes, due to greater exposed surface area of the three-dimensional ligature structure defining the nanopores. The nanopores have a pore size of 5-100 nm, preferably with an average pore size of less than 50 nm, and more preferably with an average pore size of less than 20 nm.

公开(公告)号：US10751494B2

公开(公告)日：2020-08-25

申请号：US15274725

申请日：2016-09-23

Applicant: Virginia Commonwealth University

Inventor： Kevin R. Ward ,  Curtis N. Sessler ,  Mary Jo Grap ,  Laurence J. DiNardo ,  Bruce D. Spiess ,  Rao R. Ivatury ,  Cindy Munro

IPC: A61M16/04

Abstract: Ventilator associated pneumonia (VAP) may be prevented in a patient, or its occurrence reduced in a population of patients, by using an anti-VAP device or an anti-VAP material such as an anti-VAP mouthpiece that absorbs secretions. By reducing the problem of bacterial-containing secretions that otherwise build up in the airway of, and elsewhere in, the intubated patient, VAP can be prevented from occurring in intubated patients, such as patients intubated with an endotracheal tube (ETT) or a nasogastric tube. Anti-VAP mouthpieces also are useable in non-intubated patients to maintain oral hygiene.

公开(公告)号：US20200003754A1

公开(公告)日：2020-01-02

申请号：US16564917

申请日：2019-09-09

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  Virginia Commonwealth University

Inventor： Rodney C. Daniels ,  Kevin R. Ward ,  Maryanne M. Collinson

IPC: G01N33/49 ,  B01L3/00 ,  G01N27/30 ,  G01N27/327 ,  G01N33/487

Abstract: A bioelectrochemical sensor utilizing a nanoporous gold electrode. The bioelectrochemical sensor is suitable for measuring redox in biologic media while having increased resistance to biofouling as compared to conventional electrodes such as planar gold electrodes, due to greater exposed surface area of the three-dimensional ligature structure defining the nanopores. The nanopores have a pore size of 5-100 nm, preferably with an average pore size of less than 50 nm, and more preferably with an average pore size of less than 20 nm.

公开(公告)号：US10451606B2

公开(公告)日：2019-10-22

申请号：US15030958

申请日：2014-10-21

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Rodney C. Daniels ,  Kevin R. Ward ,  Maryanne M. Collinson

IPC: G01N27/30 ,  G01N33/49 ,  G01N27/327 ,  B01L3/00 ,  G01N33/487

Abstract: A bioelectrochemical sensor utilizing a nanoporous gold electrode. The bioelectrochemical sensor is suitable for measuring redox in biologic media while having increased resistance to biofouling as compared to conventional electrodes such as planar gold electrodes, due to greater exposed surface area of the three-dimentional ligature structure defining the nanopores. The nanopores have a pore size of 5-100 nm, preferably with an average pore size of less than 50 nm, and more preferably with an average pore size of less than 20 nm.

公开(公告)号：US20130310779A1

公开(公告)日：2013-11-21

申请号：US13952186

申请日：2013-07-26

Applicant: Virginia Commonwealth University

Inventor： Gary Wnek ,  Marcus E. Carr, JR. ,  Gary Bowlin ,  Kelman I. Cohen ,  Kevin R. Ward ,  Wayne Barbee ,  Rao Ivatury

IPC: A61L26/00

CPC classification number: A61L26/0061 ,  A61B17/0057 ,  A61B17/122 ,  A61B17/132 ,  A61B2017/00659 ,  A61F13/0269 ,  A61K9/0048 ,  A61L15/22 ,  A61L24/106 ,  A61L24/108 ,  A61L2400/04

Abstract: High-pressure bleeding wounds (and other bleeding wounds) may be treated by applying direct pressure directly in the bleeding wound, such as by applying a back pressure in a confined space around and in the wound. Certain substances and articles may be inserted into the wound, and the wound may be enclosed with that substance or article (such as a hemostatic substance, which may be polymeric), by swelling on contact with molecules (such as water molecules in the blood) encountered in the wound, generates the desired pressure to stop or at least reduce the bleeding without the detrimental effects of a tourniquet. Clot-inducing substances may be introduced into the wound contemporaneously with direct pressure application directly in the wound. Compressible and non-compressible wounds are treated. Treatment stops bleeding without producing pressure injury or ischemic damage. Medical devices using this technology are provided, including removable, biodegradable, medic-administrable devices.

Abstract translation: 可以通过直接对出血伤口施加直接压力来治疗高压出血性伤口（和其他出血性伤口），例如通过在围绕和缠绕的受限空间中施加背压。 某些物质和制品可以插入到伤口中，并且伤口可以与该物质或制品（例如可以是聚合物的止血物质）一起被封闭，通过与分子（例如血液中的水分子）接触而膨胀， 在伤口中遇到，产生所需的停止压力或至少减少出血，而不会有止血带的不利影响。 可以直接在伤口中直接施加压力诱导物质同时引入伤口。 可压缩和不可压缩的伤口被处理。 治疗停止出血而不产生压力损伤或缺血性损伤。 提供使用此技术的医疗设备，包括可拆卸，可生物降解的医疗管理设备。