-
1.发明授权Tetrahydroquinolones and their use as modulators of metabotropic glutamate receptors 失效四氢喹诺酮类及其作为代谢型谷氨酸受体的调节剂公开(公告)号：US07550482B2
公开(公告)日：2009-06-23
申请号：US11210569
申请日：2005-08-24
申请人： Valerjans Kauss , Ieva Jaunzeme , Aigars Jirgensons , Ivars Kalvinsh , Maksims Vanejevs , Markus Henrich , Wojciech Danysz , Claudia Jatzke , Christopher Graham Raphael Parsons , Tanja Weil
发明人： Valerjans Kauss , Ieva Jaunzeme , Aigars Jirgensons , Ivars Kalvinsh , Maksims Vanejevs , Markus Henrich , Wojciech Danysz , Claudia Jatzke , Christopher Graham Raphael Parsons , Tanja Weil
IPC分类号： C07D215/38 , A61K31/44
CPC分类号： C07D215/20 , C07D215/227 , C07D215/36 , C07D215/38 , C07D215/54 , C07D221/06 , C07D221/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.
摘要翻译： 本发明涉及乙炔基取代的四氢喹啉酮衍生物及其药学上可接受的盐。 本发明还涉及制备这些化合物的方法。 本发明的化合物是I组mGluR调节剂，因此可用于控制和预防急性和/或慢性神经障碍。
-
2.发明授权Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors 失效四氢喹啉酮及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US07598384B2
公开(公告)日：2009-10-06
申请号：US11066899
申请日：2005-02-25
申请人： Aigars Jirgensons , Christopher Graham Raphael Parsons , Ieva Jaunzeme , Ivars Kalvinsh , Markus Henrich , Maksims Vanejevs , Tanja Weil , Valerjans Kauss , Wojciech Danysz
发明人： Aigars Jirgensons , Christopher Graham Raphael Parsons , Ieva Jaunzeme , Ivars Kalvinsh , Markus Henrich , Maksims Vanejevs , Tanja Weil , Valerjans Kauss , Wojciech Danysz
IPC分类号： C07D215/38
CPC分类号： C07D215/54 , C07D215/20 , C07D215/227 , C07D215/36 , C07D215/38 , C07D221/06 , C07D221/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The invention relates to tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR antagonists and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.
摘要翻译： 本发明涉及四氢喹啉酮衍生物及其药学上可接受的盐。 本发明还涉及制备这些化合物的方法。 本发明的化合物是I组mGluR拮抗剂，因此可用于控制和预防急性和/或慢性神经障碍。
-
3.发明申请Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors 审中-公开四氢喹啉酮及其作为代谢型谷氨酸受体的调节剂的用途公开(公告)号：US20090227582A1
公开(公告)日：2009-09-10
申请号：US12387863
申请日：2009-05-08
申请人： Valerjans Kauss , Ieva Jaunzeme , Aigars Jirgensons , Ivars Kalvinsh , Maksims Vanejevs , Markus Henrich , Wojciech Danysz , Claudia Jatzke , Christopher G.R. Parsons , Tanja Weil
发明人： Valerjans Kauss , Ieva Jaunzeme , Aigars Jirgensons , Ivars Kalvinsh , Maksims Vanejevs , Markus Henrich , Wojciech Danysz , Claudia Jatzke , Christopher G.R. Parsons , Tanja Weil
IPC分类号： A61K31/4709 , A61K31/47 , A61K31/5377 , A61P25/28
CPC分类号： C07D215/20 , C07D215/227 , C07D215/36 , C07D215/38 , C07D215/54 , C07D221/06 , C07D221/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.
摘要翻译： 本发明涉及乙炔基取代的四氢喹啉酮衍生物及其药学上可接受的盐。 本发明还涉及制备这些化合物的方法。 本发明的化合物是I组mGluR调节剂，因此可用于控制和预防急性和/或慢性神经障碍。
-
4.发明申请Tetrahydroquinolones and their use as modulators of metabotropic glutamate receptors 失效四氢喹诺酮类及其作为代谢型谷氨酸受体的调节剂公开(公告)号：US20050288284A1
公开(公告)日：2005-12-29
申请号：US11210569
申请日：2005-08-24
申请人： Aigars Jirgensons , Christopher Parsons , Ieva Jaunzeme , Ivars Kalvinsh , Markus Henrich , Maksims Vanejevs , Tanja Weil , Valerjans Kauss , Wojciech Danysz
发明人： Aigars Jirgensons , Christopher Parsons , Ieva Jaunzeme , Ivars Kalvinsh , Markus Henrich , Maksims Vanejevs , Tanja Weil , Valerjans Kauss , Wojciech Danysz
IPC分类号： A61K31/4709 , A61K31/506 , A61K31/5377 , C07D215/16 , C07D413/02 , C07D43/02
CPC分类号： C07D215/20 , C07D215/227 , C07D215/36 , C07D215/38 , C07D215/54 , C07D221/06 , C07D221/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.
摘要翻译： 本发明涉及乙炔基取代的四氢喹啉酮衍生物及其药学上可接受的盐。 本发明还涉及制备这些化合物的方法。 本发明的化合物是I组mGluR调节剂，因此可用于控制和预防急性和/或慢性神经障碍。
-
5.发明申请Tetrahydroquinolones and their use as modulators of metabotropic glutamate receptors 审中-公开四氢喹诺酮类及其作为代谢型谷氨酸受体的调节剂公开(公告)号：US20060004001A1
公开(公告)日：2006-01-05
申请号：US11211829
申请日：2005-08-25
申请人： Aigars Jirgensons , Christopher Parsons , Ieva Jaunzeme , Ivars Kalvinsh , Markus Henrich , Maksims Vanejevs , Tanja Weil , Valerjans Kauss , Wojciech Danysz
发明人： Aigars Jirgensons , Christopher Parsons , Ieva Jaunzeme , Ivars Kalvinsh , Markus Henrich , Maksims Vanejevs , Tanja Weil , Valerjans Kauss , Wojciech Danysz
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4709 , C07D413/04 , C07D43/04 , C07D41/04
CPC分类号： C07D215/20 , A61K31/47 , A61K31/4709 , A61K31/506 , A61K31/5377 , C07D215/227 , C07D215/36 , C07D215/38 , C07D215/54 , C07D221/06 , C07D221/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The invention relates to tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.
摘要翻译： 本发明涉及四氢喹啉酮衍生物及其药学上可接受的盐。 本发明还涉及制备这些化合物的方法。 本发明的化合物是I组mGluR调节剂，因此可用于控制和预防急性和/或慢性神经障碍。
-
6.发明申请Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors 失效四氢喹啉酮及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20050197361A1
公开(公告)日：2005-09-08
申请号：US11066899
申请日：2005-02-25
申请人： Aigars Jirgensons , Christopher Parsons , Ieva Jaunzeme , Ivars Kalvinsh , Markus Henrich , Maksims Vanejevs , Tanja Weil , Valerjans Kauss , Wojciech Danysz
发明人： Aigars Jirgensons , Christopher Parsons , Ieva Jaunzeme , Ivars Kalvinsh , Markus Henrich , Maksims Vanejevs , Tanja Weil , Valerjans Kauss , Wojciech Danysz
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/506 , A61K31/5377 , C07D215/16 , C07D215/20 , C07D215/22 , C07D215/227 , C07D215/36 , C07D215/38 , C07D215/54 , C07D221/06 , C07D221/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/02 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14 , C07D43/02
CPC分类号： C07D215/54 , C07D215/20 , C07D215/227 , C07D215/36 , C07D215/38 , C07D221/06 , C07D221/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The invention relates to tetrahydroquinolinone derivatives as well as their pharmaceutially acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR antagonists and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.
摘要翻译： 本发明涉及四氢喹啉酮衍生物及其药学上可接受的盐。 本发明还涉及制备这些化合物的方法。 本发明的化合物是I组mGluR拮抗剂，因此可用于控制和预防急性和/或慢性神经障碍。
-
7.发明授权Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists 失效氨基环己烷NMDA，5HT3和神经元烟碱受体拮抗剂的Azabicyclic，azatricyclic和azaspirocyclic衍生物公开(公告)号：US07022729B2
公开(公告)日：2006-04-04
申请号：US10394670
申请日：2003-03-21
申请人： Christopher Graham Raphael Parsons , Markus Henrich , Wojciech Danysz , Ivars Kalvinsh , Valerjans Kauss , Aigars Jirgensons , Markus Gold , Maksims Vanejevs
发明人： Christopher Graham Raphael Parsons , Markus Henrich , Wojciech Danysz , Ivars Kalvinsh , Valerjans Kauss , Aigars Jirgensons , Markus Gold , Maksims Vanejevs
IPC分类号： A61K31/40 , C07D209/02
CPC分类号： C07D221/20 , A61K31/44 , C07D209/54 , C07D221/22 , C07D471/08 , C07D487/08 , Y02A50/411
摘要： Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.
摘要翻译： 作为NMDA，5HT 3和烟碱型受体拮抗剂具有全身活性的氨基环己烷的氮杂环，氮杂环和azaspirocyclic衍生物，包含它们的药物组合物，其制备方法和治疗CNS疾病的方法，涉及 治疗谷氨酸能，血清素能和烟碱传播的紊乱，治疗免疫调节障碍和抗疟疾，抗睾丸激素，抗牛痘病毒，抗HSV和抗丙型肝炎病毒活性。
-
8.发明申请Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3 and neuronal nicotinic receptor antagonists 失效氨基环己烷NMDA，5HT3和神经元烟碱受体拮抗剂的Azabicyclic，azatricyclic和azaspirocyclic衍生物公开(公告)号：US20060019982A1
公开(公告)日：2006-01-26
申请号：US11202012
申请日：2005-08-11
申请人： Christopher Parsons , Markus Henrich , Wojciech Danysz , Ivars Kalvinsh , Valerjans Kauss , Aigars Jirgensons , Markus Gold , Maksims Vanejevs
发明人： Christopher Parsons , Markus Henrich , Wojciech Danysz , Ivars Kalvinsh , Valerjans Kauss , Aigars Jirgensons , Markus Gold , Maksims Vanejevs
IPC分类号： A61K31/46 , A61K31/407
CPC分类号： C07D221/20 , A61K31/44 , C07D209/54 , C07D221/22 , C07D471/08 , C07D487/08 , Y02A50/411
摘要： Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.
摘要翻译： 作为NMDA，5HT 3和烟碱型受体拮抗剂具有全身活性的氨基环己烷的氮杂环，氮杂环和azaspirocyclic衍生物，包含它们的药物组合物，其制备方法和治疗CNS疾病的方法，涉及 治疗谷氨酸能，血清素能和烟碱传播的紊乱，治疗免疫调节障碍和抗疟疾，抗睾丸激素，抗牛痘病毒，抗HSV和抗丙型肝炎病毒活性。
-
9.发明申请Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3 and neuronal nicotinic receptor antagonists 审中-公开氨基环己烷NMDA，5HT3和神经元烟碱受体拮抗剂的Azabicyclic，azatricyclic和azaspirocyclic衍生物公开(公告)号：US20070185151A1
公开(公告)日：2007-08-09
申请号：US11732764
申请日：2007-04-04
申请人： Christopher Parsons , Markus Henrich , Wojciech Danysz , Ivars Kalvinsh , Valerjans Kauss , Aigars Jirgensons , Markus Gold , Maksims Vanejevs
发明人： Christopher Parsons , Markus Henrich , Wojciech Danysz , Ivars Kalvinsh , Valerjans Kauss , Aigars Jirgensons , Markus Gold , Maksims Vanejevs
IPC分类号： A61K31/44
CPC分类号： C07D221/20 , A61K31/44 , C07D209/54 , C07D221/22 , C07D471/08 , C07D487/08 , Y02A50/411
摘要： Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compostions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.
摘要翻译： 作为NMDA，5HT 3和烟碱型受体拮抗剂具有全身活性的氨基环己烷的氮杂双环，氮杂环和azaspirocyclic衍生物，包含其的药物组合物，其制备方法和治疗CNS病症的方法，涉及 治疗谷氨酸能，血清素能和烟碱传播的紊乱，治疗免疫调节障碍和抗疟疾，抗睾丸激素，抗牛痘病毒，抗HSV和抗丙型肝炎病毒活性。
-
10.发明申请公开(公告)号：US20060019983A1
公开(公告)日：2006-01-26
申请号：US11202115
申请日：2005-08-11
申请人： Christopher Parsons , Markus Henrich , Wojciech Danysz , Ivars Kalvinsh , Valerjans Kauss , Aigars Jirgensons , Markus Gold , Maksims Vanejevs
发明人： Christopher Parsons , Markus Henrich , Wojciech Danysz , Ivars Kalvinsh , Valerjans Kauss , Aigars Jirgensons , Markus Gold , Maksims Vanejevs
IPC分类号： A61K31/46 , A61K31/403
CPC分类号： C07D221/20 , A61K31/44 , C07D209/54 , C07D221/22 , C07D471/08 , C07D487/08 , Y02A50/411
摘要： Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.037 秒)
