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    Process for the preparation of HBN
    4.
    发明授权
    Process for the preparation of HBN 失效
    制备HBN的方法

    公开(公告)号：US5294416A

    公开(公告)日：1994-03-15

    申请号：US943768

    申请日：1992-09-11

    申请人： Abram Becker ,  Hyman Stollar

    发明人： Abram Becker ,  Hyman Stollar

    IPC分类号： C07C253/14 ,  C07C255/53 ,  C01G3/00

    CPC分类号： C07C253/14 ,  C07C255/53

    摘要： In a process for the preparation and the isolation of p-hydroxybenzonitrile (HBN), in which a p-halogenated phenol is reacted with cuprous cyanide in a suitable solvent, the reaction mixture obtained after the reaction of the p-halogenated phenol with cuprous cyanide has been substantially completed is contacted with an aqueous solution of a bromide salt and, optionally, an organic diluent, the aqueous and organic phases are separated, HBN is distilled out from the organic phase, an alkali metal cyanide is added to the aqueous phase and CuCN is filtered off from the resulting aqueous phase.

    摘要翻译： 在制备和分离对羟基苯甲腈（HBN）的方法中，其中对卤代苯酚与氰化亚铜在合适的溶剂中反应，反应混合物在对卤代苯酚与氰化亚铜反应后得到 已经基本完成的是与溴化物盐和任选的有机稀释剂的水溶液接触，分离水相和有机相，将HBN从有机相中蒸出，将碱金属氰化物加入到水相中， 从所得水相中过滤出CuCN。

    Process for the preparation and isolation of HBN
    6.
    发明授权
    Process for the preparation and isolation of HBN 失效
    HBN的制备和分离方法

    公开(公告)号：US5169972A

    公开(公告)日：1992-12-08

    申请号：US621350

    申请日：1990-12-03

    申请人： Abram Becker ,  Hyman Stollar

    发明人： Abram Becker ,  Hyman Stollar

    IPC分类号： C07C253/14 ,  C07C255/53

    CPC分类号： C07C253/14 ,  C07C255/53

    摘要： In a process for the preparation and the isolation of p-hydroxybenzonitrile (HBN), in which a p-halogenated phenol is reacted with cuprous cyanide in a suitable solvent, the reaction mixture obtained after the reaction of the p-halogenated phenol with cuprous cyanide has been substantially completed is contacted with an aqueous solution of a bromide salt and, optionally, an organic diluent, the aqueous and organic phases are separated, HBN is distilled out from the organic phase, an alkali metal cyanide is added to the aqueous phase and CuCN is filtered off from the resulting aqueous phase.

    摘要翻译： 在制备和分离对羟基苯甲腈（HBN）的方法中，其中对卤代苯酚与氰化亚铜在合适的溶剂中反应，反应混合物在对卤代苯酚与氰化亚铜反应后得到 已经基本完成的是与溴化物盐和任选的有机稀释剂的水溶液接触，分离水相和有机相，将HBN从有机相中蒸出，将碱金属氰化物加入到水相中， 从所得水相中过滤出CuCN。

    Process for the preparation of 2,4-diamino-5-benzylpyrimidines
    8.
    发明授权
    Process for the preparation of 2,4-diamino-5-benzylpyrimidines 失效
    2,4-二氨基-5-苄基嘧啶的制备方法

    公开(公告)号：US4789743A

    公开(公告)日：1988-12-06

    申请号：US080083

    申请日：1987-07-31

    申请人： Abram Becker

    发明人： Abram Becker

    IPC分类号： A61K31/505 ,  A61P31/04 ,  C07C255/53 ,  C07D239/48 ,  C07D239/49 ,  C07D239/28

    CPC分类号： C07D239/49 ,  C07C255/00

    摘要： The invention relates to a process for the preparaton of compounds of the formula I by reacting an alkali metal alcoholate with a compound of the formula II in the presence of an aliphatic ester such as methyl formate, and then condensing guanidine with the resulting compound of the formula III.The compound of the formula II can be prepared by reacting the corresponding benzaldehyde with acrylonitrile in the presence of diazabicyclo-2,2,2,-octane. ##STR1##

    摘要翻译： 本发明涉及一种在脂肪族酯如甲酸甲酯存在下使碱金属醇化物与式II化合物反应制备式I化合物的方法，然后将胍与所得化合物 公式三。 式II化合物可以通过在二氮杂双环-2,2,2， - 辛烷存在下使相应的苯甲醛与丙烯腈反应来制备。 III。影像> I II III